A series of 4-aminoquinazoline derivatives were designed and synthesized as epidermal growth factor receptor (EGFR) inhibitors in our group. The bioassay results showed all the target compounds ...possessed potential anti-tumor activities against on A549 and H1975 cell lines. The IC50 values of 8.35 (for A549) and 19.18 μM (for H1975) exhibited remarkable inhibitory activity of compound 7d, which were better compared to the positive control Afatinib (IC50 = 10.41 μM for A549, IC50 = 24.96 μM for H1975). In addition, the molecular docking and ADME prediction of compound 7d was carried out. The experimental results show the compound 7d is worth to further research and discuss.
The geomorphic setting of the tectonically active area around Beijing is a result of complex interactions involving Yanshan neotectonic movements and processes of erosion and deposition. The Beijing ...Mountain study area contains the junction of two mountain ranges (the Yanshan Mountains and the Taihang Mountains). Tectonic activity has significantly influenced the drainage system and the geomorphic situation in the area, leading to a high probability of the development of debris flows, which is one of the major abrupt geological disasters in the region. Based on 30-m-resolution ASTER GDEM data, a total of 752 drainage basins were extracted using ArcGIS software. A total of 705 debris flow valleys were visually interpreted from ALOS satellite images and published documents. Seven geomorphic indices were calculated for each basin including the relief amplitude, the hypsometric integral, the stream length gradient, the basin shape indices, the fractal dimension, the asymmetry factor, and the ratio of the valley floor width to the height. These geomorphic indices were divided into five classes and the ratio of the number of the debris flow valleys to the number of the drainage basins for each geomorphic index was computed and analyzed for every class. Average class values of the seven indices were used to derive an index of relative active tectonics (IRAT). The ratio of the number of the debris flow valleys to the number of the drainage basins was computed for every class of IRAT. The degree of probable risk level was then defined from the IRAT classes. Finally, the debris flow hazard was evaluated for each drainage basin based on the combined effect of probable risk level and occurrence frequency of the debris flows. The result showed a good correspondence between IRAT classes and the ratio of the number of the debris flow valleys to the number of the drainage basins. Approximately 65% of the drainage basins with occurred debris flow valleys are at a high risk level, while 43% of the drainage basins without occurred debris flow valleys are at a high risk level. A comparison with results from past studies demonstrated that the accuracy of these findings is greater than 85%, indicating that the basin topography created by rapid tectonic deformations is more favorable for debris flows.
•Geomorphic indices were calculated in Beijing mountain area based on ASTER-DEM.•Ratio between debris-flow valleys and drainage basins for geomorphic indices was computed.•Geomorphic indices were used to yield an index of relative active tectonics (IRAT).•The degrees of the probable risk level were defined from the IRAT classes.•Debris flow hazard was appraised based on probable risk level and occurrence frequency.
With the expansion of its industrial and manufacturing sectors, with the goal of positioning Vietnam as the world’s new production hub, Vietnam is forecast to face a surge in energy demand. Today, ...the main source of energy of Vietnam is fossil fuels, which are not environmentally friendly and are rapidly depleting. The speed of extraction and consumption of fossil fuels is too fast, causing them to become increasingly scarce and gradually depleted. Renewable energy options, such as solar, wind, hydro electrical, and biomass, can be considered as sustainable alternatives to fossil fuels. However, to ensure the effectiveness of renewable energy development initiatives, technological, economic, and environmental must be taken in consideration when choosing a suitable renewable energy resource. In this research, the authors present a multi-criteria decision-making model (MCDM) implementing the grey analytic hierarchy process (G-AHP) method and the weighted aggregates sum product assessment (WASPAS) method for the selection of optimal renewable energy sources for the energy sector of Vietnam. The results of the proposed model have determined that solar energy is the optimal source of renewable energy with a performance score of 0.8822, followed by wind (0.8766), biomass (0.8488), and solid waste energy (0.8135) based on the calculations of the aforementioned methods.
Milk somatic cell count (SCC) refers to the concentration or density of somatic cells in milk, which is a standard to measure the physiological health of dairy cows, milk quality and safety, and also ...an important indicator for the international judgment of invisible mastitis. Therefore, it is of great value to measure the SCC of milk speedy and precisely for monitoring the udder health of dairy cows and ensuring the quality and yield of milk. This paper reviews research progress on SCC in terms of the necessity of SCC detection, acceptable SCC limits in different countries, factors affecting SCC, conventional methods of SCC and the development of integrated state-of-the-art biosensor-based SCC methods. Among them, biosensor-based methods are highlighted for review due to the advantages of low cost, fast detection speed, high sensitivity and applicability to on-site detection, and future development trends are discussed.
•Milk somatic cell count (SCC) is a standard to measure the physiological health, milk quality and safety of dairy cows.•With its low cost, rapid and applicable for on-site detection, biosensors emerge as a new development in milk SCC.•Biosensors for milk SCC based on different detection principles are described and classified.•The current problems, challenges and future development of biosensors in the milk SCC field are summarized and prospected.
The Partners at Care Transitions Measure (PACT-M) is a measure that assesses the quality and safety of care during the transition from hospital to home from the patient's perspective. The aim of this ...study was to examine the psychometric properties of the Chinese version of the PACT-M in Mainland China.
This was a cross-sectional study. A convenience sample of patients was recruited from three tertiary hospitals affiliated with Zhengzhou University, China. A total of 402 participants were interviewed before discharge, and 306 participants were interviewed one month after discharge from hospital to home using the Chinese version of the PACT-M. The statistical methods used in this study include the critical ratio value, item total correlation, test-retest, Cronbach's alpha, confirmatory factor analysis and exploratory factor analysis.
The Chinese version of the PACT-M consists of PACT-M
and PACT-M
, both of which have two dimensions, the number of items in both parts are consistent with the original English language version. The Cronbach's alpha values of the PACT-M
and PACT-M
were 0.802 and 0.741, and the test-retest reliability values were 0.885 and 0.837. The item content validity index and scale content validity index values of the PACT-M
and PACT-M
were all 1.0.
The Chinese version of the PACT-M shows acceptable validity and reliability and can be used to assess the quality and safety of transitional care from hospital to home from the patient's perspective in mainland China.
In this study, copper nanoparticles modified graphitic carbon nitride nanosheets (Cu NPs/g-C
3
N
4
) as a novel peroxidase mimetic were successfully prepared by the calcination of dicyandiamide-Cu
2+
...complex with the assistance of humic acid. The morphology and structure of the product were characterized by X-ray powder diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The prepared Cu NPs/g-C
3
N
4
was found to have highly peroxidase-like activity, which can rapidly catalyze the oxidation of peroxidase substance 3,3′,5,5′-tetramethylbenzidine (TMB) to produce a blue color in the presence of H
2
O
2
. Accordingly, a simple, selective and fast colorimetric method was developed for H
2
O
2
and glucose detection. The prepared Cu NPs/g-C
3
N
4
exhibited low detection limits of 3.2 × 10
−8
M and 3.7 × 10
−7
M for H
2
O
2
and glucose, respectively, due to the excellent peroxidase-like activity of Cu NPs/g-C
3
N
4
originating from the synergistic effect of Cu NPs and g-C
3
N
4
. In this work, we utilized the easily forming complex ability of dicyandiamide and Cu
2+
ions to form a homogeneous precursor solution, and then obtained the CuNPs/g-C
3
N
4
product; such a method may have wide applications in novel composite nanomaterial preparation. The product may have promising applications in medical diagnostics and biotechnology fields.
Cu NPs/g-C
3
N
4
was successfully prepared by the calcination of dicyandiamide-Cu
2+
complex as a peroxidase mimic for sensitive detection of glucose.
The two-dimensional nanomaterials graphene and hexagonal boron nitride (h-BN) have good thermal properties. When the two are combined together to form a planar C-BN hybrid structure or a van der ...Waals heterostructure due to the differences in crystal lattice and the electronic structure between graphene and h-BN, the new material is formed with novel thermal characteristics. We focus on the thermal properties of the two new materials as they change their configuration, size, and number of layers and review these novel characteristics.
Display omitted
Abstract
Background
Amiodarone and esmolol can help to prevent and treat post-cardiac surgery reperfusion ventricular fibrillation. However, the relative efficacies of these two drugs remain unknown. ...The aim of the current trial is to compare the performances of amiodarone and esmolol for preventing reperfusion ventricular fibrillation following open heart surgery.
Methods/design
This is a single-center, prospective, double-blind, controlled clinical trial. A total of 260 patients undergoing heart valve or aortic surgery will be assigned randomly to treatment with prophylactic esmolol (intervention group) or amiodarone (control group). The main outcome is the incidence of reperfusion ventricular fibrillation following aortic opening during extracorporeal circulation. The secondary outcomes are the rate of automatic cardiac resuscitation, energy and frequency of electrical defibrillation, number of electrical defibrillations, and pacemaker use in the two groups of patients. Information on the patients’ general condition and the durations of anesthesia, extracorporeal circulation, aortic occlusion, and operation time will be recorded. We will also compare the heart rate, mean arterial pressure, and central venous pressure between the two groups of patients at induction of anesthesia (T1), start of surgery (T2), start of extracorporeal circulation (T3), aortic block (T4), aortic opening (T5), after opening for 10 (T6), 20 (T7), and 30 min (T8), at cessation of extracorporeal circulation (T9), and at the end of surgery (T10) and compare blood gas analysis results at T1, T5, T9, and T10.
Discussion
This study will determine if prophylactic esmolol is more effective than amiodarone for reducing the incidence of reperfusion ventricular fibrillation in patients undergoing heart valve or aortic surgery.
Trial registration
China Clinical Trials Registry ChiCTR1900026429. Registered on 2019.10.9.
Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver ...disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future.
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