The COMPASS RICH-1 detector has undergone a major upgrade in 2016 with the installation of four novel MPGD-based photon detectors. They consist of large-size hybrid MPGDs with multi-layer architecture composed of two layers of Thick-GEMs and bulk resistive MicroMegas. A dedicated high voltage power supply system, based on CAEN HV modules, has been built and put in operation: it controls more than 100 HV channels. The system is required to protect the detectors against errors by the operator, monitor voltages and currents at a 1 Hz rate and automatically react to detector misbehavior. It includes also a HV compensation system against environmental pressure and temperature variation to grant the detector stability. The operation of a MPGD based single photon detector poses challenging requirements to the high voltage power supply systems employed in terms of high-resolution diagnostic features and dynamic voltage control. Systems satisfying all the needed features are not commercially available; for this reason a novel single channel high voltage system matching the MPGD needs has been designed and realized. In this article the COMPASS RICH-1 MPGD HV system implementation is described as well as its performance in terms of stability of the novel MPGD-based photon detectors during the physics data taking at COMPASS. The design, implementation and performance of a novel HV power supply system based on DC to DC converters and controlled by a FPGA device is presented. The capabilities of the first prototype of the new single HV channel power supply are illustrated when operated with a MPGD based single photon detector during a test beam exercise. The preliminary result of the multi channel system are briefly discussed.