ABSTRACT We present results of a stellar occultation by the Jupiter Trojan asteroid Patroclus and its nearly equal size moon, Menoetius. The geocentric mid-time of the event was 2013 October 21 ...06:43:02 UT. Eleven sites out of 36 successfully recorded an occultation. Seven chords across Patroclus yielded an elliptical limb fit of 124.6 by 98.2 km. There were six chords across Menoetius that yielded an elliptical limb fit of 117.2 by 93.0 km. There were three sites that got chords on both objects. At the time of the occultation we measured a separation of 664.6 km (0.247 arcsec) and a position angle for Menoetius of 265 7 measured eastward from J2000 north. Combining this occultation data with previous light curve data, the axial ratios of both objects are 1.3 : 1.21 : 1, indicative of a mostly oblate ellipsoid with a slight asymmetry in its equatorial projection. The oblate shape is not an equilibrium shape for the current rotation period, but would be if it were rotating with an ∼8 h period. This faster period is consistent with a pre-evolved state of the system with an orbital separation that is 50% smaller. Our best estimate of the system density is 0.88 g cm−3.
Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, ...zoliflodacin was evaluated for the treatment of uncomplicated gonorrhea.
We randomly assigned eligible men and women who had signs or symptoms of uncomplicated urogenital gonorrhea or untreated urogenital gonorrhea or who had had sexual contact in the preceding 14 days with a person who had gonorrhea to receive a single oral dose of zoliflodacin (2 g or 3 g) or a single 500-mg intramuscular dose of ceftriaxone in a ratio of approximately 70:70:40. A test of cure occurred within 6±2 days after treatment, followed by a safety visit 31±2 days after treatment. The primary efficacy outcome measure was the proportion of urogenital microbiologic cure in the microbiologic intention-to-treat (micro-ITT) population.
From November 2014 through December 2015, a total of 179 participants (167 men and 12 women) were enrolled. Among the 141 participants in the micro-ITT population who could be evaluated, microbiologic cure at urogenital sites was documented in 55 of 57 (96%) who received 2 g of zoliflodacin, 54 of 56 (96%) who received 3 g of zoliflodacin, and 28 of 28 (100%) who received ceftriaxone. All rectal infections were cured in all 5 participants who received 2 g of zoliflodacin and all 7 who received 3 g, and in all 3 participants in the group that received ceftriaxone. Pharyngeal infections were cured in 4 of 8 participants (50%), 9 of 11 participants (82%), and 4 of 4 participants (100%) in the groups that received 2 g of zoliflodacin, 3 g of zoliflodacin, and ceftriaxone, respectively. A total of 84 adverse events were reported: 24 in the group that received 2 g of zoliflodacin, 37 in the group that received 3 g of zoliflodacin, and 23 in the group that received ceftriaxone. According to investigators, a total of 21 adverse events were thought to be related to zoliflodacin, and most such events were gastrointestinal.
The majority of uncomplicated urogenital and rectal gonococcal infections were successfully treated with oral zoliflodacin, but this agent was less efficacious in the treatment of pharyngeal infections. (Funded by the National Institutes of Health and Entasis Therapeutics; ClinicalTrials.gov number, NCT02257918 .).
Data from DNA genotyping via a 96-SNP panel in a study of 25,015 clinical samples were utilized for quality control and tracking of sample identity in a clinical sequencing network. The study aimed ...to demonstrate the value of both the precise SNP tracking and the utility of the panel for predicting the sex-by-genotype of the participants, to identify possible sample mix-ups.
Precise SNP tracking showed no sample swap errors within the clinical testing laboratories. In contrast, when comparing predicted sex-by-genotype to the provided sex on the test requisition, we identified 110 inconsistencies from 25,015 clinical samples (0.44%), that had occurred during sample collection or accessioning. The genetic sex predictions were confirmed using additional SNP sites in the sequencing data or high-density genotyping arrays. It was determined that discrepancies resulted from clerical errors (49.09%), samples from transgender participants (3.64%) and stem cell or bone marrow transplant patients (7.27%) along with undetermined sample mix-ups (40%) for which sample swaps occurred prior to arrival at genome centers, however the exact cause of the events at the sampling sites resulting in the mix-ups were not able to be determined.
Lunar geochemical groups such as Mg suite, ferroan anorthosite, and alkali suite rocks are difficult to distinguish from orbit because they are defined by both modal mineralogy and elemental ...composition of their constituent minerals. While modal mineralogy can be modeled, only specific minerals or elements can be directly detected. At near‐infrared (NIR) wavelengths, pyroxenes are among the most spectrally distinctive minerals, and their absorption bands are sensitive to structure and composition. Pyroxenes thus provide important clues to distinguish these geochemical groups and to understand lunar crustal evolution. Using Moon Mineralogy Mapper data, we search for lithologies dominated by strong low‐calcium pyroxene (LCP) signatures. We compare the NIR absorptions of 20 LCPs to a suite of synthetic pyroxenes to determine which lunar pyroxenes appear magnesian enough to be candidate Mg suite norites. We detail three prominent regions of LCP (1) in South Pole–Aitken Basin (SPA), (2) south of Mare Frigoris, and (3) north of Mare Frigoris. The absorption band positions suggest that the LCPs north of Mare Frigoris and those in SPA are compositionally similar to one another and of ∼Mg50–75, implying that the mafic material excavated by the SPA impact was relatively iron‐rich. Modified Gaussian modeling results suggest that the Apollo basin may have tapped different composition material than is exposed in much of SPA. The LCPs located in the highlands south of Mare Frigoris exhibit absorption bands at short wavelengths consistent with Mg > ∼80. The coincidence of these Mg‐rich LCPs with the thorium measured by Lunar Prospector make them good candidates for KREEP‐related Mg suite pyroxenes.
Key Points
Global survey of exposures of lunar norites
Compositional analysis of freshest exposed norites
High‐Mg norites in Apollo Basin and around Mare Imbrium
We examined the lunar swirls using data from the Moon Mineralogy Mapper (M3). The improved spectral and spatial resolution of M3 over previous spectral imaging data facilitates distinction of subtle ...spectral differences, and provides new information about the nature of these enigmatic features. We characterized spectral features of the swirls, interswirl regions (dark lanes), and surrounding terrain for each of three focus regions: Reiner Gamma, Gerasimovich, and Mare Ingenii. We used Principle Component Analysis to identify spectrally distinct surfaces at each focus region, and characterize the spectral features that distinguish them. We compared spectra from small, recent impact craters with the mature soils into which they penetrated to examine differences in maturation trends on‐ and off‐swirl. Fresh, on‐swirl crater spectra are higher albedo, exhibit a wider range in albedos and have well‐preserved mafic absorption features compared with fresh off‐swirl craters. Albedoand mafic absorptions are still evident in undisturbed, on‐swirl surface soils, suggesting the maturation process is retarded. The spectral continuum is more concave compared with off‐swirl spectra; a result of the limited spectral reddening being mostly constrained to wavelengths less than ∼1500 nm. Off‐swirl spectra show very little reddening or change in continuum shape across the entire M3 spectral range. Off‐swirl spectra are dark, have attenuated absorption features, and the narrow range in off‐swirl albedos suggests off‐swirl regions mature rapidly. Spectral parameter maps depicting the relative OH surface abundance for each of our three swirl focus regions were created using the depth of the hydroxyl absorption feature at 2.82 μm. For each of the studied regions, the 2.82 μm absorption feature is significantly weaker on‐swirl than off‐swirl, indicating the swirls are depleted in OH relative to their surroundings. The spectral characteristics of the swirls and adjacent terrains from all three focus regions support the hypothesis that the magnetic anomalies deflect solar wind ions away from the swirls and onto off‐swirl surfaces. Nanophase iron (npFe0) is largely responsible for the spectral characteristics we attribute to space weathering and maturation, and is created by vaporization/deposition by micrometeorite impacts and sputtering/reduction by solar wind ions. On the swirls, the decreased proton flux slows the spectral effects of space weathering (relative to nonswirl regions) by limiting the npFe0 production mechanism almost exclusively to micrometeoroid impact vaporization/deposition. Immediately adjacent to the swirls, maturation is accelerated by the increased flux of protons deflected from the swirls.
Key Points
The swirls are depleted in OH relative to their surroundings
On‐swirl spectral maturation is retarded and is accelerated off‐swirl
Our results suport deflection of solar wind ions by the magnetic anomalies
The field of religion and science is one of the most exciting and dynamic areas of research today. This Companion brings together an outstanding team of scholars to explore the ways in which science ...intersects with the major religions of the world and religious naturalism. The collection provides an overview of the field and also indicates ways in which it is developing. Its multicultural breadth and scientific rigor on topics that are and will be compelling issues in the first part of the twenty-first century and beyond will be welcomed by students and scholars alike.
A Companion to Japanese History provides an authoritative overview of current debates and approaches within the study of Japan’s history.
Composed of 30 chapters written by an international group of ...scholars
Combines traditional perspectives with the most recent scholarly concerns
Supplements a chronological survey with targeted thematic analyses
Presents stimulating interventions into individual controversies
A statement on ethics from the HEART Group Ector, Hugo; Lancellotti, Patrizio; Roberts, William C. ...
Netherlands heart journal,
05/2008, Volume:
16, Issue:
5
Journal Article, Web Resource
This paper reports on a simulation study of multiple research and development projects that are worked on concurrently and sequentially by more than one research team. The technique employed in the ...modeling and simulation effort was GERT, which was used because of its capability to incorporate the probabilistic outcomes and feedback loops common to R&D projects. The GERT (Graphical Evaluation and Review Technique) includes the modeling of systems in network form and analysis through simulation. It is an important example of technological spin-off from space science research. GERT provides the capability to model and analyze networks of a very general form. Some of the features included in GERT networking are probabilistic branching (stochastic models), network looping (feedback loops), multiple sink nodes (multiple outcomes), multiple node realizations (repeat events), and multiple probability distributions (assigned to activity times). GERT networks are typically analyzed using the GERTS IIIZ simulation package, which provides statistics on project times and cost.
Results of the simulation included statistical data on individual project duration and cost as well as overall network time and cost. These results were employed to provide management with an evaluation of different model configurations, prepare overall time and cost estimates as inputs to contract negotiations and to plan and schedule manpower, equipment and capital. Sensitivity analysts was employed to determine key stages in the R&D process where changes in success-failing probabilities might reduce network time and cost. Implementation experiences validated the model as satisfactory with the exception of several minor problems.
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