E-resources
Peer reviewed
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Matos, Leandro Luongo de, MD, PhD; Manfro, Gabriel, MD, PhD; Santos, Ricardo Vieira dos, MD; Stabenow, Elaine, MD, PhD; Mello, Evandro Sobroza de, MD, PhD; Alves, Venâncio Avancini F., MD, PhD; Pinto, Fábio Roberto, MD, PhD; Kulcsar, Marco Aurélio Vamondes, MD, PhD; Brandão, Lenine Garcia, MD, PhD; Cernea, Cláudio Roberto, MD, PhD
Oral surgery, oral medicine, oral pathology and oral radiology, 08/2014, Volume: 118, Issue: 2Journal Article
Objective The aim of the study was to compare the thickness of primary tumors with the frequency of nodal metastases and survival in patients surgically treated for T1/T2N0 oral tongue squamous cell carcinoma. Study Design This is a retrospective longitudinal study with 74 patients. Results None of the patients with a tumor thickness (TT) ≤ 7 mm presented with nodal metastasis, whereas 25 of the patients with a TT > 7 mm (51.0%) developed metastases ( P < .0001). Multivariate analysis showed that TT > 7 mm was a risk factor for occult nodal metastasis (odds ratio = 8.7; P = .002) with 81.9% accuracy. TT > 10 mm was also a predictive factor of worse disease-free survival in these patients (hazard ratio = 12.2; P = .003). Conclusions Tumor thickness of greater than 7 mm is predictive of a higher incidence of lymph node metastasis, and a TT > 10 mm is predictive of worse disease-free survival in squamous cell carcinoma of the oral tongue.
