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Doucette, Kimberley; Lai, Catherine; Pohlmann, Paula R
The breast journal, October 2020, 2020-10-00, 20201001, Volume: 26, Issue: 10Journal Article
Herein, we present the case of a female with co‐occurring chronic lymphocytic leukemia (CLL) and metastatic ER/PR‐positive breast cancer, who when taken off palbociclib for severe neutropenia and infectious complications, experienced rebound lymphocytosis. Though this was ultimately a benign clinical outcome, it exemplifies how CDK4/6 inhibitors induce a cell cycle arrest by decreasing the proliferation of hematopoietic stem cells (HSC), in this case CLL cells, with recovery of counts once drug is stopped.
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