We have identified 453 compact dense cores in 3 mm continuum emission maps in the ATOMS (ALMA Three-millimeter Observations of Massive Star-forming regions) survey, and compiled three catalogues of ...high-mass star forming cores. One catalogue, referred to as H/UC-HII catalogue, includes 89 cores that enshroud hyper/ultra compact (H/UC) HII regions as characterized by associated compact H40alpha emission. A second catalogue, referred to as pure s-cHMC, includes 32 candidate Hot Molecular Cores (HMCs) showing rich spectra (N>20lines) of complex organic molecules (COMs) but not associated with H/UC-HII regions. The third catalogue, referred to as pure w-cHMC, includes 58 candidate HMCs with relatively low levels of COM richness and not associated with H/UC-HII regions. These three catalogues of dense cores provide an important foundation for future studies of the early stages of high-mass star formation across the Milky Way. We also find that nearly half of H/UC-HII cores are candidate HMCs. From the number counts of COM-containing and H/UC-HII cores, we suggest that the duration of high-mass protostellar cores showing chemically rich features is at least comparable to the lifetime of H/UC-HII regions. For cores in the H/UC-HII catalogue, the width of the H40alpha line increases as the core size decreases, suggesting that the non-thermal dynamical and/or pressure line-broadening mechanisms dominate on the smaller scales of the H/UC-HII cores.
The structural and thermodynamic properties of pure water and sodium chloride solutions at high temperatures and pressures are studied by using molecular dynamics simulations and quantum molecular ...simulations. Properties are calculated as functions of temperature and pressure. The results show that the structure of pure water becomes looser as temperature increases from 298 to 400 K, with the collapse of the traditional tetrahedral structure. For sodium chloride solutions, the same collapse is also found with the increased concentration. Moreover, a critical point for the diffusion coefficient of
and
is evident when the temperature increases linearly under 100 atm. At the critical points, the ions are abnormally clustered, due to the weakly hydrogen-bonded water molecules. The cluster size of the ions is synchronous with the corresponding diffusion coefficients.
Nitrogen-doped graphene aerogels-supported NiS sub(2) nanoparticles (NiS sub(2)/NG) were synthesized by a one-pot hydrothermal method. In the process, l-cysteine was used not only as the nitrogen ...source to form the nitrogen-doped graphene aerogels, but also the sulfur source to form NiS sub(2). The nitrogen-doped graphene (NG) hybrids show an interconnected reticulation of NG sheets with uniform deposition of NiS sub(2) NPs, and the NiS sub(2) NPs are deposited on the NG layers. In studying the effects of the NG and NiS sub(2)/NG for the ORR, we found that NiS sub(2)/NG shows a more positive onset potential, higher current density, and higher electron transfer number (4) for the oxygen-reduction reaction (ORR) in alkaline media than NG. Furthermore, NiS sub(2)/NG shows better durability and methanol tolerance than the commercial Pt/C catalyst.
Nitrogen-doped graphene aerogels-supported NiS^sub 2^ nanoparticles (NiS^sub 2^/NG) were synthesized by a one-pot hydrothermal method. In the process, l-cysteine was used not only as the nitrogen ...source to form the nitrogen-doped graphene aerogels, but also the sulfur source to form NiS^sub 2^. The nitrogen-doped graphene (NG) hybrids show an interconnected reticulation of NG sheets with uniform deposition of NiS^sub 2^ NPs, and the NiS^sub 2^ NPs are deposited on the NG layers. In studying the effects of the NG and NiS^sub 2^/NG for the ORR, we found that NiS^sub 2^/NG shows a more positive onset potential, higher current density, and higher electron transfer number (4) for the oxygen-reduction reaction (ORR) in alkaline media than NG. Furthermore, NiS^sub 2^/NG shows better durability and methanol tolerance than the commercial Pt/C catalyst.PUBLICATION ABSTRACT
Severe fever with thrombocytopenia syndrome is caused by infection with the severe fever with thrombocytopenia syndrome virus.
Between April 2011 and December 2019, data on consecutive patients who ...were diagnosed with severe fever with thrombocytopenia syndrome were prospectively collected from five medical centers in China. The score of the death risk model was correlated with the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio. Multivariable Cox analyses were used to identify the independent factors associated with mortality.
During the study period, 763 patients were diagnosed with severe fever with thrombocytopenia syndrome; 415 of these patients were enrolled in our study. We found that the neutrophil-to-lymphocyte ratio of the group that died was significantly higher on admission (P=0.007) than that of the group that survived, and the neutrophil-to-lymphocyte ratio showed a positive correlation with the score of the death risk model. Multivariate Cox regression suggested that a neutrophil-to-lymphocyte ratio greater than 5.4 was an independent risk factor for survival time (HR=6.767, P=0.011). Platelet-to-lymphocyte ratio did not show a special role in this study.
A neutrophil-to-lymphocyte ratio greater than 5.4 can increase the risk of death and decrease the survival time of patients. In summary, the neutrophil-to-lymphocyte ratio provides a supplementary means for effectively managing severe fever with thrombocytopenia syndrome (SFTS).
We report studies of the relationships between the total bolometric luminosity (L bol or L TIR) and the molecular line luminosities of J = 1 − 0 transitions of H 13 CN, H 13 CO + , HCN, and HCO + ...with data obtained from ACA observations in the "ATOMS" survey of 146 active Galactic star forming regions. The correlations between L bol and molecular line luminosities L mol of the four transitions all appear to be approximately linear. Line emission of isotopologues shows as large scatters in L bol-L mol relations as their main line emission. The log(L bol /L mol) for different molecular line tracers have similar distributions. The L bol-to-L mol ratios do not change with galactocentric distances (R GC) and clump masses (M clump). The molecular line luminosity ratios (HCN-to-HCO + , H 13 CN-to-H 13 CO + , HCN-to-H 13 CN and HCO +-to-H 13 CO +) all appear constant against L bol , dust temperature (T d), M clump and R GC. Our studies suggest that both the main lines and isotopologue lines are good tracers of the total masses of dense gas in Galactic molecular clumps. The large optical depths of main lines do not affect the interpretation of the slopes in star formation relations. We find that the mean star formation efficiency (SFE) of massive Galactic clumps in the "ATOMS" survey is reasonably consistent with other measures of the SFE for dense gas, even those using very different tracers or examining very different spatial scales.
Although thrombocytosis has been reported in a variety of cancer types, the standard of thrombocytosis in gastric cancer (GC) and the association between thrombocytosis and the clinicopathological ...features of patients with GC remain unclear. In the present study, 1,763 GC patients were retrospectively filtered by preoperative thrombocytosis and compared with control group A (n=107) that had benign gastric lesions and control group B (n=100) that were GC patients with a normal platelet (PLT) count. Associations between clinical variables and preoperative PLT counts were assessed by univariate and multivariate analyses. Kaplan-Meier survival curves and Cox regression were used to evaluate the effect of thrombocytosis on prognosis. Sensitivities and specificities of the PLT counts in predicting recurrence were analyzed via area under the receiver operating characteristic curve (AUROC). The results indicated that the incidence of thrombocytosis in GC patients was higher than in benign gastric lesion patients, with 4.03% of GC patients having a PLT count >400×109/l (P=0.014) and 12.08% had a PLT count >300×109/l (P<0.001). For the patients with a PLT count >400×109/l, the frequency of abnormal PLT counts in GC correlated with tumor size (P<0.001), tumor, node and metastasis (TNM) classification (P=0.002), invasive degree (P=0.003) and D-dimer (P=0.013) and fibrinogen concentrations (P=0.042). Tumor size (P=0.002), TNM classification (P<0.001) and depth of penetration (P=0.001) were independent factors for thrombocytosis. However, thrombocytosis functioned as an independent prognostic factor for GC patients with a PLT count >400×109/l (relative risk, 1.538; 95% confidence interval, 1.041-2.271). In the majority of patients (17/24) with a high preoperative PLT count that decreased to a normal level following resection, PLT levels increased again at recurrence. Sensitivities and specificities of thrombocytosis for recurrence in those patients were 70.8 and 83.3%, respectively (AUROC, 0.847; P=0.01). Therefore, a PLT count of 400×109/l is a suitable threshold for defining thrombocytosis in GC. Thrombocytosis was shown to affect the blood hypercoagulable state and also have a negative prognostic value for GC patients. PLT monitoring following surgery was useful to predict the recurrence for specific GC patients that suffered preoperative thrombocytosis but had restored PLT levels following resection.
The cross-electrophile couplings of readily available aryl fluorosulfates with vinyl chlorosilanes could be successfully achieved by using nickel as transition metal catalyst and manganese as ...reductant, which proceeded smoothly at room temperature via C-O bond activation to give a series of structurally varied aryl silanes in moderate to good yields. The reactions not only displayed broad substrate scope and good functional group compatibility, but also could be subjected to scale-up synthesis and be applied to late-stage functionalization of biologically active molecules.
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•Cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes could be successfully achieved.•A variety of aryl silanes could be obtained in modest to high yields with wide functional group compatibility.•The reactions proceeded via C-O bond activation of easily available aryl fluorosulfates at room temperature.•The protocol could be applied to gram-scale synthesis and late-stage modification of bioactive molecules.
An efficient cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes by using nickel as transition metal catalyst and manganese as reductant has been achieved. The reactions proceeded smoothly at room temperature via C-O bond activation to give a series of structurally varied aryl silanes in moderate to good yields, displaying broad substrate generality and good functional group compatibility. In addition, the reaction could be subjected to scale-up synthesis and be applied to late-stage functionalization of biologically active molecules.
To adopt a criterion summarized in long-term practice to judge the immune status of recurrent aphthous ulceration (RAU) patients, and to analyze its rationality and feasibility.
60 cases were ...included, whose clinical information, such as age, sex, constitution status, history of system diseases and severity of ulceration were collected. The subjective judgement results of the immune status were obtained according to the criterion summarized in clinical practice. At the same time, peripheral blood parameters about immune function were examined in order to obtain the objective examination results of the immune status. With the examination result as the gold standard, the rationality of the criterion was estimated through its sensitivity and specificity.
According to subjective judgment, there were 86.67% cases with abnormal immune status (28.33% cases with elevated immune status, and 58.33% cases with reduced immune status). According to objective examination, there were 93.33% cases with abnormal immune status
We report studies of the relationships between the total bolometric luminosity (\(L_{\rm bol}\) or \(L_{\rm TIR}\)) and the molecular line luminosities of \(J=1-0\) transitions of H\(^{13}\)CN, ...H\(^{13}\)CO\(^+\), HCN, and HCO\(^+\) with data obtained from ACA observations in the "ATOMS" survey of 146 active Galactic star forming regions. The correlations between \(L_{\rm bol}\) and molecular line luminosities \(L'_{\rm mol}\) of the four transitions all appear to be approximately linear. Line emission of isotopologues shows as large scatters in \(L_{\rm bol}\)-\(L'_{\rm mol}\) relations as their main line emission. The log(\(L_{\rm bol}\)/\(L'_{\rm mol}\)) for different molecular line tracers have similar distributions. The \(L_{\rm bol}\)-to-\(L'_{\rm mol}\) ratios do not change with galactocentric distances (\(R_{\rm GC}\)) and clump masses (\(M_{\rm clump}\)). The molecular line luminosity ratios (HCN-to-HCO\(^+\), H\(^{13}\)CN-to-H\(^{13}\)CO\(^+\), HCN-to-H\(^{13}\)CN and HCO\(^+\)-to-H\(^{13}\)CO\(^+\)) all appear constant against \(L_{\rm bol}\), dust temperature (\(T_{\rm d}\)), \(M_{\rm clump}\) and \(R_{\rm GC}\). Our studies suggest that both the main lines and isotopologue lines are good tracers of the total masses of dense gas in Galactic molecular clumps. The large optical depths of main lines do not affect the interpretation of the slopes in star formation relations. We find that the mean star formation efficiency (SFE) of massive Galactic clumps in the "ATOMS" survey is reasonably consistent with other measures of the SFE for dense gas, even those using very different tracers or examining very different spatial scales.
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