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刘茜辉; 聂鑫; 贺勇; 银梦婷; 李贵星
四川大学学报(医学版), 03/2023, Volume: 54, Issue: 2Journal Article
目的 分析基础血清降钙素值(bCtn)在有甲状腺结节的高降钙素血症人群中对甲状腺髓样癌(MTC)的辅助诊断效能,以及术前血清bCtn、癌胚抗原(CEA)水平与MTC肿瘤分期的关系.方法 系统回顾四川大学华西医院2011-2020年收治的58名MTC和2016-2020年收治的84名非MTC患者的临床、病理、影像和检验资料,建立ROC曲线计算bCtn和CEA对MTC的诊断效能,比较不同肿瘤原发灶的情况和区域淋巴结受累情况的MTC患者术前bCtn、CEA水平差异.结果 bCtn从有甲状腺结节的高降钙素血症人群中诊断MTC的最佳截断值为31.54 pg/mL(男性)和22.60 pg/mL(女性).不同T分期的MTC患者术前bCtn水平差异有统计学意义(H=16.166,P=0.001)、术前CEA水平差异有统计学意义(H=9.447,P=0.024).不同N分期的MTC患者术前bCtn水平差异有统计学意义(H=7.919,P=0.019)、术前CEA水平差异有统计学意义(H=7.934,P=0.019).结论 血清bCtn在有甲状腺结节的高降钙素血症人群中诊断MTC的最佳截断值分别为31.54 pg/mL(男性)和22.60 pg/mL(女性).
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