Rebound lymphocytosis in a patient with chronic lymphocytic leukemia after cessation of a CDK 4/6 inhibitor for concomitant breast cancer

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Rebound lymphocytosis in a patient with chronic lymphocytic leukemia after cessation of a CDK 4/6 inhibitor for concomitant breast cancer

Doucette, Kimberley; Lai, Catherine; Pohlmann, Paula R

The breast journal, October 2020, 2020-10-00, 20201001, Volume: 26, Issue: 10

Journal Article

Herein, we present the case of a female with co‐occurring chronic lymphocytic leukemia (CLL) and metastatic ER/PR‐positive breast cancer, who when taken off palbociclib for severe neutropenia and infectious complications, experienced rebound lymphocytosis. Though this was ultimately a benign clinical outcome, it exemplifies how CDK4/6 inhibitors induce a cell cycle arrest by decreasing the proliferation of hematopoietic stem cells (HSC), in this case CLL cells, with recovery of counts once drug is stopped.

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Doucette, Kimberley | Lai, Catherine | Pohlmann, Paula R

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