Bu araştırmada Covid-19 pandemisinde ebeveynlerin kişilik özellikleri, mükemmeliyetçilik, tükenmişlik ve kaygı düzeyleri arasındaki ilişkinin incelenmesi amaçlanmıştır. Aynı zamanda, ebeveynlerin ...çeşitli demografik özellikleri ve Covid-19 deneyimlerine göre tükenmişlik ve kaygı düzeylerinin farklılaşıp farklılaşmadığı incelenmiştir. Araştırma grubunu 584 (333 anne; 251 baba) yetişkin (Ort. Yaş= 39,93; SS = 6,33) katılımcı oluşturmaktadır. Araştırmada; Kişisel Bilgi Formu, Uluslararası Kişilik Envanteri Kısa Formu, Büyük Üçlü Mükemmeliyetçilik Ölçeği-16, Ebeveyn Tükenmişliği Ölçeği ve Yaygın Anksiyete Bozukluğu-7 Ölçeği kullanılmıştır. Verilerin analizinde Pearson Korelasyon Analizi, Bağımsız Gruplar t-Testi, Tek Yönlü Varyans Analizi, Hiyerarşik Regresyon Analizi teknikleri kullanılmıştır. Araştırma sonucunda; ebeveyn tükenmişliği düzeyinin; cinsiyete, yaşa, pandemi sürecinde çalışma şekline, çocuğun yaşına, çocukla geçirilen süreye ve eşle duygusal ilişki durumuna göre farklılaştığı belirlenmiştir. Yaygın kaygı düzeyinin ise; pandemi sebebiyle yakın vefatı olup olmadığına, pandemi sürecine yönelik kısıtlamalar/düzenlemelerin hayatı nasıl etkilediğine yönelik algıya ve eşle duygusal ilişki durumuna göre farklılaştığı saptanmıştır. Ebeveyn tükenmişliği; duygusal dengesizlik, içe dönüklük, düşmanlık kişilik özellikleri ve mükemmeliyetçilik ile pozitif yönde; dışa dönüklük ve sorumluluk ile negatif yönde ilişkilidir. Yaygın kaygı ise duygusal dengesizlik, içe dönüklük ve mükemmeliyetçilik ile pozitif yönde; dışa dönüklük ve sorumluluk ile negatif yönde ilişkilidir. Ayrıca ebeveyn tükenmişliği ile pozitif yönde ilişkilidir. Araştırmada son olarak; artan duygusal dengesizlik ve içe dönüklük kişilik özelliklerinin ve azalan sorumluluk kişilik özelliğinin ebeveyn tükenmişliği düzeyindeki artışı yordadığı saptanmıştır. Artan duygusal dengesizlik ve öz-eleştirel mükemmeliyetçilik düzeyi ve azalan sorumluluk özelliği ise yaygın kaygıyı yordamaktadır. Araştırma sonuçları ilgili literatür çerçevesinde tartışılmış; ayrıca araştırmanın güçlü yönleri ve sınırlılıklarına değinilmiş, gelecekteki çalışmalara yarar sağlayacak önerilerde bulunulmuştur.
We aimed to identify a rapid, accurate, and accessible biomarker in the early stages of COVID-19 that can determine the prognosis of the disease in cancer patients.
A total number of 241 patients ...with solid cancers who had a COVID-19 diagnosis between March 2020 and February 2022 were included in the study. Factors and ten different markers of inflammation were analyzed by year of diagnosis of COVID-19 and grouped by severity of infection.
Hospitalization, referral to the intensive care unit (ICU), mechanical ventilation, and death were more frequent in 2020 than in 2021 and 2022 (mortality rates, respectively, were 18.8%, 3.8%, and 2.5%). Bilateral lung involvement and chronic lung disease were independent risk factors for severe disease in 2020. In 2021-2022, only bilateral lung involvement was found as an independent risk factor for severe disease. The neutrophil-to-lymphocyte platelet ratio (NLPR) with the highest area under the curve (AUC) value in 2020 had a sensitivity of 71.4% and specificity of 73.3% in detecting severe disease (cut-off > 0.0241, Area Under the Curve (AUC) = 0.842, p <.001). In 2021-2022, the sensitivity of the C-reactive protein-to-lymphocyte ratio (CRP/L) with the highest AUC value was 70.0%, and the specificity was 73.3% (cut-off > 36.7, AUC = 0.829, p = .001).
This is the first study to investigate the distribution and characteristics of cancer patients, with a focus on the years of their COVID-19 diagnosis. Based on the data from our study, bilateral lung involvement is an independent factor for severe disease, and the CRP/L inflammation index appears to be the most reliable prognostic marker.
In studies on the relationship between amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and height velocity in children, CNP has been implicated as an emerging new ...growth marker during childhood. It has been reported that besides its well-studied role in growth, plasma CNP levels are reduced in overweight and/or obese adolescents, suggesting CNP as a potential biomarker in childhood obesity. The primary goal of this study was to test this hypothesis in a Turkish population.
Consent was taken from 317 children ages 0-18 (158 girls, 159 boys) and their parents. All subjects were physically examined; anthropometric measurements were obtained. Body mass index was calculated. During routine blood work, 1 mL extra blood was taken. Plasma NT-proCNP concentration was measured by enzyme-linked immunosorbent assay.
Results confirmed the previously described relationship between plasma NT-proCNP concentration and growth velocity. Plasma NT-proCNP concentration showed a negative correlation with age, weight, and height in children. Gender was not a factor that alters the age-dependent plasma NT-proCNP concentration until puberty.
Unlike previous reports, plasma NT-proCNP concentration of overweight/obese children was not significantly lower than that of children with normal weight in age groups analyzed in a Turkish population. Thus, it is too early to conclude that CNP is a potential biomarker in childhood obesity. Further studies are necessary to address this question.
To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey.
Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric ...neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (≥12 years) groups were compared.
There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease.
Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course.
•This study confirms pediatric MS is a predominantly relapsing-remitting disease.•Brainstem-cerebellar or ADEM-like symptoms, facial paralysis, seizures are frequent.•Onset with sensorial symptoms is less likely compared to later-onset MS.•High rates of vitamin D deficiency and subclinical VEP abnormalities are of note.•First inter-attack interval is longer, disability accumulates faster in early-onset MS.
Neurodevelopmental disorders (NDDs) are clinically and genetically heterogenous; many such disorders are secondary to perturbation in brain development and/or function. The prevalence of NDDs is > ...3%, resulting in significant sociocultural and economic challenges to society. With recent advances in family-based genomics, rare-variant analyses, and further exploration of the Clan Genomics hypothesis, there has been a logarithmic explosion in neurogenetic “disease-associated genes” molecular etiology and biology of NDDs; however, the majority of NDDs remain molecularly undiagnosed. We applied genome-wide screening technologies, including exome sequencing (ES) and whole-genome sequencing (WGS), to identify the molecular etiology of 234 newly enrolled subjects and 20 previously unsolved Turkish NDD families. In 176 of the 234 studied families (75.2%), a plausible and genetically parsimonious molecular etiology was identified. Out of 176 solved families, deleterious variants were identified in 218 distinct genes, further documenting the enormous genetic heterogeneity and diverse perturbations in human biology underlying NDDs. We propose 86 candidate disease-trait-associated genes for an NDD phenotype. Importantly, on the basis of objective and internally established variant prioritization criteria, we identified 51 families (51/176 = 28.9%) with multilocus pathogenic variation (MPV), mostly driven by runs of homozygosity (ROHs) – reflecting genomic segments/haplotypes that are identical-by-descent. Furthermore, with the use of additional bioinformatic tools and expansion of ES to additional family members, we established a molecular diagnosis in 5 out of 20 families (25%) who remained undiagnosed in our previously studied NDD cohort emanating from Turkey.
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