Purpose of Review This article aims to provide an update on literature data related to mandibular osteoradionecrosis (MORN) secondary to the irradiation of the head and neck region. Recent Findings Radiotherapy (RT) plays a crucial role in the contemporary management of head and neck cancer (HNC) patients and, despite intensity-modulated technique (IMRT), mandibular osteoradionecrosis (MORN) remains a significant RT-related complication. Based on its clinical manifestation, MORN can negatively affect patients’ quality of life. Preventive interventions should be prioritized. Summary This manuscript is expected to represent an opportunity to guide a clear proposal for clinical measures in the individual MORN situations.