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Yang, Ming; Fan, Dong-Mei; Gao, Ying-Dai; Zhou, Yuan; Ji, Qing; Shao, Xiao-Feng; Wang, Jin-Hong; Xu, Yuan-Fu; Xiong, Dong-Sheng; Yang, Chun-Zheng
Zhōnghuá xuèyèxué zázhì 30, Issue: 12Journal Article
To investigate the role of Ara-C in regulating anti-CD3/anti-Pgp mediating T-lymphocytes activities against multi-drug resistant leukemia cells. The diabody of anti-CD3/anti-Pgp was purified by E-tag affinity chromatography. K562 and K562/A02 cells were treated with Ara-C. The expressions of B7-1 and B7-2 on K562 and K562/AO2 cells were detected by FACS. The cytotoxicity of T-lymphocytes combined with anti-CD3/anU-Pgp plus Ara-C was analyzed by CytoTox 96 nonradioactive method. The expressions of B7-1 and B7-2 on K562 and K562/A02 cells treated by Ara-C was significantly higher than those untreated. The effect/target ratio was from 0.39:1 to 25:1, and the killing rate of activated T cells to anti-drug-resistant leukemia cells was from (16.44 +/- 1.20)% to (60.49 +/- 2.90)%. The killing rates were increased gradually, with both the effect/target ratio and the antibody concentration increasing (P < 0.05). Ara-C may be an important adjuvant for improving anti-CD3/anti-Pgp mediating T-lymphocytes activities again
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