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Zaviralci poli(adenozin difosfat-riboza) polimeraze pri zdravljenju raka = Poly(adenosine diphosphate.ribose) polymeraseinhibitors in cancer therapyKenig, SašaOlaparib, zaviralec poli (ADP-riboza) polimeraze (PARP) je prvo protutumorsko zdravilo, ki deluje po principu t.i. sintezne smrtnosti, odobreno za uporabo v kliniki, in sicer za zdravljenje raka ... jajčnikov za bolnice z mutacijo genov BRCA1 ali BRCA2, ki sta pomembna pri popravljanju poškodb DNA s homologno rekombinacijo. Leta 2016 so odobrili še en zaviralec PARP -rukaparib, v različnih fazah kliničnih raziskav pa jih je še več. Mutacije BRCA so značilne tudi za druge vrste raka, poleg tega pa obstaja še mnogo mutacij ali epigenetskih sprememb, ki imajo za celico podobne posledice - za vse te bi zaviralci PARP bili lahko uporabni. So torej obetavni za široko skupino onkoloških bolnikov, vendar pa je za načrtovanje zdravljenja potrebno tako natančno poznavanje mehanizma delovanja zaviralcev, skupaj z možnimi načini razvoja odpornosti, kot tudi poznavanje genetskega ozadja bolnika. V peiapwvku predstavljamo kratek pregled novih spoznanj o tej skupini zdravil in njihovi uporabi.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn.68, št. 3, 2017, str. 203-209)Type of material - article, component partPublish date - 2017Language - slovenianCOBISS.SI-ID - 1539529668
Author
Kenig, Saša
Topics
homologna rekombinacija |
olaparib |
rak |
sintezna smrtnost |
zaviralci PARP
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn.68, št. 3, 2017, str. 203-209)
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Kenig, Saša | 25525 |
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