In this study, two phenol compounds, magnolol and honokiol, were extracted from
and identified by LC-MS,
H- and
C-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic ...fungi, including
(Fr.) Keissl,
(Link) Thom,
f.sp. solani,
J. Sheld,
Schltdl.,
Miyabe & G. Yamada, and
J.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and honokiol. The results showed that they inhibited the growth of
in a dose-dependent manner. Moreover, magnolol and honokiol treatment resulted in distorted mycelia and increased the cell membrane permeability of
, as determined by conductivity measurements. These results suggest that magnolol and honokiol are potential antifungal agents for application against plant fungal diseases.
The pursuit of synthetic receptors with high binding affinities has long been a central focus in supramolecular chemistry, driven by their significant practical relevance in various fields. Despite ...the numerous synthetic receptors that have been developed, most exhibit binding affinities in the micromolar range or lower. Only a few exceptional receptors achieve binding affinities exceeding 109 M−1, and their substrate scopes remain rather limited. In this context, we introduce SC5A, a conjugated corral‐shaped macrocycle functionalized with ten sulfate groups. Owing to its deep one‐dimensional confined hydrophobic cavity and multiple sulfate groups, SC5A displays an extraordinarily high binding strength of up to 1011 M−1 towards several size‐matched, rod‐shaped organic dications in water. Besides, its conformation exhibits good adaptability, allowing it to encapsulate a wide range of other guests with diverse molecular sizes, shapes, and functionalities, exhibiting relatively strong affinities (Ka=106–108 M−1). Additionally, we've explored the preliminary application of SC5A in alleviating blood coagulation induced by hexadimethrine bromide in vitro and in vivo. Therefore, the combination of ultrahigh binding affinities (towards complementary guests) and adaptive recognition capability (towards a wide range of functional guests) of SC5A positions it as exceptionally valuable for numerous practical applications.
A new water‐soluble corral‐shaped conjugated host bearing ten sulfate groups at its two rims—namely, SC5A—was synthesized. SC5A not only exhibited ultrahigh binding affinities (up to 1011 M−1) towards a series of rod‐shaped substrates, but also effectively bound (Ka=106–108 M−1) a wide range of functional substrates. Additionally, the application of SC5A in alleviating blood coagulation induced by hexadimethrine bromide was explored.
The precise recognition and sensing of steroids, a type of vital biomolecules, hold immense practical value across various domains. In this study, we introduced corral4BINOLs (C4BINOLs), a pair of ...enantiomeric conjugated deep‐cavity hosts, as novel synthetic receptors for binding steroids. Due to the strong hydrophobic effect of their deep nonpolar, chiral cavities, the two enantiomers of C4BINOLs demonstrated exceptionally high recognition affinities (up to 1012 M−1) for 16 important steroidal compounds as well as good enantioselectiviy (up to 15.5) in aqueous solutions, establishing them as the most potent known steroid receptors. Harnessing their ultrahigh affinity, remarkable enantioselectivity, and fluorescence emission properties, the two C4BINOL enantiomers were employed to compose a fluorescent sensor array which achieved discrimination and sensing of 16 structurally similar steroids at low concentrations.
A pair of enantiomeric macrocycles, RRRR‐ and SSSS‐C4BINOL, demonstrated exceptionally high recognition affinities (up to 1012 M−1) towards 16 important steroidal compounds in aqueous solutions, establishing them the most effective known steroid receptors. The two C4BINOL enantiomers were employed to compose a fluorescent sensor array which achieved discrimination and sensing of 16 structurally similar steroids in biofluids.
Entanglement in multiple degrees of freedom has many benefits over entanglement in a single one. The former enables quantum communication with higher channel capacity and more efficient quantum ...information processing and is compatible with diverse quantum networks. Establishing multi-degree-of-freedom entangled memories is not only vital for high-capacity quantum communication and computing, but also promising for enhanced violations of nonlocality in quantum systems. However, there have been yet no reports of the experimental realization of multi-degree-of-freedom entangled memories. Here we experimentally established hyper- and hybrid entanglement in multiple degrees of freedom, including path (K-vector) and orbital angular momentum, between two separated atomic ensembles by using quantum storage. The results are promising for achieving quantum communication and computing with many degrees of freedom.
High‐mobility group protein box 1(HMGB1)is a ubiquitous highly conserved nuclear protein. Acting as a chromatin‐binding factor, HMGB1 binds to DNA and plays an important role in stabilizing ...nucleosome formation, facilitating gene transcription, DNA repairing, inflammation, cell differentiation, and regulating the activity of steroid hormone receptors. Currently, HMGB1 is discovered to be related to development, progression, and targeted therapy of lung cancer, which makes it an attractive biomarker, and therapeutic target. This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.
This review aims to encapsulate the relationship between HMGB1 and lung cancer, suggesting that HMGB1 plays a pivotal role in initiation, development, invasion, metastasis, and prognosis of lung cancer.
The successful design of refractory lining for a tundish is critical due to the demand of superheat control, improvement of steel cleanliness and reduction in material cost during continuous casting. ...A design of experiment analysis, namely, the Taguchi method, was employed to analyze two-dimensional heat transfer through refractory linings of a single-strand tundish, with the consideration of the thickness and the thermal conductivity of lining materials. In addition, a three-dimensional conjugate heat transfer model was applied in the tundish, taking in account the molten steel flow and heat conduction in the linings. A special focus of this study was to demonstrate the analysis methodology of combining Taguchi and CFD modelling to explore lining design in terms of thickness and thermal conductivity for the given process conditions during tundish operations.
This paper analyses the correlation between automobile exhaust, PM2.5, and air pollution to explore the rate of contribution of automobile exhaust to PM2.5 pollution and the effect of government ...regulation on automobile exhaust gas. The results show that the atmosphere is hazy and that car exhaust is the main cause of PM2.5 pollution. This paper divides the governance strategy into two methods: reducing the number of motor vehicles and reducing the emissions capacity of motor vehicles. It also analyses the effects of congestion control on public car travel and establishes a dynamic game model. To strengthen the influence of supervision on enterprises with regard to purifying devices and restrictions, this study also creates a “prisoner’s dilemma” model. The final results of the study show that restriction measures can effectively relieve road pressure. Additionally, congestion costs can alleviate environmental pressure, but it is difficult to determine the costs, and the difficulty of implementation increases. Increasing enterprises’ installation of purifying devices is not advisable or desirable in the short term. Finally, the paper offers some suggestions for the maintenance of the atmospheric environment and the management of automobile exhaust: (1) improve the national green transport system and environmental protection awareness; (2) advocate public transport as a mode of travel; and (3) reduce the use of buses and popularize new energy vehicles.
A quantum memory is a key component for quantum networks, which will enable the distribution of quantum information. Its successful development requires storage of single-photon light. Encoding ...photons with spatial shape through higher-dimensional states significantly increases their information-carrying capability and network capacity. However, constructing such quantum memories is challenging. Here we report the first experimental realization of a true single-photon-carrying orbital angular momentum stored via electromagnetically induced transparency in a cold atomic ensemble. Our experiments show that the non-classical pair correlation between trigger photon and retrieved photon is retained, and the spatial structure of input and retrieved photons exhibits strong similarity. More importantly, we demonstrate that single-photon coherence is preserved during storage. The ability to store spatial structure at the single-photon level opens the possibility for high-dimensional quantum memories.
The strong interdependence between the Seebeck coefficient, the electrical and thermal conductivity makes it difficult to obtain a high thermoelectric figure of merit, ZT. It is of critical ...significance to design a novel structure that manages to decouple these parameters. Here, we combine a liquid state manipulation method for solidified Bi0.5Sb1.5Te3 alloy with subsequent melt spinning, ball milling, and spark plasma sintering processes, to construct dedicated microstructures containing plenty of 60° twin boundaries. These twin boundaries firstly scatter the very low-energy carriers and lead to an enhancement of the Seebeck coefficient. Secondly, they provide a considerable high carrier mobility, compensating the negative effect of the reduced hole concentration on the electrical conductivity. Thirdly, both experimental and calculated results demonstrate that the twin-boundary scattering dominates the conspicuous decrease of the lattice thermal conductivity. Consequently, the highest ZT value of 1.42 is achieved at 348K, which is 27% higher than that of the sample with less twin boundary treated without liquid state manipulation. The average ZT value from 300K to 400K reaches 1.34. Our particular sample processing methods enabling the twin-dominant microstructure is an efficient avenue to simultaneously optimize the thermoelectric parameters.
Display omitted
•Synthesizing samples using powder sintering based on liquid state manipulation.•Generating large number of twin boundaries for Bi0.5Sb1.5Te3 alloy.•Simultaneous optimization of electrical and thermal properties due to twin boundary.•A 27% enhancement of ZT compared with twin-less sample treated without liquid state manipulation.
We recently demonstrated that overexpression of HOTAIR (Hox transcript antisense intergenic RNA) was associated with tumor progression and radio‐resistance in human cervical cancer. Considering the ...single nucleotide polymorphism (SNP) rs920778 (C>T) could influence HOTAIR expression and cancer predisposition in other malignancies, we herein investigated the association between rs920778 status and cervical cancer susceptibility in a Chinese population. Using the specific TaqMan PCR assay, we genotyped rs920778 in 215 cervical cancer patients and 430 age‐matched healthy controls. As shown in our data, TT genotype of rs920778 was significantly correlated with the upregulation of HOTAIR (p = 0.008). Compared with the healthy control, TT genotype and T allele notably indicated a much higher risk of cervical cancer TT genotype: odds ratio (OR) = 2.186, 95% confidence interval (CI) = 1.378–3.466, p = 0.003; T allele: OR = 1.556, 95% CI = 1.221–1.981. In addition, we also found that the TT genotype of rs920778 was correlated with advanced tumor stage (p = 0.039), highly histological grade (p = 0.013), lympho node metastasis (p < 0.001) and positive infection of high risk HPV (p < 0.001). Among the patients who underwent concurrent chemo‐radiotherapy, TT genotype carriers present notably resistance to the combination of EBRT + ICBT + cisplatin (p = 0.023). In conclusion, we firstly reported that TT genotype of HOTAIR rs920778 was significantly associated with the cervical cancer susceptibility. Moreover, the TT genotype of rs920778 might be a potent prognostic marker in cervical cancer patients.
PDF
