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  • Peripheral CD8 + T cell cha... Peripheral CD8 + T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma
    Fairfax, Benjamin P; Taylor, Chelsea A; Watson, Robert A ... Nature medicine, 02/2020, Volume: 26, Issue: 2
    Journal Article
    Peer reviewed
    Open access

    Immune checkpoint blockade (ICB) of PD-1 and CTLA-4 to treat metastatic melanoma (MM) has variable therapeutic benefit. To explore this in peripheral samples, we characterized CD8 T cell gene ...
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  • Context-specific regulation... Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
    Al-Mossawi, Hussein; Yager, Nicole; Taylor, Chelsea A ... Nature communications, 10/2019, Volume: 10, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    IL-7 is a key factor in T cell immunity and common variants at IL7R, encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA is induced in stimulated monocytes, yet a ...
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  • Better Measurement for Perf... Better Measurement for Performance Improvement in Low- and Middle-Income Countries: The Primary Health Care Performance Initiative (PHCPI) Experience of Conceptual Framework Development and Indicator Selection
    VEILLARD, JEREMY; COWLING, KRYCIA; BITTON, ASAF ... The Milbank quarterly, 12/2017, Volume: 95, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    Context: The Primary Health Care Performance Initiative (PHCPI), a collaboration between the Bill and Melinda Gates Foundation, The World Bank, and the World Health Organization, in partnership with ...
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  • Natural Killer cells demons... Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity
    Gilchrist, James J.; Makino, Seiko; Naranbhai, Vivek ... Nature communications, 07/2022, Volume: 13, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    Abstract Natural Killer cells are innate lymphocytes with central roles in immunosurveillance and are implicated in autoimmune pathogenesis. The degree to which regulatory variants affect Natural ...
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  • IL7 genetic variation and t... IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
    Taylor, Chelsea A; Watson, Robert A; Tong, Orion ... Nature medicine, 12/2022, Volume: 28, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for melanoma, we observed ...
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  • Checkpoint-blocker-induced ... Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles
    Ye, Weiyu; Olsson-Brown, Anna; Watson, Robert A ... British journal of cancer, 05/2021, Volume: 124, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    Immune checkpoint blockers (ICBs) activate CD8 T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical ...
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  • Evaluation of a pilot, comm... Evaluation of a pilot, community-led mental illness de-stigmatization theater intervention in rural uganda
    Lee, Yang Jae; Rauben, Kazungu; Liu, Curtis ... BMC psychiatry, 12/2022, Volume: 22, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    In rural areas of low- and middle- income countries, mental health care is often unavailable and inaccessible, and stigma is a major barrier to treatment. Destigmatization can increase ...
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  • Severe acute myositis and m... Severe acute myositis and myocarditis on initiation of 6-weekly pembrolizumab post-COVID-19 mRNA vaccination
    Watson, Robert A; Ye, Weiyu; Taylor, Chelsea A ... Journal for immunotherapy of cancer, 04/2024, Volume: 12, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    We describe three cases of critical acute myositis with myocarditis occurring within 22 days of each other at a single institution, all within 1 month of receiving the initial cycle of the anti-PD-1 ...
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  • Immune checkpoint blockade ... Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity
    Watson, Robert A; Tong, Orion; Cooper, Rosalin ... Science immunology, 10/2021, Volume: 6, Issue: 64
    Journal Article
    Peer reviewed
    Open access

    The antitumor action of immune checkpoint blockade (ICB) is primarily mediated by CD8 T cells. How sensitivity to ICB varies across CD8 T cell subsets and clonotypes and the relationship of these ...
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  • TGF-β1 potentiates Vγ9Vδ2 T... TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer
    Beatson, Richard E.; Parente-Pereira, Ana C.; Halim, Leena ... Cell reports medicine, 12/2021, Volume: 2, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells are expanded in ...
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