Olfactomedin-related proteins are secreted glycoproteins with conserved C-terminal motifs.
Olfactomedin was originally identified as the major component of the mucus layer that surrounds
the ...chemosensory dendrites of olfactory neurons. Homologues were subsequently found also in
other tissues, including the brain and in species ranging from Caenorhabditis elegans to Homo
sapiens. Most importantly, the TIGR/myocilin protein, expressed in the eye and associated with
the pathogenesis of glaucoma, is an olfactomedin-related protein. The prevalence of olfactomedin-related proteins among species and their identification in different tissues prompted us to
investigate whether a gene family exists within a species, specifically Homo sapiens. A GenBank
search indeed revealed an entire human gene family of olfactomedin-related proteins with at least
five members, designated hOlfA through hOlfD and the TIGR/myocilin protein. hOlfA
corresponds to the rat neuronal AMZ protein. Phylogenetic analyses of 18 olfactomedin-related
sequences resolved four distinct subfamilies. Among the human proteins, hOlfA and hOlfC, both
expressed in brain, are most closely related. Northern blot analyses of 16 human tissues
demonstrated highly specific expression patterns: hOlfA is expressed in brain, hOlfB in pancreas
and prostate, hOlfC in cerebellum, hOlfD in colon, small intestine and prostate and
TIGR/myocilin in heart and skeletal muscle. The link between TIGR/myocilin and ocular
hypertension and the expression of several of these proteins in mucus-lined tissues suggest that
they play an important role in regulating physical properties of the extracellular environment.
Future studies can now assess whether other members of this gene family, like TIGR/myocilin, are
also associated with human disease processes.
The determination of optimal experimental conditions in flow injection analysis asynchronous merging zone technique (FIA-AMZ) on the basis of a mathematical model is proposed. An improved commutator ...enabling reagent addition with minimal frontal dispersion is used for the simultaneous determination of two species,
Fe2+ and Fe3+ ions. The mathematical model used to simulate the detector response is based on a bell-shaped function. The model is well suited for the fitting of symmetrical as well as for very asymmetrical detector responses, reflecting different dispersion of the sample plugs. The influence of the frontal dispersion of the reagent, asymmetrically added to the sample plug, is studied using the proposed model. A measure for an optimal ratio between the sensitivity and repeatability is described on the basis of the parameters obtained from the simulations of the experimental curves obtained for different dispersions.
Prussiae Nova Tabula.Antraštė šiuolaikine rašyba
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Category of scale: Linear scale; Constant ratio linear horizontal scale: 1400000
Scale: ca 1:1400000.
REGNI POLONIAE et Ducatus LITHUANIAE VOLINIAE, PODOLIAE UCRANIAE PRUSSIAE, LIVONIAE et CURLANDIAE descriptio.Antraštė šiuolaikine rašyba
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Cosmographey, das ist Beschreibung aller Länder... / durch Sebastian Munster... verfasset
Kitoje žml. pusėje tekstas vok. ir lot. kalbomis: SARMATIA EVROPAEA.
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POLONIAE, LITUANIAEQ. DESCRIPTIO.Antraštė šiuolaikine rašyba
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Category of scale: Linear scale; Constant ratio linear horizontal scale: 2500000
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Original version note: Faksimilė iš: Orbis terrae compendiosa descriptio... Antverpiae: apud Joannem Baptistam Vrient, 1595.
Category of scale: Linear scale; Constant ratio linear horizontal scale: ...10000000
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DIVISION GÉNÉRALE DE L´EMPIRE DE RUSSIE COMPRISE EN EUROPE.
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CARTA MARINA NUOVA TAVOLA.Antraštė šiuolaikine rašyba
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La geografia di Claudio Tolomeo... / C. Ptolemaeus
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