Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority of natural products remain ...undiscovered, and computational methods to connect biosynthetic gene clusters to their corresponding natural products therefore have the potential to revitalize natural product discovery. Previously, we described PRediction Informatics for Secondary Metabolomes (PRISM), a combinatorial approach to chemical structure prediction for genetically encoded nonribosomal peptides and type I and II polyketides. Here, we present a ground-up rewrite of the PRISM structure prediction algorithm to derive prediction of natural products arising from non-modular biosynthetic paradigms. Within this new version, PRISM 3, natural product scaffolds are modeled as chemical graphs, permitting structure prediction for aminocoumarins, antimetabolites, bisindoles and phosphonate natural products, and building upon the addition of ribosomally synthesized and post-translationally modified peptides. Further, with the addition of cluster detection for 11 new cluster types, PRISM 3 expands to detect 22 distinct natural product cluster types. Other major modifications to PRISM include improved sequence input and ORF detection, user-friendliness and output. Distribution of PRISM 3 over a 300-core server grid improves the speed and capacity of the web application. PRISM 3 is available at http://magarveylab.ca/prism/.
## In Detail Ensuring your website is up, fast, and secure is a difficult yet crucial task. Learning how to protect and safeguard your web presence from malicious attackers whilst also making sure ...that it is optimized is important for any website administrator. CloudFlare helps you augment your website with additional security, as well as provide the extra bit of speed that will set you apart from the competition. "Instant CloudFlare Starter" will show you how to leverage the power of the cloud to ensure that your website is running at its very best. It will also tell you exactly what CloudFlare is doing when you enable various features, and guide you through the entire setup and configuration process. After learning about what CloudFlare actually is, you'll be shown how to fully optimize and secure your own website - using the latest that CloudFlare has to offer. As well as ensuring that your own site is protected with CloudFlare, you'll learn exactly how it actually secures your website from malicious attackers. This is in addition to making sure that you can send and receive emails effectively from your own domain, as well as learning how CloudFlare can enable your site's static assets to load quickly, with little effort on your part. You'll be guided through the whole optimization process - with additional tips and guidance that help you avoid common mistakes and pitfalls, alongside coverage of optional modules that can additionally improve the speed of your website, add analytics, or even entirely new functionality. With detailed explanations of things to look out for and how CloudFlare can solve your problems on your website, "CloudFlare Starter" will ultimately show you how to optimize and secure your website effectively with minimum hassle. ## Approach Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Written as a practical guide, CloudFlare Starter will show you all you need to know in order to effectively improve your online presence in a multitude of different ways. ## Who this book is for "Instant CloudFlare Starter" is a practical yet accessible guide for website owners looking to optimize their site for optimum security and maximum performance.
The web service computing paradigm has introduced great benefits to the growth of e-markets, both under the customer to business and the business to business models. The value capabilities allowed by ...the conception of web services, such as interoperability, efficiency, just-in-time integration, etc., have made them the most common way of doing business online. With the maturation of the web services underlying functional properties and facilitating standards, and with the proliferation of the amounts of data they use and they generate, researchers and practitioners have been dedicating considerable efforts to the related emerging privacy concerns. The literature contains number of research works on these privacy concerns, each addressing them from a different focal point. We have explored the available literature on web services privacy during transactions, to present, in this paper, a thorough survey of the most relevant published proposals. We identified 20 works that address privacy related problems in web services consumption. We categorize them based on the approach they take and we compare them based on a proposed evaluation framework, derived from the adopted techniques and addressed requirements.
Automated composition of Web Services can be achieved by using AI planning techniques. Hierarchical Task Network (HTN) planning is especially well-suited for this task. In this paper, we describe how ...HTN planning system SHOP2 can be used with OWL-S Web Service descriptions. We provide a sound and complete algorithm to translate OWL-S service descriptions to a SHOP2 domain. We prove the correctness of the algorithm by showing the correspondence to the situation calculus semantics of OWL-S. We implemented a system that plans over sets of OWL-S descriptions using SHOP2 and then executes the resulting plans over the Web. The system is also capable of executing information-providing Web Services during the planning process. We discuss the challenges and difficulties of using planning in the information-rich and human-oriented context of Web Services.
Purpose
This paper aims to explore recent trends of how Web 2.0 applications were used in 75 academic libraries in Asia through their library websites.
Design/methodology/approach
The Times Higher ...Education Asia University Rankings 2016 was considered for this study and out of 200 top universities ranked, 75 universities were selected for data collection. Using a multi-method approach, this study evaluated key design elements, library service platforms and website content of each academic library website, examining their site features, Web 2.0 types and applications. The criteria for selecting the websites were first the website was in English and second had Web 2.0 applications integrated into the main website. For the ranking of websites, a library web service index was developed, benchmarking from these groups – resource discovery tools, Web 2.0 applications, e-resources, mobile applications, library guides, digital reference services and digital inclusion – as indicators.
Findings
The authors found that over two-thirds of Asian university libraries have deployed one or more Web 2.0 applications, though their popularity and implementation vary greatly. Most widely used Web 2.0 applications are Facebook (61.3 per cent), RSS (53.3 per cent), Twitter (46.7 per cent) and YouTube (37.3 per cent). Instant messaging (5.3 per cent) and podcasting (4 per cent) were least applied. With an average of 44 per cent, the diffusion rate of Web information is moderately high among the majority of the Asian university libraries.
Originality/value
Many studies explored Web 2.0 applications from developed countries. However, this study attempts evaluating the use of Web 2.0 applications through content, sites and features of academic libraries in Asia, from developing countries perspective.
Cold-formed steel (CFS) channels with edge-stiffened web holes are widely used as flooring joists and bearers in industrial buildings and their flanges are fastened in most cases. This prevents the ...rotation of flanges and increases their web crippling capacity. In the literature, no information is available on the web crippling capacity of such fastened CFS channels with edge-stiffened web holes. This study presents the results of 36 new web crippling tests which were conducted on CFS channels with edge-stiffened web holes under fastened support subjected to two-flange loading. For comparison, specimens with no hole and un-stiffened web holes were also tested. Finite element (FE) models were then developed and validated against the experimental results. Using the validated FE models, an extensive parametric study involving 912 FE models was conducted. In the parametric study, web thickness, size of the web holes, length of bearing plate and length of edge-stiffener were varied. Test results indicated that the specimens with fastened flanges have higher ultimate capacity than those with unfastened flanges. For the case of fastened flanges, the web crippling capacity increased by 71% and 33% for the end-two-flange (ETF) and interior-two-flange (ITF) loading, respectively. Finally, the test results were compared with the design strengths predicted by the proposed equations of Uzzaman et al. (2020) for channels with web holes, and against the design equations of current design standards (American Iron and Steel Institute (AISI) (2016), Australian and New Zealand Standards (AS/NZS) (2018), and European Standard (EC3) (2006)) for plain channels. Upon comparison, it was found that the web crippling capacity reduction factor proposed by Uzzaman’s equations (2020) gave close predictions to the test results for CFS channels with edge-stiffened web holes.
•36 new web crippling test results on fastened CFS channels were reported.•FE models have been developed and verified against the test results.•A parametric study comprising 912 FE models was conducted.•The stiffened holes can improve the web crippling capacity of such sections.•Specimen with fastened flange has higher strength than those with unfastened flange.
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