E-resources
-
Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responsesKanekiyo, Masaru; Joyce, M Gordon; Gillespie, Rebecca A; Gallagher, John R; Andrews, Sarah F; Yassine, Hadi M; Wheatley, Adam K; Fisher, Brian E; Ambrozak, David R; Creanga, Adrian; Leung, Kwanyee; Yang, Eun Sung; Boyoglu-Barnum, Seyhan; Georgiev, Ivelin S; Tsybovsky, Yaroslav; Prabhakaran, Madhu S; Andersen, Hanne; Kong, Wing-Pui; Baxa, Ulrich; Zephir, Kathryn L; Ledgerwood, Julie E; Koup, Richard A; Kwong, Peter D; Harris, Audray K; McDermott, Adrian B; Mascola, John R; Graham, Barney S
Nature immunology, 03/2019, Volume: 20, Issue: 3Journal Article
The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide broader protection against influenza. Here we designed a vaccine using the hypervariable receptor-binding domain (RBD) of viral hemagglutinin displayed on a nanoparticle (np) able to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years. Co-display of RBDs from multiple strains across time, so that the adjacent RBDs are heterotypic, provides an avidity advantage to cross-reactive B cells. Immunization with the mosaic RBD-np elicited broader antibody responses than those induced by an admixture of nanoparticles encompassing the same set of RBDs as separate homotypic arrays. Furthermore, we identified a broadly neutralizing monoclonal antibody in a mouse immunized with mosaic RBD-np. The mosaic antigen array signifies a unique approach that subverts monotypic immunodominance and allows otherwise subdominant cross-reactive B cell responses to emerge.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.