ABSTRACT We present results of a stellar occultation by the Jupiter Trojan asteroid Patroclus and its nearly equal size moon, Menoetius. The geocentric mid-time of the event was 2013 October 21 ...06:43:02 UT. Eleven sites out of 36 successfully recorded an occultation. Seven chords across Patroclus yielded an elliptical limb fit of 124.6 by 98.2 km. There were six chords across Menoetius that yielded an elliptical limb fit of 117.2 by 93.0 km. There were three sites that got chords on both objects. At the time of the occultation we measured a separation of 664.6 km (0.247 arcsec) and a position angle for Menoetius of 265 7 measured eastward from J2000 north. Combining this occultation data with previous light curve data, the axial ratios of both objects are 1.3 : 1.21 : 1, indicative of a mostly oblate ellipsoid with a slight asymmetry in its equatorial projection. The oblate shape is not an equilibrium shape for the current rotation period, but would be if it were rotating with an ∼8 h period. This faster period is consistent with a pre-evolved state of the system with an orbital separation that is 50% smaller. Our best estimate of the system density is 0.88 g cm−3.
Legislating drug prescribing practices Venable, R J
JAMA : the journal of the American Medical Association,
1994-Jul-06, Volume:
272, Issue:
1
Journal Article
The occurrence and visibility of meteoroid impacts on the moon as seen from the Earth were little more than speculation prior to November 1999. The best evidence of present-day impact activity came ...from the seismic experiments left on the Moon during the Apollo era. Past systematic attempts at Earth-based observations to document lunar impacts revealed nothing conclusive. However, during the Leonid storms of 1999 and 2001, lunar impact events were for the first time confirmed by multiple independent observers. A total of 15 meteoritic impact flash events have been verified during these storms, with an additional 12 unconfirmed but likely events awaiting confirmation. Estimates of the mass of these meteoroids range from less than one gram for the faintest flashes to more than 10 kg for the brightest observed flash. The fraction of visible light to total energy produced by these events, a quantity known as luminous efficiency, averages about 0.001 for the established events. The confirmation of lunar meteoritic events on the Moon opens a new avenue in lunar and planetary research, one which could help bridge the gap between atmospheric sampling of the smallest components of meteoroid streams and interplanetary debris to the larger scale objects accessible to ground-based telescopes.
Confirmed observations of meteoroids from the Leonid stream impacting the Moon in 1999 and 2001 have opened up new opportunities in observational and theoretical astronomy. These opportunities could ...help bridge the gap between the ground-based (atmospheric) sampling of the smallest meteoroids and the larger objects observable with ground-based telescopes. The Moon provides a laboratory for the study of hypervelocity impacts, with collision velocities not yet possible in ground-based laboratories. Development of automatic detection software removes the time-intensive activity of laboriously reviewing data for impact event signatures, freeing the observer to engage in other activities. The dynamics of professional-amateur astronomer collaboration have the promise of advancing the study of lunar meteoritic phenomenon considerably. These three factors will assist greatly in the development of a systematic, comprehensive program for monitoring the Moon for meteoroid impacts and determining the physical nature of these impacts.
A case of life-threatening angioedema occurring after 13 months of enalapril therapy is reported. Clinicians should be aware that such severe reactions can occur, even after long-term therapy. ...Patients who take angiotensin-converting enzyme inhibitors should be carefully questioned during each follow-up examination concerning angioedema symptoms.
Ruddy Mars Returns Venable, Roger
Sky and telescope,
11/2011, Volume:
122, Issue:
5
Magazine Article
The mysteries of the Red Planet that entranced the great observers of old are nearly palpable, enlivened rather than buried by the knowledge people have accumulated since their days. Now in Leo, ...Mars' ruddy beacon is slightly brighter than any star in the surrounding constellations. Here, Venable talks about the aphelic apparition of Mars.
Negative allosteric modulation (NAM) of metabotropic glutamate receptor subtype 5 (mGlu₅) represents a therapeutic strategy for the treatment of childhood developmental disorders, such as fragile X ...syndrome and autism. VU0409106 emerged as a lead compound within a biaryl ether series, displaying potent and selective inhibition of mGlu₅. Despite its high clearance and short half-life, VU0409106 demonstrated efficacy in rodent models of anxiety after extravascular administration. However, lack of a consistent correlation in rat between in vitro hepatic clearance and in vivo plasma clearance for the biaryl ether series prompted an investigation into the biotransformation of VU0409106 using hepatic subcellular fractions. An in vitro appraisal in rat, monkey, and human liver S9 fractions indicated that the principal pathway was NADPH-independent oxidation to metabolite M1 (+16 Da). Both raloxifene (aldehyde oxidase inhibitor) and allopurinol (xanthine oxidase inhibitor) attenuated the formation of M1, thus implicating the contribution of both molybdenum hydroxylases in the biotransformation of VU0409106. The use of ¹⁸O-labeled water in the S9 experiments confirmed the hydroxylase mechanism proposed, because ¹⁸O was incorporated into M1 (+18 Da) as well as in a secondary metabolite (M2; +36 Da), the formation of which was exclusively xanthine oxidase-mediated. This unusual dual and sequential hydroxylase metabolism was confirmed in liver S9 and hepatocytes of multiple species and correlated with in vivo data because M1 and M2 were the principal metabolites detected in rats administered VU0409106. An in vitro-in vivo correlation of predicted hepatic and plasma clearance was subsequently established for VU0409106 in rats and nonhuman primates.
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