Objective: Though autonomous emergency braking (AEB) systems for car-to-cyclist collisions have been under development, an estimate of the benefit of AEB systems based on an analysis of accident data ...is needed for further enhancing their development. Compared to the data available from in-depth accident data files, data provided by drive recorders can be used to reconstruct car-to-cyclist collisions with greater accuracy because the position of cyclists can be observed from the videos. In this study, using data from drive recorders, the performance and limitations of AEB systems were investigated.
Method: Data of drive recorders involving taxi-to-cyclist collisions were collected. Using the images collected from the drive recorders of those taxis, 40 cases of 90° car-to-cyclist intersection collisions were reconstructed using PC-Crash. Then, the collisions were reconstructed again utilizing car models with AEB systems installed while changing the sensor's field of view (FOV) and the delay time of initiating vehicle deceleration.
Results: The angle of FOV has a significant influence on avoiding car-to-cyclist collisions. Using a 50° FOV with a braking delay time of 0.5 s resulted in avoiding 6 collisions, and using a 90° FOV resulted in avoiding an additional 14 collisions. Even when installing an ideal AEB system providing 360° FOV and no delay time for braking, 8 collisions were not avoided, though the impact velocities were reduced for all of these remaining collisions. These collisions were caused by the cyclists' sudden appearance in front of cars, and the time-to-collision (TTC) when the cyclists appeared was less than 0.9 s.
Conclusion: The AEB systems were effective for mitigating collisions that occurred due to driver perception delay. Because cyclists have a traveling velocity, a wide-angle FOV is effective for reduction of car-to-cyclist intersection collisions. The reduction of delay time in braking can reduce the number of collisions that are close to the braking performance limit. The collisions that remained even with an ideal AEB system in the PC-Crash simulation indicate that such collisions could still occur for autonomous cars if the traffic environment does not change.
20 (R)-25-methoxyl-dammarane-3β, 12β, 20-triol (AD-1), a novel ginsenoside isolated from stem and leaf of Panax Notoginseng, has anticancer activity against a variety of malignant tumors. However, ...the pharmacological mechanism of AD-1 on colorectal cancer (CRC) remains unclear. The purpose of this study was to verify the potential mechanism of action of AD-1 against CRC through network pharmacology and experiments. A total of 39 potential targets were obtained based on the intersection of AD-1 and CRC targets, and key genes were analyzed and identified from the PPI network using Cytoscape software. 39 targets were significantly enriched in 156 GO terms and 138 KEGG pathways, among which PI3K-Akt signaling pathway was identified as one of the most enriched pathways. Based on experimental results, AD-1 can inhibit the proliferation and migration of SW620 and HT-29 cells, and induce their apoptosis. Subsequently, the HPA and UALCAN databases showed that PI3K and Akt were highly expressed in CRC. AD-1 also decreased the expressions of PI3K and Akt. In summary, these results suggest that AD-1 can play an anti-tumor role by inducing cell apoptosis and regulating PI3K-Akt signaling pathway.
Response surface methodology (RSM) was used to determine the optimal conditions for ultrasound-assisted extraction (UAE) of Notoginsenoside Fc (Fc) from panax notoginseng leaves. The experiment ...utilized a Box-Behnken design (BBD) and separation conditions were optimized. The optimum extraction conditions were as follows: extraction time = 1.5 h, ethanol concentration = 86%, liquid-to-solid ratio = 19:1. The experimentally obtained values were in accordance with the values predicted by the RSM model. We determined that the RSM model was able to successfully simulate the optimal extraction of Fc from the leaves. Further, Fc was enriched from
through nine macroporous resins, and HPD-100 macroporous resins were selected for preliminary enrichment of Fc due to its economic costs and benefits. Subsequently, octadecyl silane (ODS) column chromatography was used to improve the purity of Fc to over 90% after separation by ODS column chromatography. Fc with a purity greater than 95% can be obtained by recrystallization. This is the first study that has focused on the extraction and enrichment of Fc from
leaves using macroporous resin combined with ODS column chromatography, which provides the possibility for further application of Fc.
•Twenty-one cucurbitane triterpenoids were isolated from the fruit of bitter melon.•Two new cucurbitane glycosides were isolated from the fruits ofbitter melon.•The hypoglycemic inhibition of 21 ...cucurbitane triterpenoids have been evaluated.•All compounds exhibiting α-glucosidase inhibitory activity.
Momordica charantia L. has been widely used in different countries as a functional food source, particularly as a remedy for type 2 diabetes. In the present study, 21 cucurbitane-type triterpenoids, including two new compounds named charantoside IX and X (1−2), were isolated from the extract of M. Charantia L.Their chemical structures were identified by 1D, 2D-NMR and FT-ICR-MS techniques. Three anti-diabetes target assays of all triterpenoids were carried out, with all compounds exhibiting α-glucosidase inhibitory activity. Particularly, compounds 6, 9 and 11 exhibited excellent α-glucosidase inhibitory activity with IC50 values of 10.19, 28.55, and 20.20μM, respectively. Some of the tested isolates showed inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) and α-amylase, with compound 6 exhibiting the strongest activity against PTP1B. These chemical and biological results indicated that cucurbitane triterpenoids in functional foodsmay represent attractive candidates for regulation of blood glucose levels.
Energy security could be jointly maintained through the cooperation of different countries or regions. In this circumstance, there has been a large number of energy-related international investment ...studies. However, the existing academic literature lacks a systematic scientometric analysis of this research topic, so this paper will fill this gap. Using CiteSpace, VOSviewer, and HisCite, this paper analyzes 1014 articles published in the WoS SSCI Collection from January 1998 to March 2022 on the energy-related international investment. This paper comprehensively analyzes this field from four evolutionary dimensions. In the discipline and mainstream journals dimension, the largest change lies in the fact that more than three different disciplines flow into mathematics, while the journal “Environmental Science and Pollution Research” shows a dramatic growth in relevant publications after 2015. Keyword evolution shows a gradual deepening emphasis from attracting energy-related international investment to systematically analyzing the influencing mechanisms of the international investment-energy-environmental quality nexus. Citation clusters identifies two latest clusters, including institutional quality and renewable energy consumption. Citation paths summarize four major evolutionary paths. The overall evolution trend is based on the FDI-energy-environment nexus, and gradually considers the influence mechanism of different factors on this nexus.
As the main component of
, cedrol has known germinal activity. A range of cedrol formulations have been developed to prevent hair-loss, but compliance remains key issues. In this study, we prepared ...cedrol nanoemulsion (CE-NE) and determined the particle size and PDI (polydispersion coefficient), investigated the hair growth activity and studied the bioavailability in vitro and in vivo. Results showed that the average particle size of CE-NE is 14.26 ± 0.16 nm, and the PDI value is 0.086 ± 0.019. In vitro drug release investigation and drug release kinetics analysis showed release profile of CE from nanoparticles demonstrates the preferred partition of CE in buffer pH 4.0, the release profile of CE-NE showed a first-order kinetics reaching around 36.7% after 6 h at 37 °C. We artificially depilated the back hair of C57BL/6 mice and compared the efficacy of a designed cedrol nanoemulsion to an existing ointment group. The hair follicles were imaged and quantified using a digital photomicrograph. The results showed that compared with the ointment, CE-NE had positive effects on hair growth, improved drug solubility. Compared with the ointment and 2% minoxidil groups, 50 mg/mL CE-NE led to more robust hair growth. Pharmacokinetics analysis showed that the AUC
of CE-NE was 4-fold higher than that of the ointment group, confirming that the bioavailability of the nanoemulsion was greater than that of the ointment. CE-NE also significantly reduced the hair growth time of model mice and significantly increased the growth rate of hair follicles. In conclusion, these data suggest that the nanoemulsion significantly improved the pharmacokinetic properties and hair growth effects cedrol, enhancing its efficacy in vitro and in vivo.
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease that can cause severe pain and dysfunction. It has a serious impact on the quality of lives of patients. Since ...mechanism underlying the pathogenesis of TMJOA is not fully understood, the development of effective tools for early diagnosis and disease-modifying therapies has been hindered. Animal models play a key role in understanding the pathological process of diseases and evaluating new therapeutic interventions. Although some similarities in disease processes between animals and humans are known, no one animal model is sufficient for studying all characteristics of TMJOA, as each model has different translatability to human clinical conditions. For the past 4 decades, TMJOA animal models have been studied by numerous researchers and can be broadly divided into induced, naturally occurring, and genetically modified models. The induced models can be divided into invasive models (intra-articular injection and surgical induction) or non-invasive models (mechanical loading, high-fat diet, and sleep deprivation). Different types of animal models simulate different pathological expressions of TMJOA and have their unique characteristics. Currently, mice, rats, and rabbits are commonly used in the study of TMJOA. This review sought to provide a general description of current experimental models of TMJOA and assist researchers in selecting the most appropriate models for different kinds of research.
The
, known as 'Feng Dan', has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, ...paeobenzofuranones A-E (
-
), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds
,
, and
showed cytotoxicity against three human cancer cell lines, with IC
values ranging from 6.7 to 25.1 μM. Compounds
and
showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of
are reported for the first time in this paper.
This study aimed to investigate the protective effect of black raspberry anthocyanins (BRAs) against acute and subacute alcoholic liver disease (ALD). Network analysis and docking study were carried ...out to understand the potential mechanism. Thereafter, the serum biochemical parameters and liver indexes were measured, the histopathological changes of the liver were analyzed in vivo. The results showed that all tested parameters were ameliorated after the administration of BRAs with alcohol. Meanwhile, there was increased protein expression of NF-κB and TGF-β in extracted livers, which was associated with hepatitis and hepatic fibrosis. Furthermore, BRAs and cyanidin-
-
-rutinoside exhibited cytotoxic effects on t-HSC/Cl-6, HepG2, and Hep3B and induced the apoptosis of HepG2 cells; downregulated the protein expression level of Bcl-2; upregulated the level of Bax; and promoted the release of cytochrome C, cleaved caspase-9, cleaved caspase-3, and cleaved PARP in HepG2 cells. In addition, the antioxidant activity of BRAs was tested, and the chemical components were analyzed by FT-ICR MS. The results proved that BRAs exert preventive effect on ALD through the antioxidant and apoptosis pathways.
In this paper, phosphoric acid (H3PO4), hydrochloric acid (HCl), and hydrogen peroxide (H2O2) were employed for the modification of oil-based drill cutting ash (OBDCA) for the first time. The ...adsorption of rhodamine B (RhB) on modified oil-based drill cutting ash (MOBDCA) in an aqueous medium was investigated. H2O2-modified OBDCA had the optimal adsorption efficiency for RhB. The physical and chemical properties of MOBDCA were analyzed using X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), ζ-potential, N2 adsorption–desorption isotherm, and pore size distribution. The effect of the pH value (3–11), reaction time (10–720 min), and initial RhB concentration (10–200 mg/L) on RhB adsorption was discussed. The adsorption kinetics highly fitted with the pseudo-second-order model (R 2 > 0.99), which indicated that the adsorption process was dominated by chemisorption. The adsorption isotherm fitted well with the Langmuir and Freundlich models (R 2 > 0.97), which indicated the monolayer adsorption process and the heterogeneous adsorption process, respectively. The theoretic adsorption capacity (50 mg/g) for RhB was achieved by H2O2-modified OBDCA. This paper provides a promising method of resource utilization of OBDCA to treat organic pollutants.
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