Covid-19 is the first emergency that affected Italy in its regional institutional set-up. Through a qualitative-quantitative analysis of the regional resolutions in 2020, the article proposes a first analysis of the regional system. Drawing from their own resources, the regions have deployed 7.3 billion euros, of which two billion is intended for interventions to support families and 5.3 to support the production system. The regions that have implemented the most significant interventions per capita are the Autonomous Provinces, the regions with special statute and the large southern regions, the latter largely drawing on the resources of the structural funds. We observe an evolution in the allocation of resources from general and emergency aspects to specific characteristics of the regional production sectors. The regional system has shown a certain ability to mobilize financial resources and a significant degree of differentiation.