Deciphering cadherin-1 and cadherin-3 roles in pancreatic ductal adenocarcinoma aggressiveness

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Deciphering cadherin-1 and cadherin-3 roles in pancreatic ductal adenocarcinoma aggressiveness

Dobric, Aurélie; Siret, Carole; Terciolo, Chloé; Martirosyan, Anna; Germain, Sébastien; Bonier, Rénaté; Dirami, Thassadite; Dusetti, Nelson; Tomasini, Richard; Iovanna, Juan; Lombardo, Dominique; Rigot, Véronique; André, Frédéric

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... et al., 07/2017, Volume: 17, Issue: 3

Journal Article

Alterations in the expression of cell-cell adhesion molecules including cadherins have been reported in PDAC. Cadherins expression was immunohistochemically examined through human pancreatic cancer development and in PDX1-Cre, KrasG12D, Ink4a/Arfflox/flox mouse model developing PanIN lesions similar to human ones.To analyze a crosstalk between cadherins during PDAC progression, we selected BxPC-3...

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