Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual brain size can vary almost twofold among ...typically developing humans, but the consequences of this for brain organization remain poorly understood. Using in vivo neuroimaging data from more than 3000 individuals, we find that larger human brains show greater areal expansion in distributed frontoparietal cortical networks and related subcortical regions than in limbic, sensory, and motor systems. This areal redistribution recapitulates cortical remodeling across evolution, manifests by early childhood in humans, and is linked to multiple markers of heightened metabolic cost and neuronal connectivity. Thus, human brain shape is systematically coupled to naturally occurring variations in brain size through a scaling map that integrates spatiotemporally diverse aspects of neurobiology.
The cerebellum is a large hindbrain structure that is increasingly recognized for its contribution to diverse domains of cognitive and affective processing in human health and disease. Although ...several of these domains are sex biased, our fundamental understanding of cerebellar sex differences-including their spatial distribution, potential biological determinants, and independence from brain volume variation-lags far behind that for the cerebrum. Here, we harness automated neuroimaging methods for cerebellar morphometrics in 417 individuals to (1) localize normative male-female differences in raw cerebellar volume, (2) compare these to sex chromosome effects estimated across five rare sex (X/Y) chromosome aneuploidy (SCA) syndromes, and (3) clarify brain size-independent effects of sex and SCA on cerebellar anatomy using a generalizable allometric approach that considers scaling relationships between regional cerebellar volume and brain volume in health. The integration of these approaches shows that (1) sex and SCA effects on raw cerebellar volume are large and distributed, but regionally heterogeneous, (2) human cerebellar volume scales with brain volume in a highly nonlinear and regionally heterogeneous fashion that departs from documented patterns of cerebellar scaling in phylogeny, and (3) cerebellar organization is modified in a brain size-independent manner by sex (relative expansion of total cerebellum, flocculus, and Crus II-lobule VIIIB volumes in males) and SCA (contraction of total cerebellar, lobule IV, and Crus I volumes with additional X- or Y-chromosomes; X-specific contraction of Crus II-lobule VIIIB). Our methods and results clarify the shifts in human cerebellar organization that accompany interwoven variations in sex, sex chromosome complement, and brain size.
Cerebellar systems are implicated in diverse domains of sex-biased behavior and pathology, but we lack a basic understanding of how sex differences in the human cerebellum are distributed and determined. We leverage a rare neuroimaging dataset to deconvolve the interwoven effects of sex, sex chromosome complement, and brain size on human cerebellar organization. We reveal topographically variegated scaling relationships between regional cerebellar volume and brain size in humans, which (1) are distinct from those observed in phylogeny, (2) invalidate a traditional neuroimaging method for brain volume correction, and (3) allow more valid and accurate resolution of which cerebellar subcomponents are sensitive to sex and sex chromosome complement. These findings advance understanding of cerebellar organization in health and sex chromosome aneuploidy.
Aims. Properly characterizing Fabry-Perot interferometers (FPI) is essential for determining their effective properties and evaluating the performance of the astronomical instruments in which they ...are employed. Furthermore, in two-dimensional spectrographs where multiple FPI are used in series, the actual distribution of plate separation errors will be crucial for determining the resulting transmission profiles. We describe techniques that address these issues utilizing the FPI of IBIS, a solar bidimensional spectrometer installed at the Dunn Solar Telescope. Methods. A frequency-stabilized He-Ne laser was used in three different optical layouts to measure the spatially-resolved transmission of the FPI. Analyzing the shape and wavelength shift of the observed profiles allows the characteristics of the cavity errors and the interferometer coating to be determined. Results. We have measured the spatial distribution of the large-scale plate defects, which shows a steep radial trend, as well as the magnitude of the small-scale microroughness. We also extracted the effective reflectivity and absorption of the coating at the laser line wavelength for both interferometers. Conclusions. These techniques, which are generally applicable to any Fabry-Perot interferometer, provide the necessary information for calculating the overall instrumental profile for any illuminated area of the interferometer plates. Accurate knowledge of the spectral transmission profile is important, in particular when using inversion techniques or in comparing observations with simulated data.
Grain sorghum is an important staple food crop grown globally while sweet sorghum is increasingly considered as a promising biofuel feedstock. Biofuels are the major economic products from the ...processing of large quantities of biomass, which is currently being utilized to make value-added products in the biorefinery approach. To date, these value-added products are typically commodity chemicals and waste materials used in agriculture. However, there are opportunities to generate high-value bioactive compounds from sorghum grain and biomass. Chronic diseases, such as cancers, are the top causes for morbidity and mortality in developed nations and are promoted by inflammation and oxidative stress. Globally, colorectal cancer results in approximately one-half million deaths annually. It is estimated that as much as 80% of colorectal cancer cases can be attributed to environmental and dietary factors. The sorghum grain and ligno-cellulosic biomass generated for biofuel production has been reported to be high in bioactive compounds, including phenolic acids and flavonoids, with antioxidant and anti-inflammatory properties. This review focuses on the bioactive compounds of grain and sweet sorghum (Sorghum bicolor L. Moench), for their anti-inflammatory, antioxidant, anti-colon cancer, and immune modulator functions. The review summarizes previous efforts to identify and quantify bioactive compounds in sorghum and documents their anti-cancer biological activities. Finally, this review discusses bioactive compound extraction methodologies and technologies as well as considerations for incorporating these technologies into current biorefining practices.
Aims. Properly characterizing Fabry-Perot interferometers (FPI) is essential for determining their effective properties and evaluating the performance of the astronomical instruments in which they ...are employed. Furthermore, in two-dimensional spectrographs where multiple FPI are used in series, the actual distribution of plate separation errors will be crucial for determining the resulting transmission profiles. We describe techniques that address these issues utilizing the FPI of IBIS, a solar bidimensional spectrometer installed at the Dunn Solar Telescope. Methods. A frequency-stabilized He-Ne laser was used in three different optical layouts to measure the spatially-resolved transmission of the FPI. Analyzing the shape and wavelength shift of the observed profiles allows the characteristics of the cavity errors and the interferometer coating to be determined. Results. We have measured the spatial distribution of the large-scale plate defects, which shows a steep radial trend, as well as the magnitude of the small-scale microroughness. We also extracted the effective reflectivity and absorption of the coating at the laser line wavelength for both interferometers. Conclusions. These techniques, which are generally applicable to any Fabry-Perot interferometer, provide the necessary information for calculating the overall instrumental profile for any illuminated area of the interferometer plates. Accurate knowledge of the spectral transmission profile is important, in particular when using inversion techniques or in comparing observations with simulated data.
Gyrification is a fundamental property of the human cortex that is increasingly studied by basic and clinical neuroscience. However, it remains unclear if and how the global architecture of cortical ...folding varies with 3 interwoven sources of anatomical variation: brain size, sex, and sex chromosome dosage (SCD). Here, for 375 individuals spanning 7 karyotype groups (XX, XY, XXX, XYY, XXY, XXYY, XXXXY), we use structural neuroimaging to measure a global sulcation index (SI, total sulcal/cortical hull area) and both determinants of sulcal area: total sulcal length and mean sulcal depth. We detail large and patterned effects of sex and SCD across all folding metrics, but show that these effects are in fact largely consistent with the normative scaling of cortical folding in health: larger human brains have disproportionately high SI due to a relative expansion of sulcal area versus hull area, which arises because disproportionate sulcal lengthening overcomes a lack of proportionate sulcal deepening. Accounting for these normative allometries reveals 1) brain size-independent sulcal lengthening in males versus females, and 2) insensitivity of overall folding architecture to SCD. Our methodology and findings provide a novel context for future studies of human cortical folding in health and disease.
We use images of high spatial, spectral, and temporal resolution, obtained using both ground- and space-based instrumentation, to investigate the coupling between wave phenomena observed at numerous ...heights in the solar atmosphere. Analysis of 4170 A continuum images reveals small-scale umbral intensity enhancements, with diameters ~0".6, lasting in excess of 30 minutes. We find a maximum waveguide inclination angle of approximately 40degrees between photospheric and chromospheric heights, combined with a radial expansion factor of <76%. Derived kinetic temperature and emission measure time series display prominent out-of-phase characteristics, and when combined with the previously established sub-sonic wave speeds, we conclude that the observed EUV waves are the coronal counterparts of the upwardly propagating magnetoacoustic slow modes detected in the lower solar atmosphere. Thus, for the first time, we reveal how the propagation of 3 minute magnetoacoustic waves in solar coronal structures is a direct result of amplitude enhancements occurring in photospheric UDs.
Chromospheric fibrils are generally thought to trace out low-lying, mainly horizontal magnetic fields that fan out from flux concentrations in the photosphere. A high-resolution (~01 pixel--1) image, ...taken in the core of the Ca II 854.2 nm line and covering an unusually large area, shows the dark fibrils within an active region remnant as fine, looplike features that are aligned parallel to each other and have lengths comparable to a supergranular diameter. Comparison with simultaneous line-of-sight magnetograms confirms that the fibrils are centered above intranetwork areas (supergranular cell interiors), with one end rooted just inside the neighboring plage or strong unipolar network but the other endpoint less clearly defined. Focusing on a particular arcade-like structure lying entirely on one side of a filament channel (large-scale polarity inversion), we find that the total amount of positive-polarity flux underlying this 'fibril arcade' is ~50 times greater than the total amount of negative-polarity flux. Thus, if the fibrils represent closed loops, they must consist of very weak fields (in terms of total magnetic flux), which are interpenetrated by a more vertical field that contains most of the flux. This surprising result suggests that the fibrils in unipolar regions connect the network to the nearby intranetwork flux, while the bulk of the network flux links to remote regions of the opposite polarity, forming a second, higher canopy above the fibril canopy. The chromospheric field near the edge of the network thus has an interlaced structure resembling that in sunspot penumbrae.
Aims.We investigate the oscillatory properties of the quiet solar chromosphere in relation to the underlying photosphere, with particular regard to the effects of the magnetic topology. Methods.For ...the first time we perform a Fourier analysis on a sequence of line-of-sight velocities measured simultaneously in a photospheric (Fe I 709.0 nm) and a chromospheric line (Ca II 854.2 nm). The velocities were obtained from full spectroscopic data acquired at high spatial resolution with the Interferometric BIdimensional Spectrometer (IBIS). The field of view encompasses a full supergranular cell, allowing us to discriminate between areas with different magnetic characteristics. Results.We show that waves with frequencies above the acoustic cut-off propagate from the photosphere to upper layers only in restricted areas of the quiet Sun. A large fraction of the quiet chromosphere is in fact occupied by “magnetic shadows”, surrounding network regions, that we identify as originating from fibril-like structures observed in the core intensity of the Ca II line. We show that a large fraction of the chromospheric acoustic power at frequencies below the acoustic cut-off, residing in the proximity of the magnetic network elements, directly propagates from the underlying photosphere. This supports recent results arguing that network magnetic elements can channel low-frequency photospheric oscillations into the chromosphere, thus providing a way to input mechanical energy in the upper layers.
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