Humans can naturally and effectively find salient regions in complex scenes. Motivated by this observation, attention mechanisms were introduced into computer vision with the aim of imitating this ...aspect of the human visual system. Such an attention mechanism can be regarded as a dynamic weight adjustment process based on features of the input image. Attention mechanisms have achieved great success in many visual tasks, including image classification, object detection, semantic segmentation, video understanding, image generation, 3D vision, multimodal tasks, and self-supervised learning. In this survey, we provide a comprehensive review of various attention mechanisms in computer vision and categorize them according to approach, such as channel attention, spatial attention, temporal attention, and branch attention; a related repository
https://github.com/MenghaoGuo/Awesome-Vision-Attentions
is dedicated to collecting related work. We also suggest future directions for attention mechanism research.
The current work is a study of electricity, hydrogen, and freshwater polygeneration system fueled by biomass fuel. Accordingly, innovative integration of a Rankine cycle, a multi-effect desalination, ...and a solid oxide electrolyzer cell has been considered utilizing a syngas production biomass combustion chamber. The waste heat and a part of the output electricity of the Rankine cycle have been employed to launch the desalination and electrolyzer units, respectively. The suggested polygeneration is analyzed from the thermodynamic and exergoeconomic viewpoints through developing a code in engineering equation solver software and a multi-criteria optimization via MATLAB software. Hence, the NSGA-II optimization method and decision-making TOPSIS technique have been implemented. The parametric study has been conducted based on the effect of biomass fuel mass flow rate, turbine inlet pressure, combustion chamber outlet temperature, and pinch point temperature difference of the steam generator on the thermodynamic and exergoeconomic variables of the whole system. Considering the total exergy destruction rate, exergy efficiency, and total unit exergy cost of products as objective functions, the suggested system achieved the optimum values of 17.64%, 7658.5 kW, and 26 $/GJ corresponding for these variables.
•An integrated cycle for power, freshwater, and hydrogen is devised.•Comprehensive energy, exergy, exergoeconomic analyses are performed.•Multi-objective optimization is developed for the optimization process.•For the optimization scenario, 17.16%, 7658.5 kW, and 26 $/GJ for exergy efficiency, exergy destruction, and unit exergy cost were obtained.
Xpert Xpress Flu/RSV is a fast and automated real-time nucleic acid amplification tool for detecting influenza virus and respiratory syncytial virus (RSV). The aim of this study was to verify the ...accuracy of Xpert Xpress Flu/RSV for detecting influenza virus and RSV. PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched up to October 2020. The quality of the original research was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 guidelines. Meta-DiSc 1.4 software was used to analyze the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and summary receiver operating characteristic curve. Deek’s funnel plot asymmetry test was used to evaluate the publication bias using the Stata 12.0 software. Ten studies with 25 fourfold tables were included in the analysis. The sensitivity of Xpert Xpress Flu/RSV for detecting influenza A, influenza B, and RSV were 0.97, 0.98, and 0.96, respectively, and the specificities were 0.97, 1.00, and 1.00, respectively. Compared with other common clinical real-time reverse transcription-polymerase chain reaction (RT-PCR), Xpert Xpress Flu/RSV is a valuable tool for diagnosing influenza virus and RSV with high sensitivity and specificity.
Abstract
Background
Photoaging is a degenerative biological process that affects the quality of life. It is caused by environmental factors including ultraviolet radiation (UVR), deep skin burns, ...smoking, active oxygen, chemical substances, and trauma. Among them, UVR plays a vital role in the aging process.
Aim
With the continuous development of modern medicine, clinical researchers have investigated novel approaches to treat aging. In particular, mesenchymal stem cells (MSCs), non‐coding RNAs are involved in various physiological processes have broad clinical application as they have the advantages of convenient samples, abundant sources, and avoidable ethical issues.
Methods
This article reviews research progress on five types of stem cell, exosomes, non‐coding RNA in the context of photoaging treatment: adipose‐derived stem cell, human umbilical cord MSCs, epidermal progenitor cells, keratinocyte stem cells, and hair follicle stem cells (HFSCs). It also includes stem cell related exosomes and their non‐coding RNA research.
Results
The results have clinical guiding significance for prevention and control of the onset and development of photoaging. It is found that stem cells secrete cytokines, cell growth factors, non‐coding RNA, exosomes and proteins to repair aging skin tissues and achieve skin rejuvenation. In particular, stem cell exosomes and non‐coding RNA are found to have significant research potential, as they possess the benefits of their source cells without the disadvantages which include immune rejection and granuloma formation.
•Morphologies of oxide particles in two FeCrAl-ODS steels with Zr and/or Ti were studied.•Crystal & interface structures of 88 oxides in 3.3Al–0.5Zr ODS steel were studied.•Crystal & interface ...structures of 171 oxides in 3.7Al–0.1Ti–0.6Zr ODS steel were studied.•Proportions of various types of oxides were determined according to HRTEM results.•Crystallographic orientation correlations of the oxides & matrix were determined.•Formation & strengthening mechanisms of oxides in both ODS steels were discussed.
FeCrAl oxide dispersion strengthened (ODS) steel is one of the most promising candidate cladding materials for Generation IV nuclear reactors due to its superior high temperature strength and excellent resistance to creep, corrosion and irradiation. The morphologies of matrix grains and oxides, the crystal and metal/oxide interface structures of nanoparticles in two FeCrAl ODS steels, i.e., 3.3Al–0.5Zr (Fe–15Cr–2W–3.3Al–0.5Zr–0.35Y2O3) and 3.7Al–0.1Ti–0.6Zr (Fe–15Cr–2W–3.7Al–0.1Ti–0.6Zr–0.35Y2O3), were studied by transmission electron microscopy (TEM), scanning transmission electron microscopy (STEM) and high resolution transmission electron microscopy (HRTEM). The average matrix grain sizes of 3.3Al–0.5Zr ODS steel and 3.7Al–0.1Ti–0.6Zr ODS steel are 1.01 and 0.97 μm, respectively. The dispersion morphology of oxides in 3.7Al–0.1Ti–0.6Zr ODS steel is much better, relative to that of 3.3Al–0.5Zr ODS steel. Crystal & interface structures of 88 and 171 oxides in 3.3Al–0.5Zr ODS steel and 3.7Al–0.1Ti–0.6Zr ODS steel were characterized, respectively. The proportions of Y–Zr–O, Y–Al–O, Y–Cr–O, ZrO2 and Y2O3 in 3.3Al–0.5Zr ODS steel are 77.2%, 9.1%, 2.3%, 2.3% and 2.3%, respectively and, however, the proportions of Y–Zr–O, Y–Ti–O, Y–Al–O and ZrO2 in 3.7Al–0.1Ti–0.6Zr ODS steel are 86.5%, 8.3%, 3.5% and 1.7%, respectively. The much better dispersion morphology of oxides in 3.7Al–0.1Ti–0.6Zr ODS steel, relative to that of 3.3Al–0.5Zr ODS steel, is due to the much higher proportion of Y–Zr–O, the considerably lower proportion of Y–Al–O and the fairly high number fraction of Y–Ti–O. The mechanisms of the formation and polymorphic transition of various kinds of oxides and, moreover, the strengthening mechanisms in both ODS steels were discussed.
The objective of this study is to observe the effect of high selenium on the antioxidant and immune functions of growing goats based on transcriptome sequencing. Eighteen goats were randomly divided ...into three groups: (1) the control (CON) group was fed a basal diet, and (2) the treatment 1 group (LS) and treatment 2 group (HS) were fed a basal diet with 2.4 and 4.8 mg/kg selenium-yeast (SY), respectively. The results indicate that HS treatment significantly (p < 0.05) increased the apparent digestibility of either extract and significantly increased (p < 0.05) total antioxidant capacity, whereas it significantly (p < 0.05) decreased plasma aspartate aminotransferase and malondialdehyde relative to the control group. The LS treatment had significantly (p < 0.05) increased glutathione S-transferase and catalase compared to CON. A total of 532 differentially expressed genes (DEGs) between the CON and HS were obtained using transcriptome sequencing. Kyoto Encyclopedia of Genes and Genomes analysis identified upregulated (p < 0.05) DEGs mainly related to vascular smooth muscle contraction, alpha-linolenic acid metabolism, biosynthesis of unsaturated fatty acids, the VEGF signalling pathway, and proteoglycans in cancer; downregulated (p < 0.05) DEGs mainly related to the NOD-like receptor signalling pathway, influenza A, cytokine-cytokine receptor interaction, haematopoietic cell lineage, and African trypanosomiasis. Ontology analyses of the top genes show that the identified DEGs are mainly involved in the regulation of granulocyte macrophage colony-stimulating factor production for biological processes, the external side of the plasma membrane for cellular components, and carbohydrate derivative binding for molecular functions. Seven genes are considered potential candidate genes for regulating antioxidant activity, including selenoprotein W, 1, glutathione peroxidase 1, glutathione S-transferase A1, tumour necrosis factor, tumour necrosis factor superfamily member 10, tumour necrosis factor superfamily member 8, and tumour necrosis factor superfamily member 13b. The experimental observations indicate that dietary supplementation with 4.8 mg/kg SY can enhance antioxidant and immune functions by improving muscle immunity, reducing the concentrations of inflammatory molecules, and modulating antioxidant and inflammatory signalling pathways in growing goats.
A new hierarchy: A supramolecular template strategy is used to synthesize hierarchical micro‐ and mesoporous metal–organic frameworks. The mesopore walls are constructed from a microporous framework ...(see picture). The porosity can be tuned by using different templates at various molar ratios.
Exposure to cadmium (Cd), a toxic metal, is epidemiologically linked to nonalcoholic steatohepatitis (NASH) in humans. However, the role of Cd in NASH remains to be fully elucidated. This study ...employed a novel murine NASH model to investigate the effects of chronic low-dose Cd on hepatic pathology and its underlying mechanisms. NASH is characterized by lipid accumulation, extensive cell death, and persistent inflammation in the liver. We found that treatment with Cd in drinking water (10 mg/L) for 6 or 12 weeks significantly boosted hepatic fat deposition, increased hepatocyte destruction, and amplified inflammatory responses in mice, confirming that low-dose Cd can facilitate NASH development in vivo. Mechanistically, chronic Cd exposure reshaped the hepatic transcriptional landscape, with PPAR-mediated fatty acid metabolic pathways being the most significantly altered. In particular, Cd repressed fatty acid desaturation, leading to the accumulation of saturated fatty acids whose lipotoxicity exacerbated cell death and, consequently, inflammatory activation. In summary, we validated the causal effects of chronic low-dose Cd on NASH in vivo and identified the fatty acid desaturation program as a novel target for Cd to instigate hepatopathological alterations.
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•Low-dose cadmium (Cd) facilitates non-alcoholic steatohepatitis (NASH).•Cd suppresses fatty acid desaturation, leading to buildup of saturated lipids.•Lipotoxicity by saturated lipids synergizes Cd to cause extensive liver damages.•Extensive hepatic cell deaths feedforward to persistent inflammatory responses.•Hepatic lipotoxicity and inflammation culminate in Cd-induced NASH.
Background
Detection of hepatitis B virus (HBV) is vital for the diagnosis of hepatitis B infection. A novel test loop‐mediated isothermal amplification (LAMP) has been successfully applied to detect ...various pathogens. However, the accuracy of LAMP in diagnosing HBV remains unclear. Therefore, in the present study, the accuracy of LAMP for HBV detection was evaluated systematically.
Methods
Embase, Cochrane Library, and PubMed databases were searched for studies using LAMP to detect HBV. Then, two researchers extracted data and assessed the quality of literature using the QUADAS‐2 tool independently. I2 statistic and chi‐square test were analyzed to investigate the heterogeneity, and Deek's funnel plot assessed the publication bias. The pooled sensitivity (SEN), specificity (SPE), positive LR (PLR), negative LR (NLR), diagnostic odds ratio (DOR), and 95% confidence intervals were displayed in forest plots. We calculated the area under the curve (AUC) to assess the overall efficiency of LAMP for HBV detection.
Results
A total of nine studies with 1298 samples were finally included in this evaluation. The pooled sensitivity and specificity of HBV detection were 0.91 (95% CI: 0.89 ~ 0.92) and 0.97 (95% CI: 0.94 ~ 0.99), respectively. The PLR, NLR, and DOR were 16.93 (95% CI: 6.15 ~ 46.55), 0.08 (95% CI: 0.05 ~ 0.14), and 397.57 (95% CI: 145.41 ~ 1087.07). Besides, the AUC was 0.9872, and Deek's plot suggested that there existed publication bias in the studies.
Conclusion
Compared with PCR, LAMP is a simple, rapid, and effective assay to diagnose HBV. However, additional evidence is essential to confirm that LAMP can replace other methods in diagnosing HBV infection.
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