To evaluate the adaptation of different lithium disilicate glass-ceramic crown and whether different fabrication processes affect the adaptation of crowns. Thirty epoxy dies crowns were divided into 3 groups. They were cemented to domestic lithium disilicate glass-ceramic crowns in Group A, to IPS e.max CAD crowns in Group B and to IPS e.max Press crowns in Group C respectively. All crowns were cut by cutting machine. A confocal laser scanning microscope was used to measure the gap between crown tissue surface and die. There were significant differences in the three groups of measurement points(P<0.05). Within the groups, specimens in group A showed in the lowest marginal fit(46.8±9.1 μm). Those in group B showed the lowest shoulder suitability(59.3±7.9 μm), axial plane(50.5±3.6 μm) and occlusal surface(87.6±11.6 μm. Those in group C demonstrated the lowest axial plane angle(84.4±10.1) μm. In addition to the axial plane angle, the CAD/CAM system exhibited good accuracy of fit. The three groups of li