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High reactive oxygen species levels are detected at the end of the chronological life span of translocant yeast cellsSims, Jason ...Chromosome translocation is a major genomic event for a cell, affecting almost every of its life aspects ranging from metabolism, organelle maintenance and homeostasis to gene maintenance and ... expression. By using the bridge-induced translocation system, we defined the effects of induced chromosome translocation on the chronological life span (CLS) of yeast with particular interest to the oxidative stress condition. The results demonstrate that every translocant strain has a different CLS, but all have a high increase in reactive oxygen species and in lipid peroxides levels at the end of the life span. This could be due to the very unique and strong deregulation of the oxidative stress network. Furthermore, the loss of the translocated chromosome occurs at the end of the life span and is locus dependent. Additionally, the RDH54 gene may play a role in the correct segregation of the translocant chromosome, since in its absence there is an increase in loss of the bridge-induced translocated chromosome.Source: Molecular genetics and genomics : MGG. - ISSN 1617-4615 (Vol. 291, iss. 1, Febr. 2016, str. 423-435)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 1538198212
Author
Sims, Jason |
Bruschi, Carlo V. |
Bertin, Chloé |
West, Nicole |
Breitenbach, Michael |
Schroeder, Sabrina |
Eisenberg, Tobias |
Rinnerthaler, Mark |
Raspor, Peter |
Tosato, Valentina
Topics
ageing |
chromosomal translocation |
lifespan |
yeast |
oxidative stress |
staranje |
kromosomske translokacije |
kvasovke |
oksidativni stres
source: Molecular genetics and genomics : MGG. - ISSN 1617-4615 (Vol. 291, iss. 1, Febr. 2016, str. 423-435)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sims, Jason | |
Bruschi, Carlo V. | |
Bertin, Chloé | |
West, Nicole | |
Breitenbach, Michael | |
Schroeder, Sabrina | |
Eisenberg, Tobias | |
Rinnerthaler, Mark | |
Raspor, Peter | 04001 |
Tosato, Valentina |
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