E-resources
Peer reviewed
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Yang, Michael G.; Xiao, Zili; Shi, Qing; Cherney, Robert J.; Tebben, Andrew J.; De Lucca, George V.; Santella, Joseph B.; Mo, Ruowei; Cvijic, Mary Ellen; Zhao, Qihong; Barrish, Joel C.; Carter, Percy H.
Bioorganic & medicinal chemistry letters, 02/2012, Volume: 22, Issue: 3Journal Article
We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure–activity relationships of 4 are described, and are also reconciled with those from the related 2-phenylsulfonylmethyl series. We report the synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamides (4) as CCR2 inhibitors for the potential treatment of inflammatory diseases. Several of the compounds display nanomolar binding affinity for CCR2. The in vitro structure–activity relationships of 4 are described, and are also reconciled with those from the related 2-phenylsulfonylmethyl series.
