Abstract Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in Caucasian populations, accounting for 20% of all cutaneous malignancies. A unique collaboration of ...multi-disciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization of Research and Treatment of Cancer (EORTC) was formed to make recommendations on cSCC diagnosis and management, based on a critical review of the literature, existing guidelines and the expert’s experience. The diagnosis of cSCC is primarily based on clinical features. A biopsy or excision and histologic confirmation should be performed in all clinically suspicious lesions in order to facilitate the prognostic classification and correct management of cSCC. The first line treatment of cutaneous SCC is complete surgical excision with histopathological control of excision margins. The EDF–EADO–EORTC consensus group recommends a standardised minimal margin of 5 mm even for low-risk tumours. For tumours, with histological thickness of >6 mm or in tumours with high risk pathological features, e.g. high histological grade, subcutaneous invasion, perineural invasion, recurrent tumours and/or tumours at high risk locations an extended margin of 10 mm is recommended. As lymph node involvement by cSCC increases the risk of recurrence and mortality, a lymph node ultrasound is highly recommended, particularly in tumours with high-risk characteristics. In the case of clinical suspicion or positive findings upon imaging, a histologic confirmation should be sought either by fine needle aspiration or by open lymph node biopsy. In large infiltrating tumours with signs of involvement of underlying structures, additional imaging tests, such as CT or MRI imaging may be required to accurately assess the extent of the tumour and the presence of metastatic spread. Current staging systems for cSCC are not optimal, as they have been developed for head and neck tumours and lack extensive validation or adequate prognostic discrimination in certain stages with heterogeneous outcome measures. Sentinel lymph node biopsy has been used in patients with cSCC, but there is no conclusive evidence of its prognostic or therapeutic value. In the case of lymph node involvement by cSCC, the preferred treatment is a regional lymph node dissection. Radiation therapy represents a fair alternative to surgery in the non-surgical treatment of small cSCCs in low risk areas. It generally should be discussed either as a primary treatment for inoperable cSCC or in the adjuvant setting. Stage IV cSCC can be responsive to various chemotherapeutic agents; however, there is no standard regimen. EGFR inhibitors such as cetuximab or erlotinib, should be discussed as second line treatments after mono- or polychemotherapy failure and disease progression or within the framework of clinical trials. There is no standardised follow-up schedule for patients with cSCC. A close follow-up plan is recommended based on risk assessment of locoregional recurrences, metastatic spread or development of new lesions.
More than 100 countries pledged to reduce agricultural greenhouse gas (GHG) emissions in the 2015 Paris Agreement of the United Nations Framework Convention on Climate Change. Yet technical ...information about how much mitigation is needed in the sector vs. how much is feasible remains poor. We identify a preliminary global target for reducing emissions from agriculture of ~1 GtCO2e yr−1 by 2030 to limit warming in 2100 to 2 °C above pre‐industrial levels. Yet plausible agricultural development pathways with mitigation cobenefits deliver only 21–40% of needed mitigation. The target indicates that more transformative technical and policy options will be needed, such as methane inhibitors and finance for new practices. A more comprehensive target for the 2 °C limit should be developed to include soil carbon and agriculture‐related mitigation options. Excluding agricultural emissions from mitigation targets and plans will increase the cost of mitigation in other sectors or reduce the feasibility of meeting the 2 °C limit.
Mercury is a potent neurotoxin that poses health risks to the global population. Anthropogenic mercury emissions to the atmosphere are projected to decrease in the future due to enhanced policy ...efforts such as the Minamata Convention, a legally-binding international treaty entered into force in 2017. Here, we report the development of a comprehensive climate-atmosphere-land-ocean-ecosystem and exposure-risk model framework for mercury and its application to project the health effects of future atmospheric emissions. Our results show that the accumulated health effects associated with mercury exposure during 2010-2050 are $19 (95% confidence interval: 4.7-54) trillion (2020 USD) realized to 2050 (3% discount rate) for the current policy scenario. Our results suggest a substantial increase in global human health cost if emission reduction actions are delayed. This comprehensive modeling approach provides a much-needed tool to help parties to evaluate the effectiveness of Hg emission controls as required by the Minamata Convention.
We report the updated classification of primary immunodeficiencies compiled by the Primary Immunodeficiency Expert Committee (PID EC) of the International Union of Immunological Societies (IUIS). In ...the two years since the previous version, 34 new gene defects are reported in this updated version. For each disorder, the key clinical and laboratory features are provided. In this new version we continue to see the increasing overlap between immunodeficiency, as manifested by infection and/or malignancy, and immune dysregulation, as manifested by auto-inflammation, auto-immunity, and/or allergy. There is also an increased number of genetic defects that lead to susceptibility to specific organisms which reflects the finely tuned nature of immune defense systems. This classification is the most up to date catalogue of all known and published primary immunodeficiencies and acts as a current reference of the knowledge of these conditions and is an important aid for the genetic and molecular diagnosis of patients with these rare diseases.
Preface: CIB World Building Congress 2022 Behm, Michael; Aranda-Mena, Guillermo; Wakefield, Ron ...
IOP Conference Series: Earth and Environmental Science,
11/2022, Volume:
1101, Issue:
1
Journal Article
Peer reviewed
Open access
1. World Building Congress 2022 Overview
The International Council for Research and Innovation in Building and Construction (CIB) World Building Congress (WBC) 2022 ‘Building Our Future: Informing ...Practice to Enhance the Lives of Current and Future Generations’ was held from 27 to 30 June 2022 at RMIT University in Melbourne, Australia and online. The WBC is a triennial event bringing together the global scientific community to share ideas about cutting-edge research affecting the built environment. The inaugural WBC was held in Rotterdam, The Netherlands in 1959. CIB (Conseil International du Bâtiment) is a member-driven platform to provide a network for international collaboration in building and construction research and innovation.
List of WBC 2022 Scientific Committee, W078 Scientific Committee are available in this pdf.
Notwithstanding great progress in scientific and economic understanding of climate change, it has proven difficult to forge international agreements because of free-riding, as seen in the defunct ...Kyoto Protocol. This study examines the club as a model for international climate policy. Based on economic theory and empirical modeling, it finds that without sanctions against non-participants there are no stable coalitions other than those with minimal abatement. By contrast, a regime with small trade penalties on non-participants, a Climate Club, can induce a large stable coalition with high levels of abatement.
An overview of international human rights and social justice, this introductory text focuses on current global problems of pressing concern for social workers. It addresses topics such as healthcare, ...violence against women, war and conflict, forced labor and child soldiers, in a manner which encourages students to think critically about such problems, research the issues, and get involved with organizations that are working on them. The content contains narratives of individuals suffering from these social problems, as well as suggestions for what students can do to create change: both now and what they will be able to do as professionals. The author analyzes problems in their cultural contexts in order to help the reader understand how they developed, why they persist, and what the local and international responses — both governmental and non-governmental — have been.
Why do aid agencies from wealthy donor countries with diverse domestic political and economic contexts arrive at very similar positions on a wide array of aid policies and priorities? This book ...suggests that this homogenization of policy represents the effects of common processes of globalization manifest in the aid sector. Drawing on both quantitative and qualitative analysis of policy adoption, the book argues that we need to examine macro-level globalizing influences at the same time as understanding the micro-level social processes at work within aid agencies, in order to adequately explain the so-called ‘emerging global consensus’ that constitutes the globalization of aid.
The book explores how global influences on aid agencies in Canada, Sweden, and the United States are mediated through micro-level processes. Using a mixed-methods approach, the book combines cross-national statistical analysis at the global level with two comparative case studies which look at the adoption of common policy priorities in the fields of gender and security. The Globalization of Foreign Aid will be useful to researchers of foreign aid, development, international relations and globalization, as well as to the aid policy community.
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