We reviewed cytogenetic studies that have been done in 1,000 consecutive non-oncology samples that were referred to the Cytogenetics Unit at King Khalid University Hospital, Riyadh, Saudi Arabia. The ...cases were grouped according to the referral diagnosis and the requested cytogenetic service. The frequency of the different types of numerical and structural abnormalities was determined and the relative frequency of cases with abnormal karyotype was calculated in each group. This study should assist physicians in Saudi Arabia and surrounding countries by increasing the awareness of the frequency of cytogenetic abnormality in different diagnostic groups. It also gives figures for comparison with other countries and research centers.
Priapism is rare‐presenting feature in male patients with chronic myeloid leukemia (CML). Several hypotheses for pathogenesis have been described. Management has been controversial; some authors ...described resolution following priapism‐specific interventions, and others recommended addition of CML‐specific therapy or even CML‐specific therapy alone.
In this report, we describe presentation and management of a man with refractory priapism that was the first presenting manifestation of CML. We also report, for the first time, the pathology sections of the sinusoidal tissue in such cases. Literature is reviewed for similar cases and their outcome.
A 21‐year‐old male patient presented with painful priapism that started 6 days earlier and failed aspiration–irrigation. CBC revealed marked leucocytosis. Oncology care diagnosed CML, and treatment with Imatinib was commenced with prior semen cryopreservation. Following remission, a penile prosthesis was implanted, assisted by optical corporotomy. Sinusoidal tissue biopsy was stained by hematoxylin/eosin (H&E) and CD34.
Pathology sections of cavernous tissue following CML‐induced priapism.
The penile implant survived without complications. H&E examination of the sinusoidal tissue biopsy revealed leukemic infiltration associated with vascular endothelial damage. CD34 staining showed the mixed picture of leukemic infiltrates, intact vascular endothelium with lumena showing leukemic cells, alternating with destroyed vessels, and no vascular lumena and ruminants of endothelial cells.
Priapism can be the first manifestation of previously undetected CML. The pathological picture of sinusoidal tissue in such cases is presented. In the case at hand, a complete blood picture was helpful in early diagnosis of CML and early initiation of targeted chemotherapy along with the corporal irrigation/aspiration or shunt surgery. It is therefore recommended to have a CBC examined at presentation of any case of ischemic priapism of unknown etiology, early initiation of CML therapy along with aspiration/irrigation, preferably cryopreserving a semen sample before CML therapy. Shaeer OKZM, Shaeer KZM, AbdelRahman IFS, El‐Haddad MS, and Selim OM. Priapism as a result of chronic myeloid leukemia: Case report, pathology, and review of the literature. J Sex Med 2015;12:827–834.
This paper demonstrates the use of multi-agent systems (MAS), firstly as a modelling technique for dynamic physical systems and secondly as the basis for a generic and powerful diagnostic system, ...which can support heterogeneous distributed systems. First an overview of the diagnostic techniques including those offered by the two communities fault detection and isolation (FDI ) and DX (based on intelligent techniques) is given. The use of digital signal processing (DSP) as a significant technique for improved fault diagnosis is illustrated. A rule-based engine is used to control the behaviours of the agents and also as a tool for diagnosis. Finally, the integration of DSP agents and the rule-based engine into MAS is demonstrated using a real-life application, a class-AB amplifier (a power electronic circuit). It is shown that the integration of DSP agents and rules into MAS provides a powerful tool for prognosis and for detection of abrupt (short and open circuit) and incipient faults.
In this paper intelligent agents and DSP techniques are integrated to detect single and multiple faults in electrical circuits. Agents are used to model the AC electrical circuit. A DSP engine is ...embedded into the agents to analyse the signals, i.e. the energy transfer between the physical components. An AC to DC rectifier circuit is chosen as test-bed for the proposed solutions
We report on the corporal rotation technique, customized for the management of ventral curvature in patients without hypospadias.
A male patient with ventral curvature of 90 degrees was operated on. ...The neurovascular bundle was mobilized for a short distance at the point of maximum curvature. The corpora cavernosa were approximated to each other in the dorsal midline by suturing pairs of longitudinal parallel incisions. To avoid urethral narrowing, minimal dissection was used to develop the groove on either side of the corpus spongiosum, to release it from its attachment to the rotated corpora cavernosa.
Full correction of the curvature was achieved, without shortening, erectile dysfunction, or micturition problems.
Corporal rotation can be applied for the correction of ventral penile curvature in patients with and without hypospadias, without sacrificing penile length. Shaeer O. Correction of penile curvature by rotation of the corpora cavernosa: a case report. J Sex Med 2006;3:932–937.
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