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  • A large, refractory nosocom... A large, refractory nosocomial outbreak of Klebsiella pneumoniae carbapenemase-producing Escherichia coli demonstrates carbapenemase gene outbreaks involving sink sites require novel approaches to infection control
    Decraene, V; Phan, H T T; George, R ... Antimicrobial agents and chemotherapy, 12/2018, Volume: 62, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Carbapenem-resistant (CRE) represent a health threat, but effective control interventions remain unclear. Hospital wastewater sites are increasingly being highlighted as important potential ...
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  • Regulation of Toll-like rec... Regulation of Toll-like receptors in human monocytes and dendritic cells
    Visintin, A; Mazzoni, A; Spitzer, J H ... The Journal of immunology (1950), 2001-Jan-01, Volume: 166, Issue: 1
    Journal Article
    Peer reviewed
    Open access

    A number of pathogens induce immature dendritic cells (iDC) to migrate to lymphoid organs where, as mature DC (mDC), they serve as efficient APC. We hypothesized that pathogen recognition by iDC is ...
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  • Predicting antimicrobial su... Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data
    Stoesser, N; Batty, E M; Eyre, D W ... Journal of antimicrobial chemotherapy, 10/2013, Volume: 68, Issue: 10
    Journal Article
    Peer reviewed
    Open access

    Whole-genome sequencing potentially represents a single, rapid and cost-effective approach to defining resistance mechanisms and predicting phenotype, and strain type, for both clinical and ...
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  • Evidence for an accessory p... Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses
    Wyllie, D H; Kiss-Toth, E; Visintin, A ... The Journal of immunology (1950), 2000-Dec-15, Volume: 165, Issue: 12
    Journal Article
    Peer reviewed
    Open access

    Members of the Toll-like receptor (TLR) family are components of the mammalian anti-microbial response, signaling with a domain closely related to that of IL-1 receptors. In this report the ...
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  • Increasing incidence of Esc... Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic database study in Oxfordshire 1999-2011
    SCHLACKOW, Iryna; STOESSER, Nicole; WALKER, A. Sarah ... Journal of antimicrobial chemotherapy, 06/2012, Volume: 67, Issue: 6
    Journal Article
    Peer reviewed

    To investigate trends in Escherichia coli resistance, bacteraemia rates and post-bacteraemia outcomes over time. Trends in E. coli bacteraemia incidence were monitored from January 1999 to June 2011 ...
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  • Relation between lymphopeni... Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    Wyllie, D H; Bowler, I C J W; Peto, T E A Journal of clinical pathology, 09/2004, Volume: 57, Issue: 9
    Journal Article
    Peer reviewed
    Open access

    Aims: To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia. ...
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  • Saliva for Detection of SAR... Saliva for Detection of SARS-CoV-2
    Markewitz, Robert D H; Wandinger, Klaus-Peter; Junker, Ralf New England journal of medicine/˜The œNew England journal of medicine, 03/2021, Volume: 384, Issue: 9
    Journal Article
    Peer reviewed
    Open access
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  • Single nucleotide polymorph... Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context
    Chen, Hongmin; Wilkins, Leon M.; Aziz, Nazneen ... Human molecular genetics, 02/2006, Volume: 15, Issue: 4
    Journal Article
    Peer reviewed
    Open access

    We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide polymorphisms (SNPs) within a gene promoter region interleukin-1-beta (IL1B) ...
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  • Hospital exposure in a UK p... Hospital exposure in a UK population, and its association with bacteraemia
    Wyllie, D.H; Walker, A.S; Peto, T.E.A ... The Journal of hospital infection, 12/2007, Volume: 67, Issue: 4
    Journal Article
    Peer reviewed

    Summary Despite the importance of healthcare-associated infection, few studies have quantified the association between severe infection and hospital exposure in UK populations. Our aim was to ...
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  • A Lipopolysaccharide-Defici... A Lipopolysaccharide-Deficient Mutant of Neisseria meningitidis Elicits Attenuated Cytokine Release by Human Macrophages and Signals via Toll-like Receptor (TLR) 2 but Not via TLR4/MD2
    Pridmore, Alison C.; Wyllie, David H.; Abdillahi, Fatumo ... The Journal of infectious diseases, 01/2001, Volume: 183, Issue: 1
    Journal Article
    Peer reviewed

    Meningococcal disease severity correlates with circulating concentrations of lipopolysaccharide (LPS) and proinflammatory cytokines. Disruption of the lpxA gene of Neisseria meningitidis generated a ...
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