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Min, Myintzu; Spelman, Tim; Lugaresi, Alessandra; Boz, Cavit; Spitaleri, Daniele LA; Pucci, Eugenio; Grand’Maison, Francois; Granella, Franco; Izquierdo, Guillermo; Butzkueven, Helmut; Sanchez-Menoyo, Jose Luis; Barnett, Michael; Girard, Marc; Trojano, Maria; Grammond, Pierre; Duquette, Pierre; Sola, Patrizia; Alroughani, Raed; Hupperts, Raymond; Vucic, Steve; Kalincik, Tomas; Van pesch, Vincent; Lechner-Scott, Jeannette
Multiple sclerosis, 10/2018, Volume: 24, Issue: 12Journal Article
Background: The current best practice suggests yearly magnetic resonance imaging (MRI) to monitor treatment response in multiple sclerosis (MS) patients. Objective: To evaluate the current practice of clinicians changing MS treatment based on subclinical new MRI lesions alone. Methods: Using MSBase, an international MS patient registry with MRI data, we analysed the probability of treatment change among patients with clinically silent new MRI lesions. Results: A total of 8311 MRI brain scans of 4232 patients were identified. Around 26.9% (336/1247) MRIs with one new T2 lesion were followed by disease-modifying therapy (DMT) change, increasing to 50.2% (129/257) with six new T2 lesions. DMT change was twice as likely with new T1 contrast enhancing compared to new T2 lesions odds ratio (OR): 2.43, 95% confidence interval (CI): 2.00–2.96 vs OR: 1.26 (95% CI: 1.22–1.29). DMT change with new MRI lesions occurred most frequently with ‘injectable’ DMTs. The probability of switching therapy was greater only after high-efficacy therapies became available in 2007 (after, OR: 1.43, 95% CI: 1.28–1.59 vs before, OR: 0.98, 95% CI: 0.520–1.88). Conclusion: MS clinicians rely increasingly on MRI alone in their treatment decisions, utilizing low thresholds (1 new T2 lesion) for optimizing MS therapy. This signals a shift towards no evidence of disease activity (NEDA)-3 since high-efficacy therapies became available.
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