Learning capabilities have been an essential element for the success of second language learners that needs regulators' and researchers' emphasis. Hence, the current research examines the role of ...lack of self-efficacy and resistance to innovation on the insufficient learning capabilities of second language students in China. The current study also examines the mediating role of demotivation among the linkage of lack of self-efficacy, resistance to innovation, and insufficient learning capabilities and explores the moderating role of institutional culture among demotivation and insufficient learning capabilities. The researchers have applied the questionnaires method to gather the data from selected students and employed the smart-PLS to assess the measurement and structural models. The results revealed that lack of self-efficacy and resistance to innovation has a significant and positive linkage with insufficient learning capabilities. The results also exposed that demotivation significantly mediates among lack of self-efficacy, resistance to innovation, and insufficient learning capabilities. The findings also explored that the institutional culture significantly moderates the linkage between demotivation and insufficient learning capabilities.
There are more than 1000 microbial species living in the complex human intestine.The gut microbial community plays an important role in protecting the host against pathogenic microbes,modulating ...immunity,regulating metabolic processes,and is even regarded as an endocrine organ.However,traditional culture methods are very limited for identifying microbes.With the application of molecular biologic technology in the field of the intestinal microbiome,especially metagenomic sequencing of the next-generation sequencing technology,progress has been made in the study of the human intestinal microbiome.Metagenomics can be used to study intestinal microbiome diversity and dysbiosis,as well as its relationship to health and disease.Moreover,functional metagenomics can identify novel functional genes,microbial pathways,antibiotic resistance genes,functional dysbiosis of the intestinal microbiome,and determine interactions and co-evolution between microbiota and host,though there are still some limitations.Metatranscriptomics,metaproteomics and metabolomics represent enormous complements to the understanding of the human gut microbiome.This review aims to demonstrate that metagenomics can be a powerful tool in studying the human gut microbiome with encouraging prospects.The limitations of metagenomics to be overcome are also discussed.Metatranscriptomics,metaproteomics and metabolomics in relation to the study of the human gut microbiome are also briefly discussed.
Unlike afterglow phosphors, transparent crystals free of scattering issues hold great potential in applications such as volumetric displays and three‐dimensional encryption. Here, a double‐perovskite ...host of ca. 85 % transparency, a Cs2NaScCl6 single crystal, was grown in aqueous solution. Through heavy doping of Tb ions, the crystal exhibited a high photoluminescence quantum yield (PL QY) up to 98.2 %. Both steady‐state and transient PL spectroscopic investigation revealed a cross‐relaxation efficiency (ηCR≈99 %) between Tb ions, greatly mitigated the electron saturation on the 5D3 level and encouraged the radiative route against quenching. The doped crystal displayed an intense afterglow of up to 12 h after ceasing the X‐ray excitation, allowing it to be used in a radiation‐storage battery which has a linear scaling capacity with loading weight. Our work opens possibilities in photo‐stimulated volumetric display and three‐dimensional information storage.
Transparent Cs2NaSc1−xCl6:xTb3+ single crystals with ca. 98.2 % photoluminescence quantum yield (PL QY) were grown by a hydrothermal method. The doped crystal exhibited an intense green afterglow of 12 hours upon ceasing the X‐ray excitation. Based on this improved output of the transparent crystals, a radiation‐storage battery was designed, which has a linear‐scaling capacity with loading weight.
Strokes are among the leading conditions that lead to disability and death. Currently, there is a lack of ideal nursing care for stroke patients. The aim of this study is to assess the effect of ...combining evidence-based nursing and clinical nursing pathway to establish a nursing model to provide care for patients who suffered a stroke.
A comprehensive search of online-based databases will be carried out to identify relevant publications, the databases include EMBASE, Cochrane Library, PubMed, VIP databases, Chinese National Knowledge Infrastructure, and WanFang database. The search will consider all Randomized Controlled Trials, interrupted time series studies, and controlled before and after studies, all related to providing care for neurology and strokes by combining evidence-based nursing and clinical nursing pathway to elevate access and outcomes for patients with stroke. The language of publications will be restricted to English and Chinese. The author will select studies, extract data, and evaluate the quality of the involved articles. RevMan 5.3 software will be employed to perform all statistical analysis.
The outcomes of the proposed study will provide scientific evidence for the nursing care of evidence-based nursing combined with clinical nursing pathway for stroke patients.
The planned systematic analysis will be first to examine the effect of combining evidence-based nursing and clinical nursing pathway to present a nursing model to treat stroke patients.
November 16, 2021.osf.io/6zr5a/. (https://osf.io/6zr5a/).
This is the first report of full‐color afterglow composites composed of four multicolored (blue, green, orange, and red) carbon dots (CDs) in polyacrylamide (PAM) matrix. Thus, adjustable four‐color ...room‐temperature phosphorescence (RTP) CDs@PAM composites are prepared on a PAM platform. The abundant amide groups in PAM are connected to the functional groups in CDs by hydrogen bonds, which promote the intersystem crossover and inhibit the non‐radiative relaxation of triple states (T1) in CDs@PAM and effectively shield the quenching agents such as oxygen. Furthermore, the rigid hydrogen bond mesh structure is beneficial to the stability of T1 in CDs@PAM. In addition, the results of electron spin resonance reveal that the afterglow of CDs@PAM composites is not caused by oxygen defects and the increase of oxygen defects hinders the emission of phosphorescence. The CDs@PAM composites display not only multi‐color fluorescence from blue to red, but also display full‐color RTP emission from blue to red with average phosphorescence lifetime in the range of 637–478.97 ms. These composites, in addition to the full‐color RTP performance, are promising for multi‐color pattern anti‐counterfeiting and information encryption.
Full‐color (blue, green, yellow, and red) room‐temperature phosphorescence (RTP) composites have been composed of four multicolored carbon dots (CDs) (blue, green, orange, and red) in a polyacrylamide (PAM) matrix. The abundant amide groups in PAM are connected to the functional groups in CDs by hydrogen bonds. These composites, in addition to the full‐color RTP performance, are promising for multi‐color pattern anti‐counterfeiting and information encryption.
Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis. Resistance to targeted therapeutic drugs such as sorafenib remains one of the major ...challenges in clinical treatment. In the present study, PARP1 was found to be highly expressed in human embryonic stem cells, but progressively decreased upon specified hepatic differentiation. Reactivation of PARP1 expression was also detected in HCC residual tumors after sorafenib treatment in xenograft mouse model, indicating the potential important roles of PARP1 in stem cell pluripotency and HCC sorafenib treatment resistance. Overexpression of PARP1 was frequently observed in HCC patients, and closely associated with poor clinical outcome. Treatment of Sorafenib induced activation of DNA damage repair signaling, which is highly active and essential for maintenance of stem cell pluripotency in HCC residual tumors. PARP inhibitor Olaparib extensively suppressed the DNA damage repair signaling, and significantly inhibited the global pluripotent transcriptional network. The repression of key pluripotent transcriptional factors and DNA damage repair signaling by Olaparib was mainly through CHD1L-mediated condensation of the chromatin structure at their promotor regions. The global reshaping of the pluripotent transcriptome by Olaparib might reinforce Sorafenib in eliminating HCC residual tumors and enhance therapeutic efficiency.
Studies of Late Quaternary geological slip-rates and the GPS decadal slip-rates along the major strike-slip faults in the northern margin of the Tibetan Plateau show that slip-rates remain relatively ...constant along the middle sections of each fault and decrease rapidly toward the ends. Our recent studies suggest that the slip rates are low (<10mm/yr) along the major strike-slip faults, i.e., Altyn-Tagh fault and Qilian-Haiyuan fault. West of 95°E, the slip rate on the Altyn-Tagh fault has been determined to be 8–12mm/yr, and gradually decreases from 95°E eastward to about 1–2mm/yr at the easternmost segment of the fault. The slip-rate of Qilian-Haiyuan fault is about 1–2mm/yr near the Halahu Lake, near the western tip of the fault, then increases to a relatively constant value of 4–5mm/yr in the Qilian area (101°E and eastward). Eastward, the fault merges into the NS trending Liupan Shan fault zone east of Haiyuan, and the slip rate drops to 1–3mm/yr, or even lower. Our present observations on the variation and distribution of slip rates along the major strike slip faults indicate that slip on the Altyn-Tagh fault is mainly dissipated through internal deformation, by thrust faulting within the Qilian Shan and shortening within the adjacent Cenozoic basins. Left-lateral strike-slip on the Qilian-Haiyuan fault might be transformed into shortening and growth of the Liupan Shan to the east, and may also contribute partially to the deformation in the western Qilian Shan. In conclusion, the distribution of slip rates from both late Quaternary geological records and the current GPS observations suggest a decrease in slip rate, a redistribution of strain, and the transformation of displacement along the major strike slip faults into crustal shortening, basin formation and mountain uplift that characterize present-day deformation of the northern margin of the Tibetan Plateau.
►Slip rates of faults are jointly determined by geological and geodetic methods. ►Boundary faults of northern Tibet slip at very low rate of less than 10mm/a. ►Sharp tapers of slip rate are found at the ends of these boundary faults. ►Slips on boundary faults are dissipated by thrust faulting and basin shortening. ►Present-day deformation of north Tibet margin is featured by this dissipation.
We report the growth of a halide‐based double perovskite, Cs2NaxAg1−xInCl6:y%Mn, via a facile hydrothermal reaction at 180 °C. Through a co‐doping strategy of both Na+ and Mn2+, the as‐prepared ...crystals exhibited a red afterglow featuring a high color purity (ca. 100 %) and a long duration time (>5400 s), three orders of magnitude longer than those solution‐processed organic afterglow crystals. The energy transfer (ET) process between self‐trapped excitons (STE) and activators was investigated through time‐resolved spectroscopy, which suggested an ET efficiency up to 41 %. Importantly, the nominal concentration of dopants, especially in the case of Na+, was found a useful tool to control both energy level and number distribution of traps. Cryogenic afterglow measurements suggested that the afterglow phenomenon was likely governed by thermal‐activated exciton diffusion and electron tunneling process.
We report the growth of a halide‐based double perovskite, Cs2NaxAg1−xInCl6:y%Mn, via a facile hydrothermal reaction at 180 °C. Through a co‐doping strategy of both Na+ and Mn2+, the as‐prepared crystals exhibited a red afterglow featuring a high color purity (ca. 100 %) and a long duration time (>5400 s), three orders of magnitude longer than those solution‐processed organic afterglow crystals.
Extensive studies have been conducted on gene biomarkers by exploring the increasingly accumulated gene expression and sequence data generated from high‐throughput technology. Here, we briefly report ...on the state‐of‐the‐art research and application of biomarkers from single genes (i.e. gene biomarkers) to gene sets (i.e. group or set biomarkers), gene networks (i.e. network biomarkers) and dynamical gene networks (i.e. dynamical network biomarkers). In particular, differential and dynamical network biomarkers are used as representative examples to demonstrate their effectiveness in both detecting early signals for complex diseases and revealing essential mechanisms on disease initiation and progression at a network level.
Here, we briefly report on the state‐of‐the‐art research and application of biomarkers from single genes to gene sets, gene networks and dynamical gene networks, which explore the increasingly‐accumulated gene expression and sequence data. Differential network biomarkers and dynamical network biomarkers are used as representative examples to demonstrate their effectiveness on detecting early signals for complex diseases and revealing essential pathogen mechanisms.
Bernal‐stacked bilayer germanene with a stable buckled honeycomb structure has been successfully synthesized on Cu(111). Structural and electronic characterizations as well as theoretical ...calculations unequivocally demonstrate for the first time the presence of a nearly linear energy dispersion in the vicinity of the Fermi energy, as expected of the Dirac signature for theoretical freestanding germanene.
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