Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, ...autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the
gene. In human medicine, isotretinoin is frequently used to treat ARCIs. The aim of this study was to investigate the clinical and histological effects of isotretinoin on ARCI in a golden retriever dog with confirmed mutation in the
gene. Clinical examination, blood analysis and histopathological examinations were conducted before and after 90 days of isotretinoin therapy. The clinical and histopathological findings indicate that treatment with oral isotretinoin was effective in improving ichthyosis without any side-effects.
ATTITUDES TOWARD PEOPLE WITH MENTAL HEALTH DIFFICULTIES The implementation of modern approaches that seek to deinstitutionalize traditional psychiatric services is hampered by unfavorable attitudes ...of the community towards people with mental disabilities. Stigma is one of the most important factors that delay seeking help and negatively affects the quality of life of people with mental health problems. The research was conducted to describe attitudes towards people with mental health problems and determine their relationship with socio-demographic variables, information, and personal experience with mental health problems. There were 108 participants aged 21 to 59 (71% female, 64.5% college and university degrees). The Community Attitudes toward Mental Illness scale (CAMI) (Taylor & Dear, 1981) and a survey questionnaire were used online. Participants have generally benevolent attitudes toward all dimensions of the scale. Higher self-assessment of knowledge about mental health problems leads to more favorable attitudes towards authoritarianism, and younger age to less social restraint. Participants with a high school diploma have more negative attitudes towards the dimensions of authoritarianism and benevolence than participants with a university degree. There are no significant differences in attitudes regarding the experience of seeking mental health support, but on the authoritarian dimension, there is a significant interaction effect of being informed and mental health support seeking. The results indicate the importance of further research into the relationship between attitudes and mental health support seeking and the level of being informed on mental health issues. Key words: mental health; mental health difficulties; attitudes; stigmatization
Implementacija suvremenih pristupa koji teže deinstitucionalizaciji tradicionalnih psihijatrijskih usluga otežana je nepovoljnim stavovima zajednice prema osobama s mentalnim poteškoćama. Stigma je ...jedan od najvažnijih čimbenika koji odgađaju traženje pomoći te negativno utječu na kvalitetu života osoba s poteškoćama mentalnog zdravlja. Provedeno je istraživanje s ciljem opisivanja stavova prema osobama s poteškoćama mentalnog zdravlja te utvrđivanjem njihova odnosa sa sociodemografskim varijablama, informiranošću te osobnim iskustvom s poteškoćama mentalnog zdravlja. Sudjelovalo je 108 sudionika u dobi od 21 do 59 godina (71% ženskih, 64,5% više i visoke stručne spreme). U online obliku primijenjena je Skala stavova zajednice prema osobama s poteškoćama mentalnog zdravlja (CAMI) (Taylor i Dear, 1981.) te anketni upitnik sastavljen za potrebe istraživanja. Sudionici imaju uglavnom blagonaklone stavove na svim dimenzijama skale. Viša samoprocjena informiranosti vodi povoljnijim stavovima na autoritarnosti, a mlađa dob manjem socijalnom ograničavanju. Sudionici sa SSS-om imaju negativnije stavove na dimenzijama autoritarnosti i benevolentnosti od sudionika s VSS-om. Nema značajnih razlika u stavovima s obzirom na iskustvo s traženjem podrške za mentalno zdravlje, no na dimenziji autoritarnosti značajan je interakcijski efekt informiranosti i traženja podrške. Rezultati ukazuju na važnost daljnjeg istraživanja odnosa stavova s traženjem podrške za mentalno zdravlje te razinom informiranosti o pitanjima zaštite mentalnog zdravlja.
Alcohol consumption in adolescents is a risk factor for several short- and long-term consequences. The impact of the family on starting with alcohol consumption and on frequent and excessive drinking ...is indisputable, which is explained through a series of risk and protective factors of the family environment. Awareness of these factors helps in designing effective prevention programs for reducing the prevalence of alcohol consumption among children and young people. During the school year 2019/20, a study was conducted on a stratified sample. The study included 1409 students (48.3% boys and 51.7% girls) aged 13 to 19 (M=15.84, sd=1.46) from 16 primary (eighth grade) and 20 secondary schools (all four grades) from the Split-Dalmatia County. The aim was to determine the relationship between adolescents’ alcohol consumption and their perception of parental monitoring, expected parental reactions to intoxication, and satisfaction with relations with parents, but also to provide an insight into current alcohol consumption habits among adolescents in the Split-Dalmatia County. The results show differences in alcohol consumption habits with respect to gender and school grade. Compared to students who drink less, the perception of students who are more prone to alcohol consumption is that their parents are both less likely to have rules of conduct outside home, and are often unaware of where and who their children socialize with. In addition, their expected parental reactions to drinking are milder. A correlation between alcohol consumption and satisfaction with parent-child relations was not established. Gender, age, school, perceived monitoring, and perceived parental reactions predict 33.7% of variability of alcohol consumption ever in life and 22.3% variability of alcohol consumption in previous month. Age, gender, perceived monitoring, perceived parental reactions to intoxication and frequency alcohol consumption in previous month together predict 40.3% of variability of frequency of intoxication ever in life, and 24.3% variability of frequency of intoxication in previous month.
Konzumacija alkohola adolescenata rizična je zbog niza kratkoročnih i dugoročnih posljedica. Neprijeporan je utjecaj obitelji na početak konzumacije te na učestalo i prekomjerno pijenje, što je ...objašnjeno nizom rizičnih i zaštitnih čimbenika obiteljskog okruženja. Njihovo poznavanje i prepoznavanje pomaže u osmišljavanju učinkovitih preventivnih programa radi smanjivanja prevalencije konzumacije alkohola djece i mladih. U školskoj godini 2019./2020. provedeno je istraživanje na stratificiranom uzorku. Sudjelovalo je 1409 učenika (48,3% mladića i 51,7% djevojaka) u dobi od 13 do 19 godina (M = 15,84; sd = 1,46) iz 16 osnovnih (osmi razred) i 20 srednjih škola (sva četiri razreda) s područja Splitsko-dalmatinske županije. Cilj je rada utvrditi odnos konzumacije alkohola među adolescentima s njihovom percepcijom roditeljskog nadzora, očekivanih roditeljskih reakcija na opijanje te zadovoljstvom odnosa s roditeljima, ali i ponuditi uvid u trenutačne navike konzumacije alkohola među adolescentima Splitsko-dalmatinske županije. Utvrđene su razlike u navikama konzumacije alkohola s obzirom na rod i razred. U usporedbi s učenicima koji manje piju, učenici skloniji konzumaciji alkohola rjeđe smatraju da postoje pravila ponašanja izvan kuće, da njihovi roditelji znaju gdje su i s kim se druže te misle da bi reakcije njihovih roditelja na opijanje bile blaže. Konzumacija alkohola nije se pokazala povezanom sa zadovoljstvom odnosa s roditeljima. Rod, dob, percepcija nadzora i očekivane roditeljske reakcije na opijanje predviđaju 33,7% varijabiliteta konzumacije alkohola u životu i 22,3% varijabiliteta konzumacije u posljednjih mjesec dana. Dob, rod, percepcija roditeljskog nadzora, očekivane reakcije roditelja na opijanje i učestalost konzumacije alkohola u posljednjih mjesec dana predviđaju zajedno 40,3% varijabiliteta učestalosti opijanja u životu i 24,3% varijabiliteta učestalosti opijanja u posljednjih mjesec dana.
Alcohol consumption in adolescents is a risk factor for several short- and long-term consequences. The impact of the family on starting with alcohol consumption and on frequent and excessive drinking is indisputable, which is explained through a series of risk and protective factors of the family environment. Awareness of these factors helps in designing effective prevention programs for reducing the prevalence of alcohol consumption among children and young people. During the school year 2019/20, a study was conducted on a stratified sample. The study included 1409 students (48.3% boys and 51.7% girls) aged 13 to 19 (M=15.84, sd=1.46) from 16 primary (eighth grade) and 20 secondary schools (all four grades) from the Split-Dalmatia County. The aim was to determine the relationship between adolescents’ alcohol consumption and their perception of parental monitoring, expected parental reactions to intoxication, and satisfaction with relations with parents, but also to provide an insight into current alcohol consumption habits among adolescents in the Split-Dalmatia County. The results show differences in alcohol consumption habits with respect to gender and school grade. Compared to students who drink less, the perception of students who are more prone to alcohol consumption is that their parents are both less likely to have rules of conduct outside home, and are often unaware of where and who their children socialize with. In addition, their expected parental reactions to drinking are milder. A correlation between alcohol consumption and satisfaction with parent-child relations was not established. Gender, age, school, perceived monitoring, and perceived parental reactions predict 33.7% of variability of alcohol consumption ever in life and 22.3% variability of alcohol consumption in previous month. Age, gender, perceived monitoring, perceived parental reactions to intoxication and frequency alcohol consumption in previous month together predict 40.3% of variability of frequency of intoxication ever in life, and 24.3% variability of frequency of intoxication in previous month.
Background
Cutaneous bullous mastocytosis (CBM) is a rare disease characterised by erythroderma, bullae formation on trunk, scalp and extremities which evolve to erosions.
Objective
To describe a ...rare variant of cutaneous mastocytosis and treatment options.
Animal
A 7‐month‐old Yorkshire terrier puppy with erythroderma and bullae formation.
Methods
Clinical examination (including haematological, biochemical and radiographic), skin biopsy, histopathological and immunohistochemical evaluation.
Conclusion and clinical relevance
The case fulfills the criteria of CBM, representing a rare entity that is reported to be associated with spontaneous regression. However, in severe cases treatment with systemic corticosteroids, H1 and H2 antihistamines, and masitinib can be performed.
Résumé
Contexte – La mastocytose cutanée bulleuse (CBM) est une maladie rare caractérisée par une érythrodermie, la formation de bulles sur le tronc, le cuir chevelu et les extrémités qui évoluent vers des érosions.
Objectif – Décrire une variante rare de la mastocytose cutanée et les options de traitement.
Animal ‐ Un chiot Yorkshire terrier de 7 mois avec formation d'érythrodermie et de bulles.
Méthodes – Examen clinique (y compris hématologique, biochimique et radiographique), biopsie cutanée, évaluation histopathologique et immunohistochimique.
Conclusion et pertinence clinique – Le cas remplit les critères de CBM, représentant une entité rare rapportée comme étant associée à une régression spontanée. Cependant, dans les cas graves, un traitement avec des corticostéroïdes systémiques, des antihistaminiques H1 et H2 et du masitinib peut être effectué.
Resumen
Introducción – la mastocitosis bullosa cutánea (CBM) es una enfermedad rara caracterizada por eritroderma, formación de bullas en el tronco, cabeza y extremidades que evolucionan a erosiones.
Objetivo – describir una variante rara de mastocitosis cutánea y opciones de tratamiento.
Animal‐ un cachorro Yorkshire terrier de 7 meses con eritroderma y formación de bullas.
Métodos – examen clínico (incluyendo hematológico, bioquímico y radiográfico), biopsia de piel, evaluación histopatológica e inmunohistoquímica.
Conclusión y relevancia clínica‐ el caso descrito cumple con los criterios de CBM, lo que representa una entidad rara que se describe como asociada con regresión espontánea. Sin embargo, en casos graves se puede realizar tratamiento con corticoides sistémicos, antihistamínicos H1 y H2 y masitinib.
Zusammenfassung
Hintergrund – Die kutane bullöse Mastozytose (CBM) ist eine seltene Erkrankung, die durch Erythrodermie, Blasenbildung am Rumpf, auf der Kopfhaut und den Extremitäten, welche sich zu Erosionen entwickeln, charakterisiert wird.
Ziel – Die Beschreibung einer seltenen Variante einer kutanen Mastozytose und ihrer Behandlungsoptionen.
Tier – Ein 7 Monate alter Yorkshire Terrier mit Erythrodermie und Blasenbildung.
Methoden – Klinische Untersuchung (inklusive Hämatologie, Biochemie und Röntgenuntersuchung), Hautbiopsie, histopathologische und immunhistochemische Evaluierung.
Schlussfolgerung und klinische Bedeutung – Dieser Fall erfüllt die Kriterien einer CBM, wodurch er eine seltene Einheit repräsentiert, welche im Zusammenhang mit einer spontanen Regression beschrieben wird. In schwerwiegenden Fällen kann jedoch eine Behandlung mit systemischen Glukokortikoiden, H1 und H2 Antihistaminen, und mit Masitinib erfolgen.
要約
背景 ‐ 皮膚水疱性肥満細胞症 (CBM) は、紅皮症、体幹・頭皮・四肢の水疱形成、びらんへと進展することを特徴とする希少疾患である。
目的 – 本研究の目的は、皮膚肥満細胞症のまれな変異型と治療法について説明することであった。
供試動物 ‐ 紅皮症および水疱形成を呈した7ヶ月齢のヨークシャーテリア子犬。
方法 ‐ 臨床検査 (血液学的、生化学的、X線検査を含む) 、皮膚生検、病理組織学的、免疫組織化学的評価。
結論および臨床的意義 ‐ 本症例は、自然退縮を伴うと報告されている稀な疾患であるCBM の基準を満たしている。しかし、重症例では、全身性コルチコステロイド、H1およびH2抗ヒスタミン薬、マシチニブによる治療が行われることがある。
摘要
背景‐皮肤大疱性肥大细胞增多症(CBM)是一种罕见疾病, 其特征为皮肤发红,躯干、头皮和四肢大疱形成, 并进展为糜烂。
目的‐描述一种罕见的皮肤肥大细胞增多症变体和治疗方案。
动物‐7月龄约克夏幼犬, 有皮肤发红和大疱形成。
方法‐临床检查 (包括血液学、生化和影像学) 、皮肤活检、组织病理学和免疫组织化学评价。
结论和临床相关性‐该病例符合CBM标准, 代表了报告与自发消退相关的罕见疾病。然而, 在重度病例中, 可进行全身皮质类固醇、H1和H2抗组胺药和马赛替尼治疗。
Resumo
Contexto – A mastocitose cutânea bolhosa (MCB) é uma doença rara caracterizada por eritrodermia, formações bolhosas no tronco, cabeça e extremidades que evoluem para erosões.
Objetivo – Descrever uma variante rara de mastocitose cutânea e as opções de tratamento.
Animal – Um filhote de Yorkshire terrier de sete meses de idade com eritrodermia e formações bolhosas.
Métodos – Exame clínico (incluindo avaliação hematológica, bioquímica e radiográfica), biópsia de pele, histopatologia e avaliação imunohistoquímica.
Conclusão e relevância clínica – Esse caso preenche os critérios de MCB, representando uma entidade rara em que a regressão espontânea é relatada. Entretanto, em casos graves, tratamento com corticosteroides, anti‐histamínicos H1 e H2 e masitinib podem ser realizados.
Background – Cutaneous bullous mastocytosis (CBM) is a rare disease characterised by erythroderma, bullae formation on trunk, scalp and extremities which evolve to erosions. Objective – To describe a rare variant of cutaneous mastocytosis and treatment options. Conclusion and clinical relevance – The case fulfills the criteria of CBM, representing a rare entity that is reported to be associated with spontaneous regression. However, in severe cases treatment with systemic corticosteroids, H1 and H2 antihistamines, and masitinib can be performed.
Background
Symmetrical alopecia is a common symptom of endocrine and autoimmune diseases, which are rarely manifested with pruritus. Increased levels of stress in primates have been presented with ...increased levels of pruritus and alopecia appearance.
Methods
A pruritic and alopecic disease was investigated in a group of tufted capuchin monkeys (N = 12), but due to ethical reasons, four random animals were further investigated by numerous diagnostic methods. The impact of food and enclosure enrichment was assessed and observed over a 2‐year period.
Results
Histopathology of four random tufted capuchin monkeys revealed lymphocytic perifolliculitis, with an appearance of a “swarm of bees” which was suggestive of alopecia areata. Etiological classification of pruritus excluded dermatological, systemic, and neurological causes, making it behavioral. Enclosure and food enrichment had a beneficial impact on pruritus (12/12) and alopecia (10/12).
Conclusion
The findings were suggestive of alopecia areata, while the pruritus was considered behavioral in origin. Alopecia and pruritus improved upon enclosure and food enrichment.
AbstractThe present study investigates the somatization symptoms among grammar school students. High school students (N=218) from a convenience sample school were asked to complete The Somatization ...Scale. Data analysis showed that girls reported somatization symptoms more frequently than boys. The analysis showed that 1.4% of students felt some of the somatic symptoms on a daily basis, while 6.9% of students had such symptoms 2-3 times a week. Other students reported physical symptoms less frequently. 41.3% of students reported having somatic symptoms once a week and 46.8% of the students complained of somatic symptoms once or twice a month. Only 3.2% of students said that they had never experienced such symptoms. The most common somatic symptoms in adolescence are headaches and fatigue, while the rarest physical symptom is abdominal pain. Contemporary authors associated somatization tendencies with stressful situations in school. Therefore, it is important that parents, teachers and school counselors are familiar with the frequency and potential causes of somatic symptoms in adolescence. Key words: high school; physical symptoms; stress. ---SažetakIstraživanje je provedeno s ciljem utvrđivanja učestalosti simptoma somatizacije kod učenika gimnazije. Učenici gimnazije (N=218) iz prigodno odabrane škole su tijekom nastave ispunjavali Skalu somatizacije. Obradom podataka utvrđeno je kako djevojke češće od mladića izvještavaju o somatizacijskim tegobama. Pokazalo se kako 1.4% učenika osjeća neku od somatskih tegoba svakodnevno, a kod 6.9% učenika su takve tegobe prisutne 2-3 puta tjedno. U ostalih se učenika tjelesne tegobe javljaju rjeđe, pa 41.3% učenika ima somatizacijske smetnje jednom tjedno, 46.8% ih primjećuje jednom do dva puta mjesečno. Samo 3.2% učenika tvrdi da ih ne osjeća nikada. Kao najučestalije somatske smetnje istaknute su glavobolja i osjećaj umora, a abdominalni bolovi najrjeđe su prisutna tjelesna tegoba u adolescenata. Budući da suvremeni autori povezuju sklonost somatizaciji s izloženošću stresnim situacijama u školi, važno je da roditelji, učitelji i stručni suradnici budu upoznati s učestalošću i potencijalnim uzrocima somatskih tegoba kod adolescenata. Ključne riječi: tjelesni simptomi; srednja škola; stres.
BACKGROUNDCutaneous bullous mastocytosis (CBM) is a rare disease characterised by erythroderma, bullae formation on trunk, scalp and extremities which evolve to erosions. OBJECTIVETo describe a rare ...variant of cutaneous mastocytosis and treatment options. ANIMALA 7-month-old Yorkshire terrier puppy with erythroderma and bullae formation. METHODSClinical examination (including haematological, biochemical and radiographic), skin biopsy, histopathological and immunohistochemical evaluation. CONCLUSION AND CLINICAL RELEVANCEThe case fulfills the criteria of CBM, representing a rare entity that is reported to be associated with spontaneous regression. However, in severe cases treatment with systemic corticosteroids, H1 and H2 antihistamines, and masitinib can be performed.
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