Population Aging Cotlear, Daniel
2011, 2010, 12-13-2010, 20110101
eBook, Book
Open access
Latin America and the Caribbean will soon face the challenges of an aging population. This process, which took over a century in the rich world, will occur in two or three decades in the developing ...world; seven of the 25 countries that will age more rapidly are in LAC. Population aging will pose challenges and offer opportunities. This book explores three sets of issues. First is a group of issues related to the support of the aging and poverty in the life cycle. This covers questions of work and retirement, income and wealth, and living arrangements and intergenerational transfers. It also explores the relation between the life cycle and poverty. Second is the question of the health transition. How does the demographic transition impact the health status of the population and the demand for health care? And how advanced is the health transition in LAC? Third is an understanding of the fiscal pressures that are likely to accompany population aging and to disentangle the role of demography from the role of policy in that process. This book provides an introduction to the concepts and techniques at the intersection of demography and economics. It summarizes the policy debate about potential reforms needed to make population aging an opportunity for development.
Featured Cover Zane, Flaminia; Bouzid, Hayet; Sosa Marmol, Sofia ...
Aging cell,
11/2023, Volume:
22, Issue:
11
Journal Article
Peer reviewed
Open access
Cover legend: The cover image is based on the Research Article Smurfness‐based two‐phase model of ageing helps deconvolve the ageing transcriptional signature by Flaminia Zane et al., ...https://doi.org/10.1111/acel.13946 Image Credit: Michael Rera and Aurore Colibert
The development of frailty scores suitable for mice and which resemble those used in the clinical scenario is of great importance to understand human frailty. The aim of the study was to determine an ...individual frailty score for each mouse at different ages and analyze the association between the frailty score and its lifespan. For this purpose, the "Valencia Score" for frailty was used. Thus, a longitudinal study in mice was performed analyzing weight loss, running time and speed, grip strength and motor coordination at the late-adult, mature and old ages (40, 56 and 80 weeks old, respectively). These parameters are equivalent to unintentional weight loss, poor endurance, slowness, weakness, and low activity level, respectively, in humans. A cut-off point was used to identify frail mice for each criterion. All the measurements were also performed on chronologically adult prematurely aging mice. The results show that by using the "Valencia Score" for frailty a prematurely aged phenotype can be identified even during the adulthood of animals. This opens up the possibility of carrying out preventive long-term interventions. Moreover, the individual frailty score of a given mouse at the late-adult, mature and old ages is shown to be a relevant predictor of its lifespan.
For several decades, understanding ageing and the processes that limit lifespan have challenged biologists. Thirty years ago, the biology of ageing gained unprecedented scientific credibility through ...the identification of gene variants that extend the lifespan of multicellular model organisms. Here we summarize the milestones that mark this scientific triumph, discuss different ageing pathways and processes, and suggest that ageing research is entering a new era that has unique medical, commercial and societal implications. We argue that this era marks an inflection point, not only in ageing research but also for all biological research that affects the human healthspan.
Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly
. To define the contribution of immune system ageing to organism ageing, here we ...selectively deleted Ercc1, which encodes a crucial DNA repair protein
, in mouse haematopoietic cells to increase the burden of endogenous DNA damage and thereby senescence
in the immune system only. We show that Vav-iCre
;Ercc1
mice were healthy into adulthood, then displayed premature onset of immunosenescence characterized by attrition and senescence of specific immune cell populations and impaired immune function, similar to changes that occur during ageing in wild-type mice
. Notably, non-lymphoid organs also showed increased senescence and damage, which suggests that senescent, aged immune cells can promote systemic ageing. The transplantation of splenocytes from Vav-iCre
;Ercc1
or aged wild-type mice into young mice induced senescence in trans, whereas the transplantation of young immune cells attenuated senescence. The treatment of Vav-iCre
;Ercc1
mice with rapamycin reduced markers of senescence in immune cells and improved immune function
. These data demonstrate that an aged, senescent immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy ageing.
PDF
