Idiopathic orbital myositis is a subgroup of idiopathic orbital inflammation of unknown etiology that primarily involves extraocular muscles. Orbital myositis most commonly affects young adults in ...the third to fourth decade of life with a female predilection. Imaging is an important diagnostic technique. Inflammatory changes in the tendon and its insertion point to idiopathic orbital myositis. Other inflammatory, endocrine, or neoplastic diseases must be ruled out. We report a case of a 12-year-old girl who presented to the ophthalmologic emergency department with spontaneously developing pain during horizontal eye movement in the left eye and nonspecific symptoms, such as light sensitivity and slightly blurred vision. Her symptoms were nonspecific and physical examination was not diagnostic. However, computed tomography and magnetic resonance imaging of the head revealed isolated, monolateral, and monomuscular lateral rectus myositis as a manifestation of idiopathic orbital inflammation. The patient rapidly responded to systemic corticosteroids. Diagnostic radiology plays a significant role in the unsuspected diagnosis of myositis. Radiologists must be aware of this rare presentation of idiopathic orbital inflammation in preteens.
Background and aim
Binary copper-cobalt oxide nanoparticles (CuO\CoO NPs) are modern kinds of antimicrobials, which may get a lot of interest in clinical application. This study aimed to detect the ...effect of the binary CuO\CoO NPs on the expression of
papC
and
fimH
genes in multidrug-resistant (MDR) isolates of
Klebsiella oxytoca
to reduce medication time and improve outcomes.
Methods
Ten isolates of
K. oxytoca
were collected and identified by different conventional tests besides PCR. Antibiotic sensitivity and biofilm-forming ability were carried out. The harboring of
papC
and
fimH
genes was also detected. The effect of binary CuO\CoO nanoparticles on the expression of
papC
and
fimH
genes was investigated.
Results
Bacterial resistance against cefotaxime and gentamicin was the highest (100%), while the lowest percentage of resistance was to amikacin (30%). Nine of the ten bacterial isolates had the ability to form a biofilm with different capacities. MIC for binary CuO\CoO NPs was 2.5 µg/mL. Gene expression of
papC
and
fimH
was 8.5- and 9-fold lower using the NPs.
Conclusion
Binary CuO\CoO NPs have a potential therapeutic effect against infections triggered by MDR
K. oxytoca
strains due to the NPs-related downregulation ability on the virulence genes of
K. oxytoca
.
Introduction: Burns are common medical infections that examined in hospitals. Cytokines are produced by innate immune response; cytokines determine the type of adaptive immune response. This study ...aims to screen and evaluate the role of IL-2 and IL-6 levels in the serum of patients who have suffered from burns by ELISA technique. Methods: Seventy serum samples were collected from burned patients in Baghdad city hospitals and tested by ELISA technique to detect IL-2 and IL-6 levels. Results: Shows great differences in IL-2 level of male patients (30.16 pg/ml) compared to males control group by an average of (29.66 pg/ml). While IL-6 shows significant differences in female patients with range (63.39 pg/ml) and male (66.47 pg/ml) compared to females control group (2.48 pg/ml) and males (22.80 pg/ml). Moreover cytokines shows significant differences between the three age groups of burned patients in comparison with the control group. In conclusion the result of present study showed significant difference in level of some cytokines IL-2,IL-6 for patients with burns. Conclusion: the result of present study showed significant difference in level of some cytokines IL-2, IL-6 for patients with burns.
Introduction: Klebsilla pneumoniae is one of must opportunistic pathogens that causes nosocomial infection, UTI, respiratory tract infections and blood infections. ZrO2 nanoparticles have ...antimicrobial activity against some pathogenic bacteria and fungi. Ceftazidime is one of third generation cephalosporins groups of antibiotecs, characterized by its broad spectrum on bacteria in general and particularly on Enterobacteriaceae family like Klebsiella spp.
Method: Diverse clinical samples of Klebsilla pneumoniae were isolated from several hospitals in Baghdad – Iraq and ZrO2 nanoparticles was investigated against it. Ceftazidime was also investigated against K. pneumoniae. Both of ZrO2 nanoparticles and ceftazidime were mixed together and investigated against K. pneumoniae.
Results: The result showed that ZrO2 nanoparticles were effectivity on inhibiting opportunistic pathogens. By using zirconium oxide nanoparticles on Klebsiella pneumonia isolates in 24h. of incubation time, inhibition zones were (38,34,10,10,8,0) mm respectively on agar plates. By using ceftazidime alone against the same bacteria inhibition zones were (40,32,10,9,8,0) mm. respectively.
Conclusion:The present study results that the antibacterial activity of ceftazidime against bacteria was increased when combination between ZrO2 nanoparticles and the antibiotic had done, because, inhibition zones in case of mixing both of ZrO2 nanoparticles and ceftazidime were (43,40,12,12,10,0) mm respectively. So that we can conclude that the combination of zirconium oxide nanoparticles (ZrO2)
and ceftazidime was a useful method for the treatment of Klebsilla pneumonia that cause nosocomial infection, UTI, respiratory tract infections and blood infections.
Introduction: Klebsiella pneumoniae are Gram-negative which cause many diseases such as urinary tract infections, respiratory tract infections and septicemia. Inulinase is an enzyme used in food ...manufacture and pharmaceuticals. Inulinase is used in decreasing lipid ratio and, cholesterol in blood and considered as a prebiotic factor inside intestine. Many microorganisms can produce inulinase, such as yeast, fungi and bacteria; among such bacteria: Bacillus spp., Arthrobacter spp., and Pseudomonas spp. but there are no studies about inulinase production by K. pneumoniae have been reported. So the current study aims at investing the ability of producing and purification inulinase by K. pneumoniae. Method: K. pneumoniae were isolated from many hospitals and screened for the production of inulinase. Isolation percentage was 32%. A combination between the enzyme and the ceftazidime were assayed for detecting the antibacterial activity agonist Gram positive and Gram negative bacteria were done. Results: It is found that K. pneumoniae K4 isolate is the best producer of this enzyme. Inulinase, purified with ammonium sulfate at 70% saturation with specific activity 7.01 U/mg protein. As well, it's found that inulinase had increased the activity of ceftazidime against bacteria when combination between this enzyme and the antibiotic had done. Conclusion: This study proves for the first time that K. pneumoniae can produce inulinase which can be used in tremendous applications and also proves the broad spectrum bioactivity of inulinase against microbial pathogens. Ceftazidime antimicrobial activity against bacteria, is increased when a combination between inulinase and ceftazidime had done.
To assess the prescribing practice of enoxaparin in comparison to dosing guidelines.
A prospective observational chart review of patients who received enoxaparin for the treatment of thrombosis at ...Dunedin Public Hospital between August 2007 and January 2008. Deviations in dose from guidelines were defined and recorded along with various clinical and demographic data of participants.
Fifty-nine patients (62 admissions) were recruited. Dose deviations occurred on 19 (30.7%) occasions. More dose deviations occurred at or close to guideline transition points (total body weight over 90 kg and/or creatinine clearance between 20-40 mL/min).
Current enoxaparin dosing guidelines are too simplistic and result in discord between dosing in practice and that approved by Medsafe.
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