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Endoglin (CD105) silencing mediated by shRNA under the control of Endothelin-1 promoter for targeted gene therapy of Melanoma [Elektronski vir]Tešić, Nataša ...Endoglin (CD105), a transforming growth factor (TGF)-% coreceptor, and endothelin-1, a vasoconstrictor peptide, are both overexpressed in tumor endothelial and melanoma cells. Their targeting is ... therefore a promising therapeutic approach for melanoma tumors. The aim of our study was to construct a eukaryotic expression plasmid encoding the shRNA molecules against CD105 under the control of endothelin-1 promoter and to evaluate its therapeutic potential both in vitro in murine B16F10-luc melanoma and SVEC4-10 endothelial cells and in vivo in mice bearing highly metastatic B16F10-luc tumors. Plasmid encoding shRNA against CD105 under the control of the constitutive U6 promoter was used as a control. We demonstrated the antiproliferative and antiangiogenic effects of both plasmids in SVEC4-10 cells, as well as a moderate antitumor and pronounced antimetastatic effect in B16F10-luc tumors in vivo. Our results provide evidence that targeting melanoma with shRNA molecules against CD105 under the control of endothelin-1 promoter is a feasible and effective treatment, especially for the reduction of metastatic spread.Source: Molecular therapy. Nucleic acids [Elektronski vir]. - ISSN 2162-2531 (No. 4, May 2015)Type of material - e-articlePublish date - 2015Language - englishCOBISS.SI-ID - 1537399748
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Tešić, Nataša | 34477 |
Kamenšek, Urška | 28387 |
Serša, Gregor | 08800 |
Kranjc, Simona, 1972- | 19058 |
Štimac, Monika | 35355 |
Lampreht Tratar, Urša | 36367 |
Préat, Véronique | ![]() |
Vandermeulen, Gaëlle | ![]() |
Butinar, Miha | 33315 |
Turk, Boris, 1964- | 07561 |
Čemažar, Maja | 14575 |
Source: Personal bibliographies
and: SICRIS
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