Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent condition with cardiovascular and neurocognitive consequences. The alteration is the collapse of the upper airways during sleep, with consequent hypoxemia and hypercapnia, requiring a respiratory effort to reverse it. This leads to awakening, with the muscle contractions opening the airway followed by a period of hyperventilation. Sleep returns collapsing of the airway and restarting the cycle. Surgical procedures aiming increasing the airspace have been used, and orthognathic surgery has been indicated in more severe cases. This study presents a report of an OSAHS treatment through maxillomandibular advancement surgery. A 47-year-old patient with apnea-hypopnea index of 53.3 was submitted to previous septoplasty and uvulopalatopharyngoplasty without satisfactory results. The final treatment was maxillomandibular advancement surgery with excellent outcome and life quality improvement.