Uranium isotope compositions (δ238) and Th/U in carbonates are being explored as paleoredox proxies to study global oceanic anoxia. However, the impact of changes to local depositional environments that might cause a decline in δ238U and an increase in Th/U has not been thoroughly investigated. Here we report a decline in δ238U (from +0.1 to -0.3‰) and an increase in Th/U from shallow-marine carbonates during the Paleocene-Eocene thermal maximum at Tingri (south Tibet). Changes of δ238U and Th/U are not fully coupled. The decline in δ238U coincided with a local sea-level fall, whereas the increase in Th/U occurred mainly during a sea-level rise. The decline in δ238U likely results from changes in redox conditions of pore waters and in primary carbonate mineralogy. The increase in Th/U is ascribed to reduced authigenic U(IV) accumulation. Here our results suggest that changes in local depositional environments can cause behavior of δ238U and Th/U resembling that induced by expanded global oceanic anoxia. This finding calls for caution to consider local factors before applying δ238U and Th/U as global paleoredox proxies.