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Puente, Nagore; Cannich, Astrid; Piazza, Pier Vincenzo; Chaouloff, Francis; Grandes, Pedro; Marsicano, Giovanni; Cota, Daniela; Bellocchio, Luigi; Lafenêtre, Pauline
Nature neuroscience, 03/2010, Volume: 13, Issue: 3Journal Article
Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood. Using combined genetic and pharmacological approaches in mice, we found that ventral striatal CB1 receptors exerted a hypophagic action through inhibition of GABAergic transmission. Conversely, brain CB1 receptors modulating excitatory transmission mediated the well-known orexigenic effects of cannabinoids.
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