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Pregled literature o antioksidativnih učinkih koencima Q10 pri srčno-žilnih bolnikih = Literature review of coenzyme Q10 antioxidative effects in cardiovascular patients : enoviti magistrski študijski program FarmacijaJeram, KatarinaKoencim Q10 je nizkomolekularni antioksidant endogenega izvora. Njegove glavne funkcije temeljijo na sposobnosti sprejemanja in oddajanja elektronov: sodeluje pri prenosu elektronov med kompleksi v ... mitohondrijski dihalni verigi in v procesu oksidativne fosforilacije, zavira lipidno peroksidacijo in je sposoben regenerirati α-tokoferol. Zato ima koencim Q10 pomembno vlogo tudi v procesu ateroskleroze, ki je vzrok za večino srčno-žilnih bolezni. Namen naloge je bilo izvesti sistematičen pregled vse dostopne literature, ki je obravnavala antioksidativne učinke koencima Q10 pri srčno-žilnih bolnikih oz. osebah z visokim tveganjem za srčno-žilna obolenja. Preučevani parametri so bili: superoksid dismutaza, malondialdehid, interlevkin 6, visoko občutljiv C-reaktivni protein, holesterol v lipoproteinih nizke gostote, vrednost od pretoka odvisne dilatacije. Sestavili smo ustrezen iskalni profil in literaturo iskali v podatkovnih bazah PubMed, Web of Science in Google Učenjak, pri čemer smo sledili načelom PRISMA. Od skupno 1738 zadetkov smo v literaturni pregled vključili 21 raziskav, ki so ustrezale vključitvenim kriterijem. Ocenili smo kakovost izbranih raziskav in za vsako izpisali osnovne podatke ter nato med seboj primerjali raziskave, ki so obravnavale paciente s primerljivim srčno-žilnim stanjem. Raziskave so pokazale na nekonsistentne povezave med uživanjem koencima Q10 in povišanjem aktivnosti SOD ter znižanjem koncentracije MDA. Glede protivnetnega učinka koencima Q10 so bili rezultati nasprotujoči. Raziskave niso pokazale konsistentnega pozitivnega učinka uživanja koencima Q10 na zniževanje koncentracije LDL-hol, pokazale pa so konsistenten pozitiven učinek na vrednost FMD pri osebah z visokim tveganjem za srčno-žilna obolenja. Na osnovi našega sistematičnega pregleda literature lahko zaključimo, da so raziskave pokazale na nekonsistentne antioksidativne učinke uživanja koencima Q10 in bi za zanesljive ugotovitve potrebovali več kakovostnih raziskav.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [K. Jeram], 2022Language - slovenianCOBISS.SI-ID - 135190019
Author
Jeram, Katarina
Other authors
Mravljak, Janez, 1978-
Topics
Antioksidanti |
Srčne napake |
Referenčna literatura |
koencim Q10 |
srčno-žilne bolezni |
literaturni pregled |
analiza raziskav
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Faculty of Pharmacy, Lj. | Knjižnica emšf 577 JERAM KATARINA Pregled 1205 IN: 0017547 |
available - reading room |
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jeram, Katarina | ![]() |
Mravljak, Janez, 1978- | 23419 |
Source: Personal bibliographies
and: SICRIS
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