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Vukusic, Sandra; Carra-Dalliere, Clarisse; Ciron, Jonathan; Maillart, Elisabeth; Michel, Laure; Leray, Emmanuelle; Guennoc, Anne-Marie; Bourre, Bertrand; Laplaud, David; Androdias, Géraldine; Bensa, Caroline; Bigaut, Kevin; Biotti, Damien; Branger, Pierre; Casez, Olivier; Cohen, Mikael; Daval, Elodie; Deschamps, Romain; Donze, Cécile; Dubessy, Anne-Laure; Dulau, Cécile; Durand-Dubief, Françoise; Guillaume, Maxime; Hebant, Benjamin; Kremer, Laurent; Kwiatkowski, Arnaud; Lannoy, Julien; Maarouf, Adil; Manchon, Eric; Mathey, Guillaume; Moisset, Xavier; Montcuquet, Alexis; Pique, Julie; Roux, Thomas; Marignier, Romain; Lebrun-Frenay, Christine
Multiple Sclerosis Journal, 01/2023, Volume: 29, Issue: 1Book Review, Journal Article
Objective: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). Background: MS typically affects young women in their childbearing years. Increasing evidence is available to inform questions raised by MS patients and health professionals about pregnancy issues. Methods: The French Group for Recommendations in Multiple Sclerosis (France4MS) reviewed PubMed and university databases (January 1975 through June 2021). The RAND/UCLA appropriateness method was developed to synthesise the scientific literature and expert opinions on healthcare topics; it was used to reach a formal agreement. Fifty-six MS experts worked on the full-text review and initial wording of recommendations. A group of 62 multidisciplinary healthcare specialists validated the final proposal of summarised evidence. Results: A strong agreement was reached for all 104 proposed recommendations. They cover diverse topics, such as pregnancy planning, follow-up during pregnancy and postpartum, delivery routes, locoregional analgesia or anaesthesia, prevention of postpartum relapses, breastfeeding, vaccinations, reproductive assistance, management of relapses and disease-modifying treatments. Conclusion: The 2022 recommendations of the French MS society should be helpful to harmonise counselling and treatment practice for pregnancy in persons with MS, allowing for better and individualised choices.
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