Background
Membranous aplasia cutis congenita (MACC) presents at birth characterized by oval epidermis defect. Skin lesions with MACC have various clinic manifestations. In recent years, the ...usefulness of trichoscopy (scalp dermoscopy) has been reported for hair loss diseases. However, the dermoscopic features of MACC were mostly reported by case reports.
Objectives
To summarized the obvious dermoscopic characteristics of MACC.
Materials & Methods
These 56 cases met the clinical diagnostic criteria for MACC without forceps delivery complications or other birth injuries. To find the dermoscopic characteristics of MACC by summarizing 56 infants' dermoscopic pictures.
Results
The dermoscopic manifestation of MACC are characterized by hair follicle openings and hair deficiency in the center of skin lesions, translucent epidermis, hair root and hair bulb arranged along the margins of skin lesion.
Conclusion
The typical dermoscopic characteristics of MACC could help clinicians to early diagnose and differential diagnosis.
A novel one-pot synthetic method of 4-methylimidazol-2-one is described. The target compound is conveniently synthesized from sodium diformylamide, a modified Gabriel reagent prepared, through ...condensation, hydrolyzation and cyclization reactions without separating intermediates, its total yield is 75.8%.
A new photochromic diarylethene compound, 1-2-methyl-(5-(4- dioxolane) phenyl)-3-thienyl-2-(2-methyl-3-benzothiophene)perfluorocyclopentene (1o)was synthesized. Its properties, including ...photochromism and fluorescence were investigated in detail both in solution and PMMA amorphous film. It underwent reversible cyclization and cycloreversion reactions upon alternating irradiation with UV and visible light in hexane. The compound showed good phtochromism both in solution and in solid states. Diarylethene 1o changed the color from colorless to purple upon irradiation with 297 nm UV light, in which absorption maxima were observed at 539 nm in hexane and at 547nm in PMMA film, respectively. Using diarylethene 1c/PMMA film as recording medium, optical recording was performed successfully. This new photochromic system also exhibited remarkable optical storage character
Applying mathematic models to evaluate absorbed-N effects on dry matter production at different developmental stages would help determine proper nitrogen management according to crop demands and ...yield target. Two field trials were carried out for establishing absorbed-N effects on dry matter production（ANEDr） model, using uniform design in 2010–2011and 2012–2013 winter wheat growing seasons in Hebei Province, China. Another field trial was carried out in 2010–2011for model validation. Dry matter and N concentration in leaf and non-leaf organs were measured at setting, jointing, anthesis, and maturity. Theory of best linear unbiased prediction（BLUP） was applied to analyse the N effects of leaf and non-leaf organs on dry matter production. Within ANEDr model, four N-affected phases at each stage were concerned,leaf absorbed-N effect before this stage, non-leaf organ absorbed-N effect before this stage,leaf absorbed-N effect at this stage, and non-leaf organ absorbed-N effect at this stage. In addition, developmental processes, genotype characters and temperature were three factors that determine each N effect. It was demonstrated that ANEDr model can precisely quantify absorbed-N effects on dry matter production with high correlation coefficient（r=0.95）. Comparing with other models, ANEDr model considered both leaf and non-leaf organs according to developmental processes of winter wheat, showed higher flexibility and simplicity, thus could be applied to different environments, cultivars and crops after parameter adjustment.
Applying mathematic models to evaluate absorbed-N effects on dry matter production at different developmental stages would help determine proper nitrogen management according to crop demands and ...yield target. Two field trials were carried out for establishing absorbed-N effects on dry matter production(ANEDr) model, using uniform design in 2010–2011and 2012–2013 winter wheat growing seasons in Hebei Province, China. Another field trial was carried out in 2010–2011for model validation. Dry matter and N concentration in leaf and non-leaf organs were measured at setting, jointing, anthesis, and maturity. Theory of best linear unbiased prediction(BLUP) was applied to analyse the N effects of leaf and non-leaf organs on dry matter production. Within ANEDr model, four N-affected phases at each stage were concerned,leaf absorbed-N effect before this stage, non-leaf organ absorbed-N effect before this stage,leaf absorbed-N effect at this stage, and non-leaf organ absorbed-N effect at this stage. In addition, developmental processes, genotype characters and temperature were three factors that determine each N effect. It was demonstrated that ANEDr model can precisely quantify absorbed-N effects on dry matter production with high correlation coefficient(r=0.95). Comparing with other models, ANEDr model considered both leaf and non-leaf organs according to developmental processes of winter wheat, showed higher flexibility and simplicity, thus could be applied to different environments, cultivars and crops after parameter adjustment.
Myocardial tissue-level perfusion failure is associated with adverse outcomes following ST-elevation myocardial infarction (STEMI) despite successful epicardial recanalization. We have developed a ...new quantitative index-thrombolysis in myocardial infarction (TIMI) myocardial perfusion frame count (TMPFC)--for assessing myocardial tissue level perfusion. However, factors affecting this novel index of myocardial perfusion are currently unknown.
A total of 255 consecutive STEMI patients undergoing primary angioplasty were enrolled. Myocardial tissue level perfusion was assessed by TMPFC, which measures the filling and clearance of contrast in the myocardium using cine-angiographic frame counting. We differentiate three groups with two cut off values for TMPFC: a TMPFC of 90 frames was the upper boundary of the 95% confidence interval (CI) for the TMPFC observed in normal arteries, and a TMPFC of 130 was the 75th percentile of TMPFC.
STEMI patients with TMPFC > 130 frames (68 patients, 26.7%) had higher clinical and angiographic risk factor profiles as well as a higher 30-day MACE rate compared with those with TMPFC ≤ 90 frames and those with TMPFC > 90 and ≤ 130 frames. Multivariable analysis identified that the independent predictors of TMPFC > 130 frames were age ≥ 75 years (OR 2.08, 95%CI 1.21 to 3.58, P = 0.007), diabetes (OR 1.37, 95%CI 1.01 to 1.86, P = 0.042), Killip class ≥ 2 (OR 1.52, 95%CI 1.05 to 2.21, P = 0.027), and prolonged pain-to-balloon time (OR 1.73, 95%CI 1.07 to 2.79, P = 0.013). TMPFC > 130 frames was identified as the strongest independent predictor of 30-day major adverse cardiac event (MACE) (OR 2.77, 95%CI 1.21 to 6.31, P = 0.008), along with age ≥ 75 years (OR 2.19, 95%CI 1.11 to 4.33, P = 0.016), female gender (OR 1.67, 95%CI 1.03 to 2.70, P = 0.038), and Killip class ≥ 2 (OR 1.83, 95%CI 1.07 to 3.14, P = 0.021).
STEMI patients with poor myocardial perfusion assessed by TMPFC had higher risk factor profiles. Advanced age, diabetes, higher Killip class, and longer ischemia time were independent predictors of impaired TMPFC after primary percutaneous coronary intervention. These results emphasize that particular attention should be paid on myocardial microvascular reperfusion in STEMI patients with these risk factors.
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