Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) and WorldView-3 (WV-3) satellite remote sensing data were used for mapping lithological units and hydrothermal alteration zones associated with Pb-Zn mineralization in the Kerman-Kashmar Tectonic Zone (KKTZ), Iran. The visible near infrared (VNIR), shortwave infrared (SWIR) and thermal infrared (TIR) bands of ASTER were used to map iron oxide/hydroxides, Al-OH minerals, Fe,Mg-OH minerals, quartz and carbonate minerals. The VNIR bands of WV-3 were used to discriminate Fe 3+ and Fe 2+ absorption intensities. Selective Principal Component analysis (SPCA), Spectral Angle Mapper (SAM), Linear Spectral Unmixing (LSU) and Automatic Lineament Extraction techniques were implemented. Lithological units were discriminated based on Al/Fe-OH, Fe 2+ /Fe 3+ and Mg-Fe-OH/CO3 absorption properties. The spatial distribution of hematite, goethite, jarosite, gypsum, calcite, dolomite, kaolinite and muscovite were comprehensively detected. Some prospective zones were identified in the intersection of N-S, NW-SE and NE-SW trending fault systems, gossan, argillic/phyllic and dolomitic units.