Imitation is a normal activity for children, and it is a process of learning. However, some educators think that children who imitate are children who are poor at drawing pictures. I think that ...breaking down such an image of imitating children will lead to their further creative activities. This study analyzed children’s imitation behavior that occurred in everyday class in order to clarify the meaning of imitation as to how it happened, how it changed production, and how it led to learning. The study further attempted to consider how teachers should act on it. The results confirmed many cases in which children overcame difficulties by imitation when they could not progress any further in the production. 39 cases in which what children imitated was related to the evaluation viewpoints were extracted from the total 97 cases, and it was clarified that imitation that leads to “ideas are often that of words or images, and that imitation that leads to “skills” occurs when teachers give “instructions” or “examples.” It was clarified that out of teachers’ relationships with children, “presentation” and “agreement” prompt students to imitate one another.”
U obrazovnom sustavu Srbije kombinirana odjeljenja imaju
bitnu ulogu, pogotovo u primanom obrazovanju. Kako bi ispunili obrazovne zadaće u kombiniranim odjeljenjima učitelji moraju posjedovati ...primjereno znanje, ali i vještine, kreativnost i visok stupanj motiviranosti. Cilj istraživanja bio je analizirati stavove učitelja u Srbiji o radu u kombiniranim odjeljenjima. Primijenjene su deskriptivne i statističke metode, dok su podaci prikupljeni terenskim
istraživanjem, akcijskim istraživanjem i kombiniranim tehnikama. U
istraživanju su sudjelovali učitelji iz Vojvodine. Prema defi niranim zadacima dizajniran je i primjenjen upitnik za učitelje. Rezultati pokazuju visok stupanj motiviranosti učitelja za rad u kombiniranim odjeljenjima, ali i nizak stupanj primjerene pripreme. Profesionalna obuka trebala bi se poboljšati kako bi učiteljima omogućila uspješno ostvarivanje obrazovnih potreba.
Cardiovascular diseases are the leading causes of mortality. Sudden cardiac death is most commonly caused by ventricular fibrillation (VF). Atrial fibrillation (AF) is the most common sustained ...cardiac arrhythmia and a major cause of stroke and heart failure. Pharmacological management of VF and AF remains suboptimal due to limited efficacy of antiarrhythmic drugs and their ventricular proarrhythmic adverse effects. In this study, the antiarrhythmic and cardiac cellular electrophysiological effects of SZV-270, a novel compound, were investigated in rabbit and canine models. SZV-270 significantly reduced the incidence of VF in rabbits subjected to coronary artery occlusion/reperfusion and reduced the incidence of burst-induced AF in a tachypaced conscious canine model of AF. SZV-270 prolonged the frequency-corrected QT interval, lengthened action potential duration and effective refractory period in ventricular and atrial preparations, blocked I
Kr
in isolated cardiomyocytes (Class III effects), and reduced the maximum rate of depolarization (V
max
) at cycle lengths smaller than 1000 ms in ventricular preparations (Class I/B effect). Importantly, SZV-270 did not provoke Torsades de Pointes arrhythmia in an anesthetized rabbit proarrhythmia model characterized by impaired repolarization reserve. In conclusion, SZV-270 with its combined Class I/B and III effects can prevent reentry arrhythmias with reduced risk of provoking drug-induced Torsades de Pointes.
Cardiovascular diseases are the leading causes of mortality. Sudden cardiac death is most commonly caused by ventricular fibrillation (VF). Atrial fibrillation (AF) is the most common sustained ...cardiac arrhythmia and a major cause of stroke and heart failure. Pharmacological management of VF and AF remains suboptimal due to limited efficacy of antiarrhythmic drugs and their ventricular proarrhythmic adverse effects. In this study, the antiarrhythmic and cardiac cellular electrophysiological effects of SZV-270, a novel compound, were investigated in rabbit and canine models. SZV-270 significantly reduced the incidence of VF in rabbits subjected to coronary artery occlusion/reperfusion and reduced the incidence of burst-induced AF in a tachypaced conscious canine model of AF. SZV-270 prolonged the frequency-corrected QT interval, lengthened action potential duration and effective refractory period in ventricular and atrial preparations, blocked
in isolated cardiomyocytes (Class III effects), and reduced the maximum rate of depolarization (
) at cycle lengths smaller than 1000 ms in ventricular preparations (Class I/B effect). Importantly, SZV-270 did not provoke Torsades de Pointes arrhythmia in an anesthetized rabbit proarrhythmia model characterized by impaired repolarization reserve. In conclusion, SZV-270 with its combined Class I/B and III effects can prevent reentry arrhythmias with reduced risk of provoking drug-induced Torsades de Pointes.
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