Patofiziologija osteoporoze

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Patofiziologija osteoporoze

Kovačević, Ivana; Kardum, Željka; Prus, Višnja; Milas-Ahić, Jasminka

Reumatizam, 10/2014, Volume: 61, Issue: 2

Journal Article

Ravnoteža razgradnje i stvaranja kosti važna je za normalan proces pregradnje i održavanja koštane mase. Genetski, hormonski, imunološki i drugi čimbenici utječu na pregradnju kosti tijekom cijelog života. Poremećaj koštane pregradnje ključni je patofiziološki mehanizam nastanka osteoporoze i predstavlja složen proces u kojem sudjeluju koštane stanice, citokini i njihovi receptori. Danas je već poznata važna uloga RANK/RANKL/OPG sustava u patofiziologiji osteoporoze, ali se i dalje istražuju važni unutarstanični signalni putovi u nastanku osteoporoze i drugih metaboličkih bolesti kosti.

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Kovačević, Ivana | Kardum, Željka | Prus, Višnja | Milas-Ahić, Jasminka

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