•This study explores antecedents of loyalty to branded applications (app) and brands.•The lens of affordance and service-dominant logic are used to build the research model.•Five app affordances are ...identified as antecedents of value-in-use (VIU).•VIU directly influences both app continuance intention and brand loyalty.•VIU also influences loyalty through brand competence and brand warmth.
The rise of mobile apps is compelling ambitious companies to rush to market their own branded apps in hopes of building customers’ brand loyalty. By applying service-dominant logic, the lens of affordance, and two brand perceptions (brand competence and brand warmth), this study explores critical determinants of app continuance intention and brand loyalty among app users. Five affordances of branded apps are linked to value-in-use, which contributes both directly and indirectly to the two loyalty-related outcomes, through either brand competence or brand warmth. Data collected from 634 app users support all proposed hypotheses. Theoretical and practical implications are discussed.
Palladium diselenide (PdSe2), a thus far scarcely studied group‐10 transition metal dichalcogenide has exhibited promising potential in future optoelectronic and electronic devices due to unique ...structures and electrical properties. Here, the controllable synthesis of wafer‐scale and homogeneous 2D PdSe2 film is reported by a simple selenization approach. By choosing different thickness of precursor Pd layer, 2D PdSe2 with thickness of 1.2–20 nm can be readily synthesized. Interestingly, with the increase in thickness, obvious redshift in wavenumber is revealed by Raman spectroscopy. Moreover, in accordance with density functional theory (DFT) calculation, optical absorption and ultraviolet photoemission spectroscopy (UPS) analyses confirm that the PdSe2 exhibits an evolution from a semiconductor (monolayer) to semimetal (bulk). Further combination of the PdSe2 layer with Si leads to a highly sensitive, fast, and broadband photodetector with a high responsivity (300.2 mA W−1) and specific detectivity (≈1013 Jones). By decorating the device with black phosphorus quantum dots, the device performance can be further optimized. These results suggest the as‐selenized PdSe2 is a promising material for optoelectronic application.
This study reports on the wafer‐area synthesis of a high‐quality 2D palladium diselenide (PdSe2) layer through a simple selenization method. Both experimental analysis and theoretical simulation reveal that the PdSe2 film exhibits a gradual transition from a semiconductor (monolayer) to semimetal (bulk). Further combination of PdSe2 with Si leads to a fast and sensitive broadband photodiode, with a high responsivity and specific detectivity.
Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report ...that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H
O
and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.
Characterizing the long-term nanometer-scale interactions between lysosomes and mitochondria in live cells is essential for understanding their functions but remains challenging due to limitations of ...the existing fluorescent probes. Here, we develop cell-permeable organic fluorescent probes for lysosomes with excellent specificity and high photostability. We also use an existing Atto 647N dye with high brightness and excellent photostability to achieve specific labeling of mitochondria in live cells. Using these probes, we obtain dual-color structured illumination microscopy (SIM) images of dynamic physical lysosome-mitochondrion interactions in live cells at an ~90-nm resolution over a long time course of ~13 min. We successfully record the consecutive dynamic processes of lysosomal fusion and fission, as well as four types of physical lysosome-mitochondrion interactions by super-resolution imaging. Our probes provide an avenue for understanding the functions and the dynamic interplay of lysosomes and mitochondria in live cells.
Attention has arguably become one of the most important concepts in the deep learning field. It is inspired by the biological systems of humans that tend to focus on the distinctive parts when ...processing large amounts of information. With the development of deep neural networks, attention mechanism has been widely used in diverse application domains. This paper aims to give an overview of the state-of-the-art attention models proposed in recent years. Toward a better general understanding of attention mechanisms, we define a unified model that is suitable for most attention structures. Each step of the attention mechanism implemented in the model is described in detail. Furthermore, we classify existing attention models according to four criteria: the softness of attention, forms of input feature, input representation, and output representation. Besides, we summarize network architectures used in conjunction with the attention mechanism and describe some typical applications of attention mechanism. Finally, we discuss the interpretability that attention brings to deep learning and present its potential future trends.
Androgen-deprivation therapy (ADT) has been the backbone of treatment for metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with ADT plus docetaxel would result in ...longer overall survival than that with ADT alone.
We assigned men with metastatic, hormone-sensitive prostate cancer to receive either ADT plus docetaxel (at a dose of 75 mg per square meter of body-surface area every 3 weeks for six cycles) or ADT alone. The primary objective was to test the hypothesis that the median overall survival would be 33.3% longer among patients receiving docetaxel added to ADT early during therapy than among patients receiving ADT alone.
A total of 790 patients (median age, 63 years) underwent randomization. After a median follow-up of 28.9 months, the median overall survival was 13.6 months longer with ADT plus docetaxel (combination therapy) than with ADT alone (57.6 months vs. 44.0 months; hazard ratio for death in the combination group, 0.61; 95% confidence interval CI, 0.47 to 0.80; P<0.001). The median time to biochemical, symptomatic, or radiographic progression was 20.2 months in the combination group, as compared with 11.7 months in the ADT-alone group (hazard ratio, 0.61; 95% CI, 0.51 to 0.72; P<0.001). The rate of a prostate-specific antigen level of less than 0.2 ng per milliliter at 12 months was 27.7% in the combination group versus 16.8% in the ADT-alone group (P<0.001). In the combination group, the rate of grade 3 or 4 febrile neutropenia was 6.2%, the rate of grade 3 or 4 infection with neutropenia was 2.3%, and the rate of grade 3 sensory neuropathy and of grade 3 motor neuropathy was 0.5%.
Six cycles of docetaxel at the beginning of ADT for metastatic prostate cancer resulted in significantly longer overall survival than that with ADT alone. (Funded by the National Cancer Institute and others; ClinicalTrials.gov number, NCT00309985.).
Understanding the relationship between social interaction patterns and cognitive engagement levels has critical implications on collaborative learning theory, pedagogy, and technology. This study ...used a multi‐method approach to examine the relationship between students' social participatory roles and cognitive engagement levels within asynchronous online discussions. Results showed that students' social participatory role was a critical indicator of cognitive engagement level. Socially active students made more cognitive contributions to knowledge inquiry and knowledge construction. But there were exceptions: after taking leadership roles (i.e., discussion designers and facilitators), some students moved from peripheral participation to active participation. Second, there was a progressive development process: individual students' deep‐level knowledge inquiry could trigger peer interaction, which could further advance group knowledge construction. Third, students had a tendency to keeping social‐cognitive engagement patterns throughout discussions. Based on the result, this study proposed implications for collaborative learning theory, pedagogy support, and tool development.
We study the Page curve for eternal Garfinkle–Horowitz–Strominger dilaton black holes in four dimensional asymptotically flat spacetime by using the island paradigm. The results demonstrate that ...without the island, the entanglement entropy of Hawking radiation is proportional to time and becomes divergent at late times. While taking account of the existence of the island outside the event horizon, the entanglement entropy stops growing at late times and eventually reaches a saturation value. This value is twice of the Bekenstein–Hawking entropy and consistent with the finiteness of the von Neumann entropy of eternal black holes. Moreover, we discuss the impact of the stringy coefficient
n
and charge
Q
on the Page time and the scrambling time respectively. For the non-extremal case, the influence of the coefficient
n
on them is small compared to the influence of the charge
Q
. However, for the extremal case, the Page time and the scrambling time become divergent or near vanishing. This implies the island paradigm needs further investigation.
Designing transparent flexible electronics with multi‐biological neuronal functions and superior flexibility is a key step to establish wearable artificial intelligence equipment. Here, a flexible ...ionic gel‐gated VO2 Mott transistor is developed to simulate the functions of the biological synapse. Short‐term and long‐term plasticity of the synapse are realized by the volatile electrostatic carrier accumulation and nonvolatile proton‐doping modulation, respectively. With the achievement of multi‐essential synaptic functions, an important sensory neuron, nociceptor, is perfectly simulated in our synaptic transistors with all key characteristics of threshold, relaxation, and sensitization. More importantly, this synaptic transistor exhibits high tolerance to the bending deformation, and the cycle‐to‐cycle variations of multi‐conductance states in potentiation and depression properties are maintained within 4%. This superior stability further indicates that our flexible device is suitable for neuromorphic computing. Simulation results demonstrate that high recognition accuracy of handwritten digits (>95%) can be achieved in a convolution neural network built from these synaptic transistors. The transparent and flexible Mott transistor based on electrically‐controlled VO2 metal‐insulator transition is believed to open up alternative approaches to developing highly stable synapses for future flexible neuromorphic systems.
A flexible Mott synaptic transistor is developed to simulate the functions of a biological synapse. A sensory neuron, nociceptor, is simulated based on multi‐essential synaptic functions. The high recognition accuracy of handwritten digits (>95%) can be achieved, demonstrating that the flexible ionic gel‐gated VO2 Mott transistor opens up alternative approaches to developing highly stable synapses for future flexible neuromorphic systems.
Ibis study adds to the growing research exploring the consequences of knowledge hiding in organizations. Drawing from the social exchange theory and the norm of reciprocity, this paper examines the ...direct and indirect—via distrust in supervisor—relationships between supervisor knowledge hiding (SKH) and supervisee organizational citizenship behavior directed at the supervisor (OCB-S) in the context of the Middle East. Using a supervisor-supervisee dyadic design, two-source data were obtained from 317 employees (local and foreign) of 41 Saudi firms. The findings suggest that supervisees' distrust in their supervisors mediates the significant and negative relationship between SKH and supervisees' OCB-S. Furthermore, the significant and positive relationship between SKH and distrust in supervisor is more pronounced for foreign workers than for local workers. This study provides empirical support and a better understanding of the existence and consequences of SKH for local and foreign workers and also discusses the theoretical and practical implications of the findings.
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