Balance dysfunctions in stroke survivors are common and have significant impact on functional independence and rehabilitation. As a crucial technique of Traditional Chinese Medicine, acupuncture has ...been used widely for balance dysfunctions after stroke, although its effective evidence is not clear. Hence, we plan this systematic review protocol to evaluate the value of its efficacy and safety for balance dysfunctions after stroke.
We will search the databases from the publishment to April 2018: Web of Science, PubMed, Medline, Cochrane Library, EBASE, WHO International Clinical Trials Registry Platform, Wanfang, Chinese Biomedical Literature Database, Chinese Scientific Journal Database (VIP), and China National Knowledge Infrastructure. The clinical efficacy will be accepted as the primary outcomes. RevMan V.5.3 software will be used to compute the data synthesis when a meta-analysis is allowed.
This systematic review and meta-analysis will provide a high-quality synthesis of current evidence of acupuncture for balance dysfunctions after stroke including clinical efficacy, balance ability, walking ability, and activity of daily life etcetera.
This protocol will determine whether acupuncture is an effective and safety intervention for balance dysfunctions after stroke.
In the mol-ecule of the title compound, C(14)H(16)N(2)O(3), the dihedral angle between the pyridyl rings is 87.74 (3)°. In the crystal structure, inter-molecular C-H⋯O hydrogen bonds link the ...mol-ecules into infinite zigzag chains.
The development of artificial receptors that combine ultrahigh‐affinity binding and controllable release for active guests holds significant importance in biomedical applications. On one hand, a ...complex with an exceedingly high binding affinity can resist unwanted dissociation induced by dilution effect and complex interferents within physiological environments. On the other hand, stimulus‐responsive release of the guest is essential for precisely activating its function. In this context, we expanded hydrophobic cavity surface of a hypoxia‐responsive azocalix4arene, affording Naph‐SAC4A. This modification significantly enhanced its aqueous binding affinity to 1013 M−1, akin to the naturally occurring strongest recognition pair, biotin/(strept−)avidin. Consequently, Naph‐SAC4A emerges as the first artificial receptor to simultaneously integrate ultrahigh recognition affinity and actively controllable release. The markedly enhanced affinity not only improved Naph‐SAC4A′s sensitivity in detecting rocuronium bromide in serum, but also refined the precision of hypoxia‐responsive doxorubicin delivery at the cellular level, demonstrating its immense potential for diverse practical applications.
A hypoxia‐responsive azocalix4arene (Naph‐SAC4A) has been developed that can achieve a biotin/(strept−)avidin‐level binding affinity (up to 1013 M−1 ) through its expanded hydrophobic surface. Naph‐SAC4A demonstrated the sensitive recognition of rocuronium in serum and a hypoxia‐responsive delivery of doxorubicin with minimum leakage at the cellular level.
The development of artificial receptors that combine ultrahigh‐affinity binding and controllable release for active guests holds significant importance in biomedical applications. On one hand, a ...complex with an exceedingly high binding affinity can resist unwanted dissociation induced by dilution effect and complex interferents within physiological environments. On the other hand, stimulus‐responsive release of the guest is essential for precisely activating its function. In this context, we expanded hydrophobic cavity surface of a hypoxia‐responsive azocalix4arene, affording Naph‐SAC4A. This modification significantly enhanced its aqueous binding affinity to 1013 M−1, akin to the naturally occurring strongest recognition pair, biotin/(strept−)avidin. Consequently, Naph‐SAC4A emerges as the first artificial receptor to simultaneously integrate ultrahigh recognition affinity and actively controllable release. The markedly enhanced affinity not only improved Naph‐SAC4A′s sensitivity in detecting rocuronium bromide in serum, but also refined the precision of hypoxia‐responsive doxorubicin delivery at the cellular level, demonstrating its immense potential for diverse practical applications.
Detecting microwave signals over a wide frequency range has numerous advantages as it enables simultaneous transmission of a large amount of information and access to more spectrum resources. This ...capability is crucial for applications such as microwave communication, remote sensing, and radar. However, conventional microwave receiving systems are limited by amplifiers and band-pass filters that can only operate efficiently in a specific frequency range. Typically, these systems can only process signals within a three-fold frequency range, which limits the data transfer bandwidth of the microwave communication systems. Developing novel atom-integrated microwave sensors, for example, radio frequency (RF)-chip coupled Rydberg atomic receiver, provides opportunities for a large working bandwidth of microwave sensing at the atomic level. Here, an ultra-wide dual-band RF sensing scheme is demonstrated by space-division multiplexing two RF-chip-integrated atomic receiver modules. The system can simultaneously receive dual-band microwave signals that span a frequency range exceeding 6 octaves (300 MHz and 24 GHz). This work paves the way for multi-band microwave reception applications within an ultra-wide range by RF-chip-integrated Rydberg atomic sensor.
Engineering a Terahertz (THz) frequency comb spectroscopy at atomic level advances the precisely measurement in spectroscopy and sensing. Current progresses on THz frequency comb rely on ...difference-frequency generation, optical parametric oscillation, and other methods. Generating a THz frequency comb poses challenges in source stability and achieving a narrow bandwidth, which traditional THz devices are difficult to achieve. Furthermore, accurately measuring the generated THz frequency comb necessitates a high-performance THz detector. Rydberg atoms are well-suited for electric field sensing due to their ultra-wide radio frequency transition energy levels, making them especially sensitive to external electric fields in the DC to THz bandwidth. However, there have been no reports about generating THz frequency comb spectroscopy at the atomic level until now. This work presents a THz frequency comb spectroscopy with Rydberg atoms, in which a Floquet comb-like transition is engineered through a time-periodic drive field. Our approach simplifies the setup required for THz frequency comb spectroscopy while extending the working bandwidth for Rydberg atomic sensors. The THz frequency comb spectroscopy at the atomic level reported in this article shows great potential for various applications in astronomy, remote sensing, spectral detection of biological samples, and other related fields.
Developing microwave electric field sensing based on Rydberg atom has received significant attention due to its unique advantages. However, achieving effective coupling between Rydberg atom and the ...microwave electric field in the sensing process is a challenging problem that greatly impacts the sensitivity. To address this, we propose the use of a microwave resonant cavity to enhance the effective coupling between the Rydberg atoms and the microwave electric field. In our experiment, we use a three-photon excitation scheme to prepare Rydberg atoms, make measurements of electric fields without and with a microwave cavity in which the vapor cell is put inside. Through experimental testing, we achieve an 18 dB enhancement of power sensitivity. The experiment shows an effective enhancement in electric field pulse signal detection. This result provides a promising direction for enhancing the sensitivity of Rydberg atomic electric field sensors and paves the way for their application in precision electric field measurements.
Purified konjac glucomannan(KGM) was blended with Xanthan gum to prepared gel, which was valued by its viscosity and tenacity. The konjac micro-balls(KMBs) were prepared in drying and wetting method ...respectively. The diameter of the KMBs was analyzed with laser particle size analyzer. To a carrier of drug deliver, the delivery characteristics of the NMP, which embedded in KMB, was discussed. The results showed that KMB was well dispersed in DMSO, and its diameter was 4.08μm. In paraffin, KMB was homogeneous disperse with diameter(2.23μm). In the behavior of drug delivery, the characteristics of drug sustained-release were obvious, and the delivery time was more than 24h.
Utilizing mycoremediation is an important direction for managing heavy metal pollution. Zn
pollution has gradually become apparent, but there are few reports about its pollution remediation. Here, ...the Zn
remediation potential of
, an anamorph of the entomopathogenic fungus
, was explored. There was 60% Zn
removed by
mycelia from a Zn
-contaminated medium. To reveal the Zn
tolerance mechanism of
, transcriptomic and metabolomic were executed. Results showed that Zn
caused a series of stress responses, such as energy metabolism inhibition, oxidative stress, antioxidant defense system disruption, autophagy obstruction, and DNA damage. Moreover, metabolomic analyses showed that the biosynthesis of some metabolites was affected against Zn
stress. In order to improve the tolerance to Zn
stress, the metabolic mechanism of metal ion transport, extracellular polysaccharides (EPS) synthesis, and microcycle conidiation were activated in
. Remarkably, the formation of microcycle conidiation may be triggered by reactive oxygen species (ROS) and mitogen-activated protein kinase (MAPK) signaling pathways. This study supplemented the gap of the Zn
resistance mechanism of
and provided a reference for the application of
in the bioremediation of heavy metals pollution.
The GABA
receptor (GABA
R) agonist baclofen has been used to treat alcohol and several other substance use disorders (AUD/SUD), yet its underlying neural mechanism remains unclear. The present study ...aimed to investigate cortical GABA
R dynamics following chronic alcohol exposure. Ex vivo brain slice recordings from mice chronically exposed to alcohol revealed a reduction in GABA
R-mediated currents, as well as a decrease of GABA
R and G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) activities in the motor cortex. Moreover, our data indicated that these alterations could be attributed to dephosphorylation at the site of serine 783 (ser-783) in GABA
subunit, which regulates the surface expression of GABA
R. Furthermore, a human study using paired-pulse-transcranial magnetic stimulation (TMS) analysis further demonstrated a reduced cortical inhibition mediated by GABA
R in patients with AUD. Our findings provide the first evidence that chronic alcohol exposure is associated with significantly impaired cortical GABA
R function. The ability to promote GABA
R signaling may account for the therapeutic efficacy of baclofen in AUD.
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