Familial motor neuron disease with Lewy body-like inclusions in the substantia nigra, the subthalamic nucleus, and the globus pallidus

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Familial motor neuron disease with Lewy body-like inclusions in the substantia nigra, the subthalamic nucleus, and the globus pallidus

Tranchant, C; Dugay, M H; Mohr, M; Wasser, P; Warter, J M

Journal of the neurological sciences, 03/1992, Volume: 108, Issue: 1

Journal Article

In a familial case of motor neuron disease (MND), 2 unusual features were noted in the necropsy. The first was a pallidoluysonigral degeneration, observed in only 4 other cases of MND and which was here asymptomatic. The second was the presence in degenerated spinal cord anterior horns and in degenerated basal ganglia of neuronal Lewy body-like inclusions stained by antibodies against ubiquitin.

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Tranchant, C | Dugay, M H | Mohr, M | Wasser, P | Warter, J M

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