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Development of nanofibers with embedded liposomes containing an immunomodulatory drug using green electrospinning [Elektronski vir]Casula, Luca ...Conventional treatments for chronic wounds are often ineffective, thus new therapeutic approaches are needed, such as the delivery of immunomodulatory drugs that can reduce inflammation, restore ... immune cell function, and facilitate tissue regeneration. A potential drug for such an approach is simvastatin, which has major drawbacks including poor solubility and chemical instability. With the aim of developing a dressing for wound healing, simvastatin and an antioxidant were incorporated into alginate/poly(ethylene oxide) nanofibers by green electrospinning without the use of organic solvents, thanks to their prior encapsulation into liposomes. The composite liposome–nanofiber formulations exhibited fibrillar morphology (160–312 nm) and unprecedentedly high phospholipid and drug content (76%). Transmission electron microscopy revealed dried liposomes as bright ellipsoidal spots homogeneously distributed over the nanofibers. After nanofiber hydration, the liposomes reconstituted in two size populations (~140 and ~435 nm), as revealed by cutting-edge MADLS® analysis. Lastly, in vitro assays demonstrated that composite liposome–nanofiber formulations are superior to liposomal formulations due to a better safety profile in keratinocytes and peripheral blood mononuclear cells. Furthermore, both formulations exhibited similarly advantageous immunomodulatory effects, measured as decreased inflammation in vitro. A synergistic combination of the two nanodelivery systems shows promise for the development of efficient dressings for chronic wound treatment.Source: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 15, iss. 4, art. 1245, 2023, 19 str.)Type of material - e-article ; adult, seriousPublish date - 2023Language - englishCOBISS.SI-ID - 149379587
Author
Casula, Luca |
Zidar, Anže |
Kristl, Julijana |
Jeras, Matjaž |
Kralj, Slavko, 1983- |
Fadda, Anna Maria |
Zupančič, Špela, farmacevtka
Topics
Imunomodulacija |
Nanovlakna |
simvastatin |
liposomi v nanovlaknih |
zeleno elektropredenje |
imunomodulacija |
obloga za rane |
alginat |
transmisijska elektronska mikroskopija |
večkotno dinamično sipanje svetlobe |
varnost in vitro |
simvastatin |
liposomes in nanofibers |
green electrospinning |
immunomodulation |
wound dressing |
alginate |
TEM |
MADLS analysis |
in vitro safety
Author | Casula, Luca ... |
Title | Development of nanofibers with embedded liposomes containing an immunomodulatory drug using green electrospinning [Elektronski vir] |
Publication date | 2023-04-14 |
COBISS.SI-ID | 149379587 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
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Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Sodobni magnetni in večnamenski materiali | P2-0089-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Nanozdravila z antibiotiki in probiotiki za lokalno zdravljenje parodontalne bolezni | J1-9194-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Izkoriščanje magneto-mehanskega učinka pri zdravljenju nevrodegenerativnih bolezni | J2-3043-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Nanovlakna za sočasno dostavo koktajlov izbrane mikrobiote in protimikrobnih učinkovin za lokalno zdravljenje vaginalnih infekcij | J7-4418 | ||
UniCA- Progetti biennali d’Ateneo | CUPF73C22001170007 |
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https://www.mdpi.com/1999-4923/15/4/1245 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=145335 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Casula, Luca | |
Zidar, Anže | 53870 |
Kristl, Julijana | 09032 |
Jeras, Matjaž | 01302 |
Kralj, Slavko, 1983- | 29529 |
Fadda, Anna Maria | |
Zupančič, Špela, farmacevtka | 36439 |
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