Contemporary emotion regulation research emphasizes intrapersonal processes such as cognitive reappraisal and expressive suppression, but people experiencing affect commonly choose not to go it ...alone. Instead, individuals often turn to others for help in shaping their affective lives. How and under what circumstances does such interpersonal regulation modulate emotional experience? Although scientists have examined allied phenomena such as social sharing, empathy, social support, and prosocial behavior for decades, there have been surprisingly few attempts to integrate these data into a single conceptual framework of interpersonal regulation. Here we propose such a framework. We first map a "space" differentiating classes of interpersonal regulation according to whether an individual uses an interpersonal regulatory episode to alter their own or another person's emotion. We then identify 2 types of processes-response-dependent and response-independent-that could support interpersonal regulation. This framework classifies an array of processes through which interpersonal contact fulfills regulatory goals. More broadly, it organizes diffuse, heretofore independent data on "pieces" of interpersonal regulation, and identifies growth points for this young and exciting research domain.
People often recruit social resources to manage their emotions, a phenomenon known as interpersonal emotion regulation (IER). Despite its importance, IER's psychological structure remains poorly ...understood. We propose that two key dimensions describe IER: (a) individuals' tendency to pursue IER in response to emotional events, and (b) the efficacy with which they perceive IER improves their emotional lives. To probe these dimensions, we developed the Interpersonal Regulation Questionnaire (IRQ), a valid and reliable measure of individual differences in IER. Factor analyses of participants' responses confirmed tendency and efficacy as independent dimensions of IER (Study 1; N = 285), and demonstrated independence between how individuals engage with IER in response to negative, versus positive, emotion. In Study 2 (N = 347), we found that individuals high in IER tendency and efficacy are more emotionally expressive, empathetic, and socially connected. Two subsequent studies highlighted behavioral consequences of IER dimensions: people high in IER tendency sought out others more often following experimentally induced emotion (Study 3; N = 400), and individuals high in IER efficacy benefitted more from social support after real-world emotional events (Study 4; N = 787). Finally, a field study of social networks in freshman dormitories revealed that individuals high in IER tendency and efficacy developed more supportive relationships during the first year of college (Study 5; N = 193). These data (a) identify distinct dimensions underlying IER, (b) demonstrate that these dimensions can be stably measured and separated from related constructs, and (c) reveal their implications for relationships and well-being.
Face masks slow the spread of SARS-CoV-2, but it has been unknown how masks might reshape social interaction. One important possibility is that masks may influence how individuals communicate emotion ...through facial expressions. Here, we clarify to what extent-and how-masks influence facial emotion communication, through drift-diffusion modeling (DDM). Over two independent pre-registered studies, conducted three and 6 months into the COVID-19 pandemic, online participants judged expressions of 6 emotions (anger, disgust, fear, happiness, sadness, surprise) with the lower or upper face "masked" or unmasked. Participants in Study 1 (N = 228) correctly identified expressions above chance with lower face masks. However, they were less likely-and slower-to correctly identify these expressions relative to without masks, and they accumulated evidence for emotion more slowly-via decreased drift rate in DDM. This pattern replicated and intensified 3 months later in Study 2 (N = 264). These findings highlight how effectively individuals still communicate with masks, but also explain why they can experience difficulties communicating when masked. By revealing evidence accumulation as the underlying mechanism, this work suggests that time-sensitive situations may risk miscommunication with masks. This research could inform critical interventions to promote continued mask wearing as needed.
Previous research on adults has shown that a functional polymorphism in the promoter region of the monoamine oxidase A (MAOA) gene moderates the impact of childhood maltreatment on risk for ...developing antisocial behavior. Thus far, attempts to replicate this finding have been mixed. The current study (i) presents new data investigating this finding in a sample of 975 seven-year-old boys, and (ii) evaluates the extant data by conducting a meta-analysis of published findings. We replicated the original finding by showing that the MAOA polymorphism moderates the development of psychopathology after exposure to physical abuse, we extended the finding to childhood closer in time to the maltreatment experience, and we ruled-out the possibility of a spurious finding by accounting for passive and evocative gene-environment correlation. Moreover, meta-analysis demonstrated that across studies, the association between maltreatment and mental health problems is significantly stronger in the group of males with the genotype conferring low vs high MAOA activity. These findings provide the strongest evidence to date suggesting that the MAOA gene influences vulnerability to environmental stress, and that this biological process can be initiated early in life.
Recent evidence documents that cannabis use by young people is a modest statistical risk factor for psychotic symptoms in adulthood, such as hallucinations and delusions, as well as clinically ...significant schizophrenia. The vast majority of cannabis users do not develop psychosis, however, prompting us to hypothesize that some people are genetically vulnerable to the deleterious effects of cannabis.
In a longitudinal study of a representative birth cohort followed to adulthood, we tested why cannabis use is associated with the emergence of psychosis in a minority of users, but not in others.
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene moderated the influence of adolescent cannabis use on developing adult psychosis. Carriers of the COMT valine
158 allele were most likely to exhibit psychotic symptoms and to develop schizophreniform disorder if they used cannabis. Cannabis use had no such adverse influence on individuals with two copies of the methionine allele.
These findings provide evidence of a gene × environment interaction and suggest that a role of some susceptibility genes is to influence vulnerability to environmental pathogens.
Hypertension affects one billion people and is a principal reversible risk factor for cardiovascular disease. Pseudohypoaldosteronism type II (PHAII), a rare Mendelian syndrome featuring ...hypertension, hyperkalaemia and metabolic acidosis, has revealed previously unrecognized physiology orchestrating the balance between renal salt reabsorption and K(+) and H(+) excretion. Here we used exome sequencing to identify mutations in kelch-like 3 (KLHL3) or cullin 3 (CUL3) in PHAII patients from 41 unrelated families. KLHL3 mutations are either recessive or dominant, whereas CUL3 mutations are dominant and predominantly de novo. CUL3 and BTB-domain-containing kelch proteins such as KLHL3 are components of cullin-RING E3 ligase complexes that ubiquitinate substrates bound to kelch propeller domains. Dominant KLHL3 mutations are clustered in short segments within the kelch propeller and BTB domains implicated in substrate and cullin binding, respectively. Diverse CUL3 mutations all result in skipping of exon 9, producing an in-frame deletion. Because dominant KLHL3 and CUL3 mutations both phenocopy recessive loss-of-function KLHL3 mutations, they may abrogate ubiquitination of KLHL3 substrates. Disease features are reversed by thiazide diuretics, which inhibit the Na-Cl cotransporter in the distal nephron of the kidney; KLHL3 and CUL3 are expressed in this location, suggesting a mechanistic link between KLHL3 and CUL3 mutations, increased Na-Cl reabsorption, and disease pathogenesis. These findings demonstrate the utility of exome sequencing in disease gene identification despite the combined complexities of locus heterogeneity, mixed models of transmission and frequent de novo mutation, and establish a fundamental role for KLHL3 and CUL3 in blood pressure, K(+) and pH homeostasis.
Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer's disease and other dementias. However, the extent to which they are ...associated with future risk of dementia in asymptomatic subjects is not clear. In this study, we investigated the relationship between the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score and longitudinal atrophy in middle-aged subjects.
A sample of 167 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 735 days; SD 44 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox.
Annual percentage rates of brain volume and ventricular volume change were greater in those with a high (>6) vs low CAIDE score-absolute brain volume percentage loss 0.17% (CI 0.07 to 0.27) and absolute ventricular enlargement 1.78% (CI 1.14 to 2.92) higher in the at risk group. Atrophy rates did not differ between subjects with and without a parental history of dementia, but were significantly correlated with age. Using linear regression, with covariates of age, sex and education, CAIDE score >6 was the only significant predictor of whole brain atrophy rates (p=0.025) while age (p=0.009), sex (p=0.002) and CAIDE>6 (p=0.017) all predicted ventricular expansion rate.
Our results show that progressive brain atrophy is associated with increased risk of future dementia in asymptomatic middle-aged subjects, two decades before dementia onset.
Children's intellectual development is influenced by both genetic inheritance and environmental experiences. Breastfeeding is one of the earliest such postnatal experiences. Breastfed children attain ...higher IQ scores than children not fed breast milk, presumably because of the fatty acids uniquely available in breast milk. Here we show that the association between breastfeeding and IQ is moderated by a genetic variant in FADS2, a gene involved in the genetic control of fatty acid pathways. We confirmed this gene-environment interaction in two birth cohorts, and we ruled out alternative explanations of the finding involving gene-exposure correlation, intrauterine growth, social class, and maternal cognitive ability, as well as maternal genotype effects on breastfeeding and breast milk. The finding shows that environmental exposures can be used to uncover novel candidate genes in complex phenotypes. It also shows that genes may work via the environment to shape the IQ, helping to close the nature versus nurture debate.
DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic ...variation and have been associated with disease susceptibility. The degree to which changes in loci-specific DNA methylation are under the influence of heritable and environmental factors is largely unknown. In this study, we quantitatively measured DNA methylation across the promoter regions of the dopamine receptor 4 gene (DRD4), the serotonin transporter gene (SLC6A4/SERT) and the X-linked monoamine oxidase A gene (MAOA) using DNA sampled at both ages 5 and 10 years in 46 MZ twin-pairs and 45 DZ twin-pairs (total n=182). Our data suggest that DNA methylation differences are apparent already in early childhood, even between genetically identical individuals, and that individual differences in methylation are not stable over time. Our longitudinal-developmental study suggests that environmental influences are important factors accounting for interindividual DNA methylation differences, and that these influences differ across the genome. The observation of dynamic changes in DNA methylation over time highlights the importance of longitudinal research designs for epigenetic research.
Abstract
Gneiss domes are an integral element of many orogenic belts and commonly provide tectonic windows into deep crustal levels. Gneiss domes in the New England segment of the Appalachian orogen ...have been classically associated with diapirism and fold interference, but alternative models involving ductile flow have been proposed. We evaluate these models in the Gneiss Dome belt of western New England with U‐Th‐Pb monazite, xenotime, zircon, and titanite petrochronology and major and trace element thermobarometry. These data constrain distinct pressure–temperature–time (P‐T‐t) paths for each unit in the gneiss dome belt tectono‐stratigraphy. The structurally lowest units, Laurentia‐derived migmatitic gneisses of the Waterbury dome, document two stages of metamorphism (455–435 and 400–370 Ma) with peak Acadian metamorphic conditions of ~1.0–1.2 GPa at 750–780°C at 391 ± 7 to 386 ± 4 Ma. The next structurally higher unit, the Gondwana‐derived Taine Mountain Formation, records Taconic (peak conditions: 0.6 GPa, 600°C at 441 ± 4 Ma) and Acadian (peak: 0.8–1.0 GPa, 650°C at 377 ± 4 Ma) metamorphism. The overlying Collinsville Formation yielded a 473 ± 5 Ma crystallization age and evidence for metamorphic conditions of 650°C at 436 ± 4 Ma and 1.2–1.0 GPa, 750–775°C at 397 ± 4 to 385 ± 6 Ma. The structurally higher Sweetheart Mountain Member of the Collinsville Formation yielded only Acadian zircon, monazite, and xenotime dates and evidence for high‐pressure granulite facies metamorphism (1.8 GPa, 815°C) at circa 380–375 Ma. Cover rocks of the dome‐mantling The Straits Schist records peak conditions of ~1 GPa, 700°C at 386 ± 6 to 380 ± 4 Ma. Garnet breakdown to monazite and/or xenotime occurred in all units at circa 375–360 and 345–330 Ma. Peak Acadian metamorphic pressures increase systematically from the structurally lowest to highest units (from 1.0 to 1.8 GPa). This inverted metamorphic sequence is incompatible with the diapiric and fold interference models, which predict the highest pressures at the structurally lowest levels. Based upon P‐T‐t and structural data, we prefer a model involving, first, circa 380 Ma thrust stacking followed by syn‐collisional orogen parallel extension, ductile flow, and rise of the domes between 380 and 365 Ma. Garnet breakdown at circa 345–330 Ma is interpreted to reflect further exhumation during collapse of the Acadian orogenic plateau. These results highlight the power of integrating petrologic constraints with paired geochemical and geochronologic data from multiple chronometers to test structural and tectonic models and show that syn‐convergent orogen parallel ductile flow dramatically modified earlier accretion‐related structures in New England. Further, the Gneiss Dome belt documents gneiss dome development in a syn‐collisional, thick crust setting, providing an ancient example of middle to lower crustal processes that may be occurring today in the modern Himalaya and Pamir Range.
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