This article examines the course of US-Syrian relations since the Six Day War of 1967 and it demonstrates how they began deteriorating as the Cold War between the superpowers intensified. The author argues that the bilateral relations were adversely affected by several factors that marginalized Syria's image as a major player in the Middle East; Washington's tendency to pay excessive attention to Soviet designs in the Middle East; the rise of pan-Arabism, which portrayed Egypt as a major threat to US interests in the region; the persistence of the Arab-Israeli conflict, and above all, the small size of the Syrian state and the weakness of its economy which prevented the American policy makers from courting its leaders.