A
bstract
Based on 4.5 fb
−
1
data taken at seven center-of-mass energies ranging from 4.600 to 4.699 GeV with the BESIII detector at the BEPCII collider, we measure the branching fractions of
Λ
c
+
...→
Σ
+
+
hadrons
relative to
Λ
c
+
→
Σ
+
π
+
π
−
. Combining with the world average branching fraction of
Λ
c
+
→
Σ
+
π
+
π
−
, their branching fractions are measured to be (0
.
377
±
0
.
042
±
0
.
020
±
0
.
021)% for
Λ
c
+
→
Σ
+
K
+
K
−
, (0
.
200
±
0
.
023
±
0
.
011
±
0
.
011)% for
Λ
c
+
→
Σ
+
K
+
π
−
, (0
.
414
±
0
.
080
±
0
.
030
±
0
.
023)% for
Λ
c
+
→
Σ
+
ϕ
and (0
.
197
±
0
.
036
±
0
.
009
±
0
.
011)% for
Λ
c
+
→ Σ
+
K
+
K
−
(non-
ϕ
). In all the above results, the first uncertainties are statistical, the second are systematic and the third are from external input of the branching fraction of
Λ
c
+
→
Σ
+
π
+
π
−
. Since no signal for
Λ
c
+
→
Σ
+
K
+
π
−
π
0
is observed, the upper limit of its branching fraction is determined to be 0.13% at the 90% confidence level.
To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical ...properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and <0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. To bridge the one order of magnitude in the detector size difference between Daya Bay and JUNO, the Daya Bay data were used to tune the parameters of a newly developed optical model. Then, the model and tuned parameters were used in the JUNO simulation. This enabled to determine the optimal composition for the JUNO LS: purified solvent LAB with 2.5 g/L PPO, and 1 to 4 mg/L bis-MSB.
A combination of comparative analysis of gene expression profiles between normal tissue samples and small cell lung cancer (SCLC) samples and network analysis was performed to identify key genes in ...SCLC.
Microarray data set GSE43346 was downloaded from Gene Expression Omnibus (GEO), including 43 normal tissue samples and 23 clinical SCLC samples. Differentially expressed genes (DEGs) were screened out with t-test. Coexpression network and gene regulatory network were then constructed for the DEGs. GO enrichment analysis as well as KEGG pathway were performed with DAVID online tools to reveal over-represented biological processes.
A total of 457 DEGs were obtained in SCLC, 259 up-regulated and 198 down-regulated. Some of them exhibited enzyme inhibitor activity and chemokine activity. A coexpression network including 457 nodes was constructed, from which a functional module was extracted. Genes in the modules were closely related with cell cycle. Top 10 nodes in the regulatory network were acquired and their sub-networks were extracted from the whole network. Genes in these sub-networks were related to cell cycle, apoptosis and transcription. A network comprising 43 microRNAs (miRNAs) and their target genes (also DEGs) were also constructed. Regulation of cell proliferation, cell cycle and regulation of programmed cell death were over-represented in these genes.
A range of DEGs were revealed in SCLC, which could enhance the understandings about the pathogenesis of this disease and provide potential molecular targets for diagnosis as well as treatment.
Abstract
3D non-equilibrium molecular dynamics simulations are performed to investigate the friction characteristic of Fe-Fe tribopair system under third medium condition. A Fe-Fe sliding simulation ...model with the soft third medium (Cu nanoparticle) is built. The Friction force, evolution of the structure of interface and the temperature profiles of the sliding system are obtained. The influence of the sliding velocity to the temperature and structure change under third medium is investigated. The influence of Cu nanoparticle to the microstructure evolution and change of the friction characteristic is extremely concerned. The results show that the Cu nanoparticle can decrease the friction force and average temperature under the relatively low velocity (25m/s). However, under high velocity (150m/s), the positive effect is not obvious. A Cu nano-film would form on the surface, which is useful for weakening the destruction of the interface, and protecting the sliding blocks. Under high velocity, a mixing layer would be formed in both two cases (with or without Cu nanoparticle).
A bstract Using e + e − collision data collected with the BESIII detector at the BEPCII collider at center-of-mass energies between 3.510 and 4.914 GeV, corresponding to an integrated luminosity of ...25 fb − 1 , we measure the Born cross sections for the process $$ {e}^{+}{e}^{-}\to {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ e + e − → K − Ξ ¯ + Λ / Σ 0 at thirty-five energy points with a partial-reconstruction strategy. By fitting the dressed cross sections of $$ {e}^{+}{e}^{-}\to {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ e + e − → K − Ξ ¯ + Λ / Σ 0 , evidence for $$ \psi (4160)\to {K}^{-}{\overline{\Xi}}^{+}\Lambda $$ ψ 4160 → K − Ξ ¯ + Λ is found for the first time with a significance of 4.4 σ , including systematic uncertainties. No evidence for other possible resonances is found. In addition, the products of electronic partial width and branching fraction for all assumed resonances decaying into $$ {K}^{-}{\overline{\Xi}}^{+}\Lambda /{\Sigma}^0 $$ K − Ξ ¯ + Λ / Σ 0 are determined.
The association between the rs2230199 C>G single nucleotide polymorphism (SNP) in complement component 3 and age-related macular degeneration (AMD) risk has been examined extensively but the results ...are not consistent among studies. The aim of this study was to perform a meta-analysis of all available studies on this SNP in relation to AMD. The comprehensive databases of PubMed, Medline, Web of Knowledge, CNKI, and Google Scholar were searched for case-control studies investigating the association between the rs2230199 polymorphism and AMD susceptibility. ORs with 95%CIs were estimated to assess the association. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed. A total of 15 published studies including 5593 cases and 5181 controls were used in this meta-analysis. Overall, the rs2230299 SNP was significantly associated with the risk of AMD in the overall population under the additive model (OR = 1.571, 95%CI = 1.414-1.745, P = 0.000), dominant model (OR = 1.681, 95%CI = 1.521-1.858, P = 0.000), and allelic model (OR = 1.597, 95%CI = 1.470-1.734, P = 0.000). In the subgroup analysis by ethnicity, the same results were found in Caucasian populations, while no significant correlations were found in Asian populations for all comparison models. In conclusion, our meta-analysis provides evidence that the rs2230199 polymorphism contributes to the development of AMD. Further large-scale multicenter epidemiological studies are warranted to confirm this finding.
The aim of this study was to investigate the outcome in 556 patients with locally advanced nasopharyngeal carcinomas treated by radiation therapy alone. We observed 556 patients with stage T3-4 and ...N0-3 carcinoma who were treated by conventional radiotherapy alone between January and December 1999. The total dose delivered to the nasopharynx was 66-80 Gy over 6.5-8 weeks and to the neck lymph nodes 60-70 Gy over 6-7 weeks. The 5-year actuarial overall survival rate (OS) reached 66.41%. The OS was higher among stage T3 patients than among stage T4 patients (69.12% vs 58.96%, p = 0.0359). Among patients with stage N0, N1, N2 and N3 disease, the OS was 73.98%, 65.96%, 57.58% and 29.39%, respectively (p = 0.0009). Differences in disease-free survival, locoregional control rate and metastasis-free survival rate among each N stage were statistically significant, although this was not true of differences between stage T3 and T4 disease. Multivariate analysis showed that gender, age, T stage and N stage were significant prognostic factors for 5-year overall survival, disease-free survival, locoregional control and metastasis-free survival. We found that N stage is the dominant prognostic indicator for patients with locally advanced nasopharyngeal carcinoma receiving conventional radiation therapy alone, and that T stage was only a secondary correlative factor.
An enzyme purified from the ovaries of Helicoverpa armigera, as an active form with molecular mass of 30 kDa on SDS‐PAGE, was identified as a cysteine proteinase because it could be inhibited by ...E‐64, a specific inhibitor of cysteine proteinase, and required reducing conditions for activity. This enzyme was further identified as a cathepsin B‐like cysteine proteinase by partial amino acid sequencing. A cDNA encoding this proteinase was cloned from H. armigera, using degenerate primers and RACE techniques. Results of Northern blots indicated that the mRNA encoding the proteinase was transcribed in the ovaries, the fat bodies of female and male adults, pupae and in the larvae. No mRNA was detected from the larval epidermis or from the midgut. Hence, transcription of the cathepsin B‐like cysteine proteinase from H. armigera was tissue‐specific, but not gender‐ or developmental stage‐specific. However, proteolytic activities were only detected from ovaries, and adult female and male fat bodies. No activity was observed from pupal and larval fat bodies, from the larval epidermis or from the midgut. Only one form of mRNA of ≈ 1100 bases was detected, and in situ hybridization showed that the transcripts were distributed in the adult female fat bodies, follicular cells and the oocytes. Since the proteinase expressed in ovaries was able to degrade vitellin in vitro, it may be involved in the degradation of vitellin during embryonic development.
A bstract We measured the Born cross sections for the process e + e − → ωη ′ at 22 center-of-mass energies from 2.000 to 3.080 GeV with the BESIII detector at the BEPCII collider. We observed a ...resonant structure with a statistical significance of 9.6 σ . A Breit-Wigner fit determines its mass to be M R = (2153 ± 30 ± 31) MeV /c 2 and its width to be Γ R = (167 ± 77 ± 7) MeV, where the first uncertainties are statistical and the second are systematic.
Human migration plays an important role in the city spatial evolution. This paper presents a new simulation model of city spatial evolution that explicitly considers preference and exploration in the ...migration choice decision process. In the model, the preference means that human prefer to move to the communities which have more people, while the exploration implies that human wish to explore the unknown communities randomly. By introducing the carrying capacity (CC), maximum movement distance (MMD), migration rate (MR) and random migration parameter (RMP), we investigate the effects of them on the city spatial distribution. All of the parameters can govern how many people can live in each community, how far people can explore and how many people move per time step, etc. A numerical simulation experiment is presented to illustrate that the form of the city is centralized with the increase of CC, MMD and MR, while it will be decentralized as the RMP grows.
•Considering the carrying capacity of community in the city evolution, we find that the distribution of population in the city is more uniform.•The maximum movement distance has a great influence on the centralization of population distribution.•Preference and higher migration rate will lead to the generation of larger communities.•The randomly exploration will cause the dispersed population distribution.
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